Impact of Cannabis on Bones Changes with Age
August 16, 2009
Science Daily/University of Edinburgh
Scientists investigating the effects of cannabis on bone health have found that its impact varies dramatically with age.
The study has found that although cannabis could reduce bone strength in young people, it may protect against osteoporosis, a weakening of the bones, in later life.
The team at the University of Edinburgh has shown that a molecule found naturally in the body, which can be activated by cannabis – called the type 1 cannabinoid receptor (CB1) – is key to the development of osteoporosis.
It is known that when CB1 comes into contact with cannabis it has an impact on bone regeneration, but until now it was not clear whether the drug had a positive or negative effect.
Researchers, funded by the Arthritis Research Campaign, investigated this by studying mice that lacked the CB1 receptor. The scientists then used compounds – similar to those in cannabis – that activated the CB1 receptor. They found that compounds increased the rate at which bone tissue was destroyed in the young.
The study also showed, however, that the same compounds decreased bone loss in older mice and prevented the accumulation of fat in the bones, which is known to occur in humans with osteoporosis. The results are published in Cell Metabolism.
Osteoporosis affects up to 30 per cent of women and 12 per cent of men at some point in life.
Stuart Ralston, the Arthritis Research Campaign Professor of Rheumatology at the University of Edinburgh, who led the study, said: "This is an exciting step forward, but we must recognise that these are early results and more tests are needed on the effects of cannabis in humans to determine how the effects differ with age in people.
"We plan to conduct further trials soon and hope the results will help to deliver new treatments that will be of value in the fight against osteoporosis."
https://www.sciencedaily.com/releases/2009/08/090813142341.htm
Cannabis excess linked to bone disease, fractures
October 12, 2016
Science Daily/University of Edinburgh
People who regularly smoke large amounts of cannabis have reduced bone density and are more prone to fractures, research has found.
The study also found that heavy cannabis users have a lower body weight and a reduced body mass index (BMI), which could contribute to thinning of their bones.
Researchers say this could mean heavy users of the drug are at greater risk of osteoporosis in later life.
Scientists at the University of Edinburgh assessed 170 people who smoke cannabis regularly for recreational purposes and 114 non-users.
The team used a specialised x-ray technique called a DEXA scan to measure the bone density of study participants. They found that the bone density of heavy cannabis users was about five per cent lower than cigarette smokers who did not use cannabis.
Fractures were more common in heavy users compared to non-users, the study found. Moderate users, however, showed no difference from non-users.
The researchers defined heavy users as those who reported smoking cannabis on 5000 or more occasions in their lifetime. In this study, however, the average heavy cannabis user had taken the drug more than 47,000 times. Moderate users had, on average, taken the drug about 1000 times.
Smoking cannabis is often associated with increased appetite so the researchers were surprised to find that heavy cannabis users had a lower body weight and BMI than non-users. This could be because cannabis may reduce appetite when taken in large amounts over a long period of time, the team says.
The study is the first to investigate bone health amongst cannabis users. Researchers say further studies are needed to better understand the link between use of the drug and thinning of the bones.
The study -- funded by Arthritis Research UK -- is published in the American Journal of Medicine.
Lead researcher Professor Stuart Ralston, of the University of Edinburgh's Centre for Genomic and Experimental Medicine, said: "We have known for a while that the components of cannabis can affect bone cell function but we had no idea up until now of what this might mean to people who use cannabis on a regular basis.
"Our research has shown that heavy users of cannabis have quite a large reduction in bone density compared with non-users and there is a real concern that this may put them at increased risk of developing osteoporosis and fractures later in life."
https://www.sciencedaily.com/releases/2016/10/161012132657.htm