Depression increases risk of early death in older adults
February 6, 2019
Science Daily/American Geriatrics Society
A research team designed a study to investigate the role depression symptoms play in an increased risk of death over time. The team also examined the role heart disease and stroke play in the link between depression symptoms and increased risk of death.
As we age, we become more likely to experience symptoms of depression. Research shows that depression's symptoms can be linked to a higher risk for death. Yet often, older adults' symptoms of depression may be missed by healthcare professionals.
What's more, symptoms of depression have been linked to heart disease and stroke in middle-aged and older adults. Researchers suggest that the depression-heart disease link could play a role in the increased risk of death among older adults who have symptoms of depression. There's also a known link between depression and deaths from cancer and falls in older adults. These connections might contribute to an increased risk of death for older adults, researchers suggest.
Since depression symptoms change over time, it's possible that studying those symptoms during an older adult's doctor visits could provide more information. To learn more, a research team designed a study to investigate the role depression symptoms play in an increased risk of death over time. The team also examined the role heart disease and stroke play in the link between depression symptoms and increased risk of death. Their study was published in the Journal of the American Geriatrics Society.
The researchers used information from the Three-City Study, a French study that investigated dementia, heart disease, and stroke in people aged 65 and older during five healthcare visits the participants made over 10 years.
At the start of the study, 16 percent of 9,294 participants had a history of heart disease. Most participants were around 73 years old; 37 percent were men.
About 23 percent of participants had symptoms of depression when the study began (28 percent of women and 13 percent of men). Almost 7 percent were taking medication for their depression. At three follow-up visits, the participants were tested again for symptoms of depression.
When the participants were monitored for depression symptoms at several visits over time, symptoms of depression were linked to an increased risk for death, including death from heart disease and stroke. However, those diseases explained only a small percentage of the deaths associated with depression symptoms over time.
The researchers said their study suggested that, for older adults living with depression, preventing heart disease may not be the only factor that will help prevent or delay death. Interestingly, antidepressants were not associated with an increased risk of death in this study.
https://www.sciencedaily.com/releases/2019/02/190206091423.htm
Depression strongly linked to higher long-term risk of early death for both women, men
Science Daily/October 23, 2017
Canadian Medical Association Journal
Despite increased awareness about mental illness, depression remains strongly linked to a higher risk of early death -- and this risk has increased for women in recent years -- according to results from the 60-year Stirling County Study.
"There is less stigma associated with depression, better treatments are available, but depression's link to mortality still persists," said Dr. Stephen Gilman of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health in Bethesda, Maryland. "At first, the association was limited to men, but in later years it was seen for women as well."
The Stirling County Study, begun in 1952 in Atlantic Canada, is well-known internationally as one of the first community-based studies on mental illness. A researcher from the original study, Dr. Jane Murphy with Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, is a coauthor on this latest research study.
An international team of researchers looked at 60 years of mental health data on 3410 adults during 3 periods (1952-1967, 1968-1990 and 1991-2011) from a region in Atlantic Canada and linked the data to deaths in the Canadian Mortality Database. They found that the link between depression and an increased risk of death was observed in all decades of the study among men, whereas it emerged among women beginning in the 1990s. The risk of death associated with depression appeared strongest in the years following a depressive episode, leading the authors to speculate that this risk could be reversed by achieving remission of depression.
The mean age of participants at enrolment in the study was about 49 years. "The lifespan for young adults with depression at age 25 was markedly shorter over the 60-year period, ranging from 10 to 12 fewer years of life in the first group, 4 to 7 years in the second group and 7 to 18 fewer years of life in the 1992 group," says Dr. Ian Colman, Canada Research Chair in the School of Epidemiology, University of Ottawa, Ottawa, Ontario. "Most disturbing is the 50% increase in the risk of death for women with depression between 1992 and 2011."
Though depression has also been linked with poorer diet, lack of exercise, smoking and alcohol consumption -- all factors that can result in chronic health conditions -- these did not explain the increased risk of death associated with depression in this study.
Societal change may help explain the emergent risk of death for women with depression.
"During the last 20 years of the study in which women's risk of death increased significantly, roles have changed dramatically both at home and in the workplace, and many women shoulder multiple responsibilities and expectations," says Dr. Colman.
The authors suggest that family physicians should monitor patients for mood disturbances, especially recurrent episodes of depression, so that they may offer treatment and support.
Limitations include a long interval between participant interviews which prevented determining the exact timing of depression and the participants' experiences of recurrent episodes of depression between interviews.
https://www.sciencedaily.com/releases/2017/10/171023094625.htm