Stress-related disorders linked to heightened risk of cardiovascular disease

Risk is particularly high during the first year after diagnosis

April 10, 2019

Science Daily/BMJ

Stress related disorders -- conditions triggered by a significant life event or trauma -- may be linked to a heightened risk of cardiovascular disease (CVD), finds a large Swedish study published in The BMJ today.

The risk of severe and acute CVD events, such as cardiac arrest and heart attack, was particularly high in the first six months after diagnosis of a stress related disorder, and within the first year for other types of CVD.

Most people are, at some point during their life, exposed to psychological trauma or stressful life events such as the death of a loved one, a diagnosis of a life threatening illness, natural disasters, or violence, write the authors.

And there is building evidence which suggests that severe stress reactions to significant life events or trauma are linked to the development of CVD.

But previous studies have mainly focused on male veterans or those currently active in the military with posttraumatic stress disorder (PTSD), or PTSD symptoms. And because of the smaller size of these samples, data on the effects of stress reactions on different types of CVD are limited.

So to shed some light on this, researchers used Swedish population and health registers to explore the role of clinically diagnosed PTSD, acute stress reaction, adjustment disorder, and other stress reactions in the development of CVD.

They controlled for family background, medical history, and underlying psychiatric conditions.

The researchers matched 136,637 people from an "exposed cohort" who were diagnosed with a stress related disorder between January 1987 and December 2013 with 171,314 full siblings who were free of stress related disorders and CVD.

For each exposed person, 10 people from the general population who were unaffected by stress related disorders and CVD at the date of diagnosis of the "exposed" patient were randomly selected.

Exposed and unexposed people were then individually matched by birth year and sex.

Severe stress reactions to significant life events or trauma were linked to a heightened risk of several types of CVD, especially during the first year after diagnosis, with a 64% higher risk among people with a stress related disorder compared to their unaffected sibling.

The findings were similar for people with a stress related disorder compared to the general population.

And there was a stronger link between stress related disorders and early onset CVD -- cases of disease which developed before the age of 50 -- than later onset ones.

Out of all studied CVDs, the excess risk during the first year was strongest for heart failure, and for major blood clots (embolism and thrombosis) after one year.

There were similar associations across sex, calendar period, medical history, and family history of CVD. But those who were diagnosed with a stress disorder at a younger age had a heightened risk of CVD.

This is an observational study based on the Swedish population and, as such, can't establish cause. The authors point out evidence from other studies suggesting a biological link between severe stress reactions and cardiovascular disease development. And they can't rule out the role of other unmeasured behavioural factors, such as smoking and alcohol intake.

But they say that their study is the first to explore the association between a number of stress related disorders, including but not limited to PTSD, and several types of CVD using sibling-based comparisons, among both men and women.

And doctors need to be aware of the "robust" link between stress related disorders and a higher subsequent risk of cardiovascular disease, particularly during the months after diagnosis, they add.

"These findings call for enhanced clinical awareness and, if verified, monitoring or early intervention among patients with recently diagnosed stress related disorders," they conclude.

In a linked editorial, Professor Simon Bacon from Concordia University in Canada, says that the design of the study "allows us to make reasonable assumptions about the similarity of the environment, lifestyles, and health behaviours between those with a disorder and their paired siblings without one. Such assumptions allow inferences about other alternative potential pathways linking these disorders to CVD outcomes."

In the future, well designed studies evaluating more appropriate interventions will be critical, not only to confirm the inferences of the new study but also to provide real benefits to patients," he concludes.

https://www.sciencedaily.com/releases/2019/04/190410210000.htm

Here’s how stress may be making you sick

January 10, 2018

Michigan State University

A researcher is providing new insight into how certain types of stress interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and disease.

The federally funded study, published in the Journal of Leukocyte Biology, showed how a stress receptor, known as corticotropin-releasing factor, or CRF1, can send signals to certain immune cells, called mast cells, and control how they defend the body.

During the study, Moeser compared the histamine responses of mice to two types of stress conditions -- psychological and allergic -- where the immune system becomes overworked. One group of mice was considered "normal" with CRF1 receptors on their mast cells and the other group had cells that lacked CRF1.

"While the 'normal' mice exposed to stress exhibited high histamine levels and disease, the mice without CRF1 had low histamine levels, less disease and were protected against both types of stress," Moeser said. "This tells us that CRF1 is critically involved in some diseases initiated by these stressors."

The CRF1-deficient mice exposed to allergic stress had a 54 percent reduction in disease, while those mice who experienced psychological stress had a 63 percent decrease.

The results could change the way everyday disorders such as asthma and the debilitating gastrointestinal symptoms of irritable bowel syndrome are treated.

"We all know that stress affects the mind-body connection and increases the risk for many diseases," Moeser said. "The question is, how?"

"This work is a critical step forward in decoding how stress makes us sick and provides a new target pathway in the mast cell for therapies to improve the quality of life of people suffering from common stress-related diseases."

https://www.sciencedaily.com/releases/2018/01/180110132958.htm