Component of human breast milk enhances cognitive development in babies

February 12, 2020

Science Daily/Children's Hospital Los Angeles

Investigators show that early exposure to a carbohydrate found in breast milk, called 2'FL, positively influences neurodevelopment.

Maternal factors, such as breast milk, have been shown to affect a baby's development, and previous animal studies have determined that a carbohydrate, the oligosaccharide 2'FL found in maternal milk, positively influences neurodevelopment. Now, in the first study done in humans, investigators at Children's Hospital Los Angeles in collaboration with the University of California, San Diego, have shown that 2'FL found in breast milk enhances cognitive development. Findings will be published in PLOS ONE on Feb 12.

In this cohort study of 50 mothers and their babies, investigators analyzed breast milk composition and frequency of feeding at 1 and 6 months of age. Cognitive development was measured at 24 months using the Bayley-III scale, a standardized test of infant and toddler development. The study showed that the amount of 2'FL in breast milk in the first month of feeding was related to significantly higher cognitive development scores in babies by 2 years of age. The amount of 2'FL in breast milk at 6 months of feeding was not related to cognitive outcomes, indicating that early exposure may be more beneficial.

Many studies have reported a positive effect of breastfeeding on cognitive development. "We wanted to specifically identify what was causing this effect," said Michael Goran, PhD, Director of the Diabetes and Obesity Program at The Saban Research Institute of Children's Hospital Los Angeles and senior author on the study.

"Through our high-throughput analytical platform we can quantify oligosaccharides like 2'FL and many others in hundreds of breast milk samples in a short period of time," says study collaborator and co-author Lars Bode, PhD, Professor of Pediatrics and Director of the Mother-Milk-Infant Center of Research Excellence at the University of California, San Diego. "This technology allows us to associate differences in milk composition with specific infant outcomes like cognitive development, validating existing data from preclinical models or generating entirely new hypotheses," Bode adds.

Using a statistical technique called mediation analysis, the investigators were able to independently evaluate the effects of breastfeeding in general, and the effects of the oligosaccharide 2'FL.

"This enhanced cognitive development in the first 2 years of life raises the question of possible long term impact on a child¬-in school and beyond," said Paige Berger, PhD, RD, a postdoctoral research associate at CHLA and the first author of the study.

These observations allowed the team to conclude that the increased neurodevelopment provided by breastfeeding was due primarily to mothers who were producing more 2'FL for the baby to consume.

"We know that there are many different compounds in breast milk and the composition is dynamic -- it changes over time and is highly variable between mothers," Dr. Goran said. "In addition to identifying the impact of oligosaccharide 2'FL, we also wanted to determine the timing of when it is most critical to a child's development."

While the investigators observed neuroenhancement explained by higher 2'FL during the first month of a baby's life, this effect was not observed when looking at 2'FL content of breast milk at the six-month time-point. Being able to identify factors critical to early neurodevelopment offers the possibility for supplementing women's breast milk in individuals who produce lower quantities of this important substance.

"For some women, breastfeeding is a challenge. For those that are not able to breastfeed or can only do so short-term, 2'FL could potentially be offered as an add-on to the nutrition their baby is receiving to better support cognitive development," said Dr. Berger.

https://www.sciencedaily.com/releases/2020/02/200212150143.htm

Longer duration of breastfeeding linked with higher adult IQ and earning ability

March 17, 2015

Science Daily/The Lancet

Longer duration of breastfeeding is linked with increased intelligence in adulthood, longer schooling, and higher adult earnings, a study following a group of almost 3,500 newborns for 30 years.

"The effect of breastfeeding on brain development and child intelligence is well established, but whether these effects persist into adulthood is less clear," explains lead author Dr Bernardo Lessa Horta from the Federal University of Pelotas in Brazil.

"Our study provides the first evidence that prolonged breastfeeding not only increases intelligence until at least the age of 30 years but also has an impact both at an individual and societal level by improving educational attainment and earning ability. What is unique about this study is the fact that, in the population we studied, breastfeeding was not more common among highly educated, high-income women, but was evenly distributed by social class. Previous studies from developed countries have been criticized for failing to disentangle the effect of breastfeeding from that of socioeconomic advantage, but our work addresses this issue for the first time."

Horta and colleagues analysed data from a prospective study of nearly 6000 infants born in Pelotas, Brazil in 1982. Information on breastfeeding was collected in early childhood. Participants were given an IQ test (Wechsler Adult Intelligence Scale, 3rd version) at the average age of 30 years old and information on educational achievement and income was also collected.

Information on IQ and breastfeeding was available for just over half (3493) participants. The researchers divided these subjects into five groups based on the length of time they were breastfed as infants, controlling for 10 social and biological variables that might contribute to the IQ increase including family income at birth, parental schooling, genomic ancestry, maternal smoking during pregnancy, maternal age, birthweight, and delivery type.

While the study showed increased adult intelligence, longer schooling, and higher adult earnings at all duration levels of breastfeeding, the longer a child was breastfed for (up to 12 months), the greater the magnitude of the benefits. For example, an infant who had been breastfed for at least a year gained a full four IQ points (about a third of a standard deviation above the average), had 0.9 years more schooling (about a quarter of a standard deviation above the average), and a higher income of 341 reais per month (equivalent to about one third of the average income level) at the age of 30 years, compared to those breastfed for less than one month.

According to Dr Horta, "The likely mechanism underlying the beneficial effects of breast milk on intelligence is the presence of long-chain saturated fatty acids (DHAs) found in breast milk, which are essential for brain development. Our finding that predominant breastfeeding is positively related to IQ in adulthood also suggests that the amount of milk consumed plays a role."

Writing in a linked Comment, Dr Erik Mortensen from the University of Copenhagen in Denmark says, "With age, the effects of early developmental factors might either be diluted, because of the effects of later environmental factors, or be enhanced, because cognitive ability affects educational attainment and occupational achievements...By contrast, Victora and colleagues' study suggests that the effects of breastfeeding on cognitive development persist into adulthood, and this has important public health implications...However, these findings need to be corroborated by future studies designed to focus on long-term effects and important life outcomes associated with breastfeeding."

http://www.sciencedaily.com/releases/2015/03/150317195937.htm