Here comes the sun to lower your blood pressure
January 17, 2014
Science Daily/University of Southampton
Exposing skin to sunlight may help to reduce blood pressure and thus cut the risk of heart attack and stroke, a study published suggests. Research shows that sunlight alters levels of the small messenger molecule, nitric oxide (NO) in the skin and blood, reducing blood pressure.
The results suggest that UVA exposure dilates blood vessels, significantly lowers blood pressure, and alters NO metabolite levels in the circulation, without changing vitamin D levels. Further experiments indicate that pre-formed stores of NO in the upper skin layers are involved in mediating these effects. The data are consistent with the seasonal variation of blood pressure and cardiovascular risk at temperate latitudes.
Professor Feelisch adds: "These results are significant to the ongoing debate about potential health benefits of sunlight and the role of Vitamin D in this process. It may be an opportune time to reassess the risks and benefits of sunlight for human health and to take a fresh look at current public health advice. Avoiding excess sunlight exposure is critical to prevent skin cancer, but not being exposed to it at all, out of fear or as a result of a certain lifestyle, could increase the risk of cardiovascular disease. Perhaps with the exception of bone health, the effects of oral vitamin D supplementation have been disappointing.
http://www.sciencedaily.com/releases/2014/01/140117090139.htm
Call to scientists: Stop excluding left-handed people from scientific studies
February 13, 2014
Science Daily/Radboud University Nijmegen
Left-handed people really do have different brains and genes from right-handed people. Yet left-handed people are almost never included as study subjects in scientific research. Therefore in a new article, a call is launched for more research into left-handed people.
Left-handed people are rarely included as study subjects for brain or genetic research because the differences with right-handed people cause noise in the final results. However, left-handed people form about ten percent of the entire population and their brains and genes contain interesting information about the functioning of both halves of the brain as well as about several psychiatric disorders. 'Research into left-handed people is therefore interesting because of the noise they cause', thinks neuroscientist Roel Willems from the Donders Institute for Brain, Cognition and Behaviour at Radboud University Nijmegen. With the opinion article he calls upon his fellow researchers to stop excluding left-handed people from studies.
Missed chance for the neurosciences 'One of our studies from 2009 clearly shows why research into left-handed people is so vital', says Willems. 'According to the textbooks, facial recognition takes place in the right half of the brain. Our research revealed that the same process takes place in both halves of the brain in the case of left-handed people, but with the same final outcome. That is a fundamental difference. And left-handed people might process other important information differently as well. The minimal amount of research into this is, in my view, a missed chance for the neurosciences.
http://www.sciencedaily.com/releases/2014/02/140213112640.htm
Does more stress equal more headaches?
February 19, 2014
Science Daily/American Academy of Neurology (AAN)
A new study provides evidence for what many people who experience headache have long suspected—having more stress in your life leads to more headaches.
"These results show that this is a problem for everyone who suffers from headaches and emphasize the importance of stress management approaches for people with migraine and those who treat them," said study author Sara H. Schramm, MD, of University Hospital of University Duisburg-Essen in Germany. "The results add weight to the concept that stress can be a factor contributing to the onset of headache disorders, that it accelerates the progression to chronic headache, exacerbates headache episodes, and that the headache experience itself can serve as a stressor."
http://www.sciencedaily.com/releases/2014/02/140219162732.htm
Brain differences linked to insomnia identified by researchers
February 28, 2014
Science Daily/Johns Hopkins Medicine
Researchers report that people with chronic insomnia show more plasticity and activity than good sleepers in the part of the brain that controls movement. "Insomnia is not a nighttime disorder," says study leader, Rachel E. Salas, M.D., an assistant professor of neurology. "It's a 24-hour brain condition, like a light switch that is always on. Our research adds information about differences in the brain associated with it." The researchers say they hope their study opens the door to better diagnosis and treatment of the most common and often intractable sleep disorder that affects an estimated 15 percent of the United States population.
Because lack of sleep at night has been linked to decreased memory and concentration during the day, Salas and her colleagues suspected that the brains of good sleepers could be more easily retrained. The results, however, were the opposite. The researchers found much more plasticity in the brains of those with chronic insomnia.
Salas says the origins of increased plasticity in insomniacs are unclear, and it is not known whether the increase is the cause of insomnia. It is also unknown whether this increased plasticity is beneficial, the source of the problem or part of a compensatory mechanism to address the consequences of sleep deprivation associated with chronic insomnia. Patients with chronic phantom pain after limb amputation and with dystonia, a neurological movement disorder in which sustained muscle contractions cause twisting and repetitive movements, also have increased brain plasticity in the motor cortex, but to detrimental effect.
Salas says it is possible that the dysregulation of arousal described in chronic insomnia -- increased metabolism, increased cortisol levels, constant worrying -- might be linked to increased plasticity in some way. Diagnosing insomnia is solely based on what the patient reports to the provider; there is no objective test. Neither is there a single treatment that works for all people with insomnia. Treatment can be a hit or miss in many patients.
http://www.sciencedaily.com/releases/2014/02/140228155757.htm
Outbursts of anger linked to greater risk of heart attacks and strokes
March 3, 2014
Science Daily/European Society of Cardiology (ESC)
Outbursts of anger may trigger heart attacks, strokes and other cardiovascular problems in the two hours immediately afterwards, according to the first study to systematically evaluate previous research into the link between the extreme emotion and all cardiovascular outcomes. The researchers conclude: conclude: “Given the lessons we have learned from trying to treat depression after MI, treating anger in isolation is unlikely to be impactful. Instead, a broader and more comprehensive approach to treating acute and chronic mental stress, and its associated psychological stressors, is likely to be needed to heal a hostile heart.”
The remaining question in all of these studies, however, is how to prevent these dangerous anger episodes." They conclude: "Given the lessons we have learned from trying to treat depression after MI, treating anger in isolation is unlikely to be impactful. Instead, a broader and more comprehensive approach to treating acute and chronic mental stress, and its associated psychological stressors, is likely to be needed to heal a hostile heart."
http://www.sciencedaily.com/releases/2014/03/140303211324.htm
Light affects our brain's performance: Photic memory for executive brain responses
March 10, 2014
Science Daily/University of Liège
It has long been known that light exerts powerful effects on the brain and on our well-being. Light is not only required for vision but is also essential for a wide range of “non-visual” functions including synchronization of our biological clock to the 24h day-night cycle. A novel photoreceptor has now been shown to be an essential component for relaying light information to a set of so-called non-visual centers in the brain. Continuous changes in light throughout the day also change us, new research suggests.
The phenomenon of prior light effects on a subsequent response to light is typical of melonopsin as well as certain photopigments of invertebrate and plant, and has been referred to as a "photic memory." Humans may therefore have an invertebrate or plant-like machinery within the eyes that participates to regulate cognition. It may also explain what human chronobiologists have described as "previous light history effects," a form of long term adaptation to previous lighting conditions.
These findings emphasize the importance of light for human cognitive brain functions and constitute compelling evidence in favor of a cognitive role for melanopsin. More generally, the continuous change of light throughout the day also changes us. Ultimately, these findings argue for the use and design of lighting systems to optimize cognitive performance.
http://www.sciencedaily.com/releases/2014/03/140310152023.htm
Chronic sleep disturbance could trigger onset of Alzheimer's
March 17, 2014
Science Daily/Temple University
People who experience chronic sleep disturbance could face an earlier onset of dementia and Alzheimer’s, results from a new pre-clinical study indicate. "We can conclude from this study that chronic sleep disturbance is an environmental risk factor for Alzheimer's disease," a co-author said. "But the good news is that sleep disturbances can be easily treated, which would hopefully reduce the Alzheimer's risk."
"We can conclude from this study that chronic sleep disturbance is an environmental risk factor for Alzheimer's disease," he said. "But the good news is that sleep disturbances can be easily treated, which would hopefully reduce the Alzheimer's risk."
http://www.sciencedaily.com/releases/2014/03/140317155205.htm
Health-care professionals should prescribe sleep to prevent metabolic disorders
March 24, 2014
Science Daily/The Lancet
Evidence increasingly suggests that insufficient or disturbed sleep is associated with metabolic disorders such as type 2 diabetes and obesity, and addressing poor quality sleep should be a target for the prevention -- and even treatment -- of these disorders. Addressing some types of sleep disturbance -- such as sleep apnea -- may have a directly beneficial effect on patients' metabolic health, say the authors. But a far more common problem is people simply not getting enough sleep, particularly due to the increased use of devices such as tablets and portable gaming devices.
Although a number of epidemiological studies point to a clear association between poor quality sleep and metabolic disorders, until recently, the reason for this association was not clear. However, experimental studies are starting to provide evidence that there is a direct causal link between loss of sleep and the body's ability to metabolize glucose, control food intake, and maintain its energy balance.
According to the study authors, "These findings open up new strategies for targeted interventions aimed at the present epidemic of the metabolic syndrome and related diseases. Ongoing and future studies will show whether interventions to improve sleep duration and quality can prevent or even reverse adverse metabolic traits. Meanwhile, on the basis of existing evidence, health care professionals can be safely recommended to motivate their patients to enjoy sufficient sleep at the right time of day."
http://www.sciencedaily.com/releases/2014/03/140324200507.htm
Migraine attacks increase following stress 'let-down'
March 26, 2014
Science Daily/Montefiore Medical Center
Migraine sufferers who experienced reduced stress from one day to the next are at significantly increased risk of migraine onset on the subsequent day. "This study highlights the importance of stress management and healthy lifestyle habits for people who live with migraine," said a study co-author. "It is important for people to be aware of rising stress levels and attempt to relax during periods of stress rather than allowing a major build up to occur. This could include exercising or attending a yoga class or may be as simple as taking a walk or focusing on one's breath for a few minutes."
"This study highlights the importance of stress management and healthy lifestyle habits for people who live with migraine," said Dawn C. Buse, Ph.D., director, Behavioral Medicine, Montefiore Headache Center, associate professor, Clinical Neurology, Einstein, and study co-author. "It is important for people to be aware of rising stress levels and attempt to relax during periods of stress rather than allowing a major build up to occur. This could include exercising or attending a yoga class or may be as simple as taking a walk or focusing on one's breath for a few minutes."
http://www.sciencedaily.com/releases/2014/03/140326181915.htm
Sleep may stop chronic pain sufferers from becoming zombies
March 27, 2014
Science Daily/University of Warwick
Chronic pain sufferers could be kept physically active by improving the quality of their sleep, new research suggests. The study found that sleep was a worthy target for treating chronic pain and not only as an answer to pain-related insomnia.
Considering the implications of the study Dr Tang said that "the prospect of promoting physical activity by regulating sleep may offer a novel solution to an old problem."
"The current study identified sleep quality, rather than pain and low mood, as a key driver of physical activity the next day. The finding challenges the conventional target of treatment being primarily focused on changing what patients do during the day. Sleep has a naturally recuperative power that is often overlooked in pain management. A greater treatment emphasis on sleep may help patients improve their daytime functioning and hence their quality of life" argued Dr Tang.
http://www.sciencedaily.com/releases/2014/03/140327101401.htm
Chronic stress in early life causes anxiety, aggression in adulthood
March 27, 2014
Science Daily/Cold Spring Harbor Laboratory
In experiments to assess the impacts of social stress upon adolescent mice, both at the time they are experienced and during adulthood, a laboratory team conducted many different kinds of stress tests and means of measuring their impacts. The research indicates that a 'hostile environment in adolescence disturbs psychoemotional state and social behaviors of animals in adult life,' the team says.
"The tests assessed levels of anxiety, depression, and capacity to socialize and communicate with an unfamiliar partner," explains Enikolopov. These experiments showed that in young mice chronic social defeat induced high levels of anxiety helplessness, diminished social interaction, and diminished ability to communicate with other young animals. Stressed mice also had less new nerve-cell growth (neurogenesis) in a portion of the hippocampus known to be affected in depression: the subgranular zone of the dentate gyrus.
http://www.sciencedaily.com/releases/2014/03/140327123654.htm
Circadian clock like an orchestra with many conductors
March 27, 2014
Science Daily/University of Michigan
You've switched to the night shift and your weight skyrockets, or you wake at 7 a.m. on weekdays but sleep until noon on weekends -- a social jet lag can fog your Saturday and Sunday. Life runs on rhythms driven by circadian clocks, and disruption of these cycles is associated with serious physical and emotional problems.
"The finding shows that instead of the entire orchestra following a single conductor, part of the orchestra is following a different conductor or not listening at all," Shafer said. The findings suggest that instead of a group of master pacemaker neurons, the clock network consists of many independent clocks, each of which drives rhythms in activity. Shafer and Yao suspect that a similar organization will be found in mammals, as well.
"A better understanding of the circadian clock mechanisms will be critical for attempts to alleviate the adverse effects associated with circadian disorders," Yao said.
Disrupting the circadian clock through shift work is associated with diabetes, obesity, stress, heart disease, mood disorders and cancer, among other disorders, Yao says. The International Agency for Research on Cancer classified shift work that disrupts circadian rhythms as a human carcinogen equal to cancer-causing ultraviolet radiation.
http://www.sciencedaily.com/releases/2014/03/140327142443.htm
Want spring allergy relief? Avoid stress
April 1, 2014
Science Daily/American College of Allergy, Asthma and Immunology (ACAAI)
Stress doesn’t cause allergies, but easing your mind might mean less allergy flare-ups this spring. According to a study, allergy sufferers with persistent stress experience more allergy flares. "Stress can cause several negative effects on the body, including causing more symptoms for allergy sufferers," said an allergist.
While there were no significant findings between allergy flares and stress on the same day, a number of sufferers reported allergy flares within days of increased daily stress. "Symptoms, such as sneezing, runny nose and watery eyes can cause added stress for allergy sufferers, and may even be the root of stress for some," said Dr. Patterson. "While alleviating stress won't cure allergies, it may help decrease episodes of intense symptoms."
http://www.sciencedaily.com/releases/2014/04/140401101420.htm
Controlling brain waves to improve vision
April 24, 2014
Science Daily/Beckman Institute for Advanced Science and Technology
A novel technique to test brain waves is being used to see how the brain processes external stimuli that do and don't reach our awareness. "When we have different things competing for our attention, we can only be aware of so much of what we see," said a researcher on the study. "For example, when you're driving, you might really be concentrating on obeying traffic signals." But say there's an unexpected event: an emergency vehicle, a pedestrian -- will you actually see the unexpected, or will you be so focused on your initial task that you don't notice?
By focusing your attention and concentrating more fully on what you are experiencing, however, the executive function of the brain can come into play and provide "top-down" control -- putting a brake on the alpha waves, thus allowing you to see things that you might have missed in a more relaxed state.
"We found that the same brain regions known to control our attention are involved in suppressing the alpha waves and improving our ability to detect hard-to-see targets," said Diane Beck, a member of the Beckman's Cognitive Neuroscience Group, and one of the study's authors.
"Knowing where the waves originate means we can target that area specifically with electrical stimulation" said Mathewson. "Or we can also give people moment-to-moment feedback, which could be used to alert drivers that they are not paying attention and should increase their focus on the road ahead, or in other situations alert students in a classroom that they need to focus more, or athletes, or pilots and equipment operators."
http://www.sciencedaily.com/releases/2014/04/140424170552.htm
How does stress increase risk for stroke, heart attack?
May 5, 2014
Science Daily/Elsevier
Scientists have shown that anger, anxiety, and depression not only affect the functioning of the heart, but also increase the risk for heart disease. Stroke and heart attacks are the end products of progressive damage to blood vessels supplying the heart and brain, a process called atherosclerosis. Atherosclerosis progresses when there are high levels of chemicals in the body called pro-inflammatory cytokines. It is thought that persisting stress increases the risk for atherosclerosis and cardiovascular disease by evoking negative emotions that, in turn, raise the levels of pro-inflammatory chemicals in the body.
"These new findings agree with the popular belief that emotions are connected to heart health," said Gianaros. "We think that the mechanistic basis for this connection may lie in the functioning of brain regions important for regulating both emotion and inflammation."
These findings may have implications for brain-based prevention and intervention efforts to improve heart health and protect against heart disease."
http://www.sciencedaily.com/releases/2014/05/140505104403.htm
Stress degrades sperm quality
May 29, 2014
Science Daily/Columbia University's Mailman School of Public Health
Psychological stress is harmful to sperm and semen quality, affecting its concentration, appearance, and ability to fertilize an egg, according to a study. It is not fully understood how stress affects semen quality. It may trigger the release of steroid hormones called glucocorticoids, which in turn could blunt levels of testosterone and sperm production. Another possibility is oxidative stress, which has been shown to affect semen quality and fertility.
"Stress has long been identified as having an influence on health. Our research suggests that men's reproductive health may also be affected by their social environment," says Teresa Janevic, PhD, the study's first author and an assistant professor at the Rutgers School of Public Health.
http://www.sciencedaily.com/releases/2014/05/140529100719.htm
Sleep after learning strengthens connections between brain cells and memory
June 5, 2014
Science Daily/NYU Langone Medical Center / New York University School of Medicine
Researchers show for the first time that sleep after learning encourages the growth of dendritic spines, the tiny protrusions from brain cells that connect to other brain cells and facilitate the passage of information across synapses, the junctions at which brain cells meet.
The findings, in mice, provide important physical evidence in support of the hypothesis that sleep helps consolidate and strengthen new memories, and show for the first time how learning and sleep cause physical changes in the motor cortex, a brain region responsible for voluntary movements.
"We've known for a long time that sleep plays an important role in learning and memory. If you don't sleep well you won't learn well," says senior investigator Wen-Biao Gan, PhD, professor of neuroscience and physiology and a member of the Skirball Institute of Biomolecular Medicine at NYU Langone Medical Center. "But what's the underlying physical mechanism responsible for this phenomenon? Here we've shown how sleep helps neurons form very specific connections on dendritic branches that may facilitate long-term memory. We also show how different types of learning form synapses on different branches of the same neurons, suggesting that learning causes very specific structural changes in the brain."
On the cellular level, sleep is anything but restful: Brain cells that spark as we digest new information during waking hours replay during deep sleep, also known as slow-wave sleep, when brain waves slow down and rapid-eye movement, as well as dreaming, stops. Scientists have long believed that this nocturnal replay helps us form and recall new memories, yet the structural changes underpinning this process have remained poorly understood.
To shed light on this process, Dr. Gan and colleagues employed mice genetically engineered to express a fluorescent protein in neurons. Using a special laser-scanning microscope that illuminates the glowing fluorescent proteins in the motor cortex, the scientists were then able to track and image the growth of dendritic spines along individual branches of dendrites before and after mice learned to balance on a spin rod. Over time mice learned how to balance on the rod as it gradually spun faster. "It's like learning to ride a bike," says Dr. Gan. "Once you learn it, you never forget."
After documenting that mice, in fact, sprout new spines along dendritic branches, within six hours after training on the spinning rod, the researchers set out to understand how sleep would impact this physical growth. They trained two sets of mice: one trained on the spinning rod for an hour and then slept for 7 hours; the second trained for the same period of time on the rod but stayed awake for 7 hours. The scientists found that the sleep-deprived mice experienced significantly less dendritic spine growth than the well-rested mice. Furthermore, they found that the type of task learned determined which dendritic branches spines would grow.
Running forward on the spinning rod, for instance, produced spine growth on different dendritic branches than running backward on the rod, suggesting that learning specific tasks causes specific structural changes in the brain.
"Now we know that when we learn something new, a neuron will grow new connections on a specific branch," says Dr. Gan. "Imagine a tree that grows leaves (spines) on one branch but not another branch. When we learn something new, it's like we're sprouting leaves on a specific branch."
Finally, the scientists showed that brain cells in the motor cortex that activate when mice learn a task reactivate during slow-wave deep sleep. Disrupting this process, they found, prevents dendritic spine growth. Their findings offer an important insight into the functional role of neuronal replay -- the process by which the sleeping brain rehearses tasks learned during the day -- observed in the motor cortex.
"Our data suggest that neuronal reactivation during sleep is quite important for growing specific connections within the motor cortex," Dr. Gan adds.
http://www.sciencedaily.com/releases/2014/06/140605141849.htm
Couples sleep in sync when wife is satisfied with their marriage
June 5, 2014
Science Daily/American Academy of Sleep Medicine
Couples are more likely to sleep in sync when the wife is more satisfied with their marriage. Results show that overall synchrony in sleep-wake schedules among couples was high, as those who slept in the same bed were awake or asleep at the same time about 75 percent of the time. When the wife reported higher marital satisfaction, the percent of time the couple was awake or asleep at the same time was greater.
"The sleep of married couples is more in sync on a minute-by-minute basis than the sleep of random individuals," said Gunn. "This suggests that our sleep patterns are regulated not only by when we sleep, but also by with whom we sleep."
http://www.sciencedaily.com/releases/2014/06/140605141857.htm
Insomnia: Sleep loss causes brain vulnerability to toxic elements
June 10, 2014
Science Daily/Investigación y Desarrollo
In search of the answer to why do we sleep, researcher have now revealed that chronic sleep loss can cause certain neurotoxic molecules, which normally circulate in the blood, to be transported to the central nervous system and interfere with the function of neurons. The longer the insomnia, the more junctions of cerebral blood vessels begin to degrade.
http://www.sciencedaily.com/releases/2014/06/140610101316.htm
Poor cardiovascular health linked to memory, learning deficits
June 11, 2014
Science Daily/American Heart Association
People with poor cardiovascular health have a substantially higher incidence of cognitive impairment. Better cardiovascular health was more common in men and among people with higher education and higher income. The incidence of mental impairment was found more commonly in those with a lower income, who lived in the 'stroke belt' or had cardiovascular disease.
http://www.sciencedaily.com/releases/2014/06/140611170956.htm