Late night snacks may hurt your workplace performance

April 7, 2021

Science Daily/North Carolina State University

A recent study finds that unhealthy eating behaviors at night can make people less helpful and more withdrawn the next day at work.

"For the first time, we have shown that healthy eating immediately affects our workplace behaviors and performance," says Seonghee "Sophia" Cho, corresponding author of the study and an assistant professor of psychology at North Carolina State University. "It is relatively well established that other health-related behaviors, such as sleep and exercise, affect our work. But nobody had looked at the short-term effects of unhealthy eating."

Fundamentally, the researchers had two questions: Does unhealthy eating behavior affect you at work the next day? And, if so, why?

For the study, researchers had 97 full-time employees in the United States answer a series of questions three times a day for 10 consecutive workdays. Before work on each day, study participants answered questions related to their physical and emotional well-being. At the end of each workday, participants answered questions about what they did at work. In the evening, before bed, participants answered questions about their eating and drinking behaviors after work.

In the context of the study, researchers defined "unhealthy eating" as instances when study participants felt they'd eaten too much junk food; when participants felt they'd had too much to eat or drink; or when participants reporting having too many late-night snacks.

The researchers found that, when people engaged in unhealthy eating behaviors, they were more likely to report having physical problems the next morning. Problems included headaches, stomachaches and diarrhea. In addition, when people reported unhealthy eating behaviors, they were also more likely to report emotional strains the next morning -- such as feeling guilty or ashamed about their diet choices. Those physical and emotional strains associated with unhealthy eating were, in turn, related to changes in how people behaved at work throughout the day.

Essentially, when people reported physical or emotional strains associated with unhealthy eating, they were also more likely to report declines in "helping behavior" and increases in "withdrawal behavior." Helping behavior at work refers to helping colleagues and going the extra mile when you don't have to, such as assisting a co-worker with a task that is not your responsibility. Withdrawal behavior refers to avoiding work-related situations, even though you're at your workplace.

The researchers also found that people who were emotionally stable -- meaning people who are better able to cope with stress because they're less emotionally volatile -- suffered fewer adverse effects from unhealthy eating. Not only were emotionally stable people less likely to have physical or emotional strains after unhealthy eating, their workplace behaviors were also less likely to change even when they reported physical or emotional strains.

"The big takeaway here is that we now know unhealthy eating can have almost immediate effects on workplace performance," Cho says. "However, we can also say that there is no single 'healthy' diet, and healthy eating isn't just about nutritional content. It may be influenced by an individual's dietary needs, or even by when and how they're eating, instead of what they're eating.

"Companies can help to address healthy eating by paying more attention to the dietary needs and preferences of their employees and helping to address those needs, such as through on-site dining options. This can affect both the physical and mental health of their employees -- and, by extension, their on-the-job performance."

The researchers also pointed to a variety of research questions that could be addressed moving forward.

"One confounding variable is that the way our questions were phrased, we may be capturing both unhealthy eating behaviors and unhealthy drinking behaviors related to alcohol," Cho says.

"That's something we will want to tease out moving forward. And while we focused on evening diet, it would be interesting to look at what people are eating at other times of day. Are there specific elements of diet that affect behavioral outcomes -- such as sugar or caffeine content? Can there be positive effects of unhealthy eating, such as when people eat comfort foods to help cope with stress? This promises to be a rich field of study."

https://www.sciencedaily.com/releases/2021/04/210407135755.htm

Tired at the office? Take a quick break; your work will benefit

March 16, 2021

Science Daily/North Carolina State University

Recent research shows that people are more likely to take "microbreaks" at work on days when they're tired -- but that's not a bad thing. The researchers found microbreaks seem to help tired employees bounce back from their morning fatigue and engage with their work better over the course of the day.

At issue are microbreaks, which are short, voluntary and impromptu respites in the workday. Microbreaks include discretionary activities such as having a snack, chatting with a colleague, stretching or working on a crossword puzzle.

"A microbreak is, by definition, short," says Sophia Cho, co-author of a paper on the work and an assistant professor of psychology at North Carolina State University. "But a five-minute break can be golden if you take it at the right time. Our study shows that it is in a company's best interest to give employees autonomy in terms of taking microbreaks when they are needed -- it helps employees effectively manage their energy and engage in their work throughout the day."

The new paper is based on two studies that explored issues related to microbreaks in the workday. Specifically, the studies were aimed at improving our understanding of how people boost or maintain their energy levels throughout the day in order to engage with work even when they start the day already exhausted. The studies also examined which factors might play a role in determining whether people took microbreaks, or what they did during those microbreaks.

The first study surveyed 98 workers in the United States. Study participants were asked to fill out two surveys per day for 10 consecutive workdays. The surveys were completed in the morning and at the end of workday. The second study included 222 workers in South Korea. This study had participants complete three surveys per day for five workdays. Study participants completed the surveys in the morning, after lunch and at the end of the workday.

Survey questions in both studies were aimed at collecting data about each study participant's sleep quality, levels of fatigue, as well as their engagement with their work and their experiences at the workplace that day. In the studies, the researchers analyzed the survey data with statistical tools to examine day-to-day fluctuations in sleep quality, fatigue, work behavior and engagement in varying types of microbreaks.

The results were straightforward: on days that people were already fatigued when they arrived at work, they tended to take microbreaks more frequently. And taking microbreaks helped them maintain their energy level. This, in turn, helped them meet work demands and engage with work better.

"Basically, microbreaks help you manage your energy resources over the course of the day -- and that's particularly beneficial on days when you're tired," Cho says.

In addition, the researchers found that people were more likely to take microbreaks if they felt their employer cared about the health and well-being of its workers.

"When people think their employer cares about their health, they feel more empowered to freely make decisions about when to take microbreaks and what type of microbreaks to take," Cho says. "And that is ultimately good for both the employer and the employee."

https://www.sciencedaily.com/releases/2021/03/210316132124.htm

Insights on how night shift work increases cancer risk

March 8, 2021

Science Daily/Washington State University

New clues as to why night shift workers are at increased risk of developing certain types of cancer are presented in a new study conducted at Washington State University Health Sciences Spokane.

Published online in the Journal of Pineal Research, the study involved a controlled laboratory experiment that used healthy volunteers who were on simulated night shift or day shift schedules. Findings from the study suggest that night shifts disrupt natural 24-hour rhythms in the activity of certain cancer-related genes, making night shift workers more vulnerable to damage to their DNA while at the same time causing the body's DNA repair mechanisms to be mistimed to deal with that damage.

Though more research still needs to be done, these discoveries could someday be used to help prevent and treat cancer in night shift workers.

"There has been mounting evidence that cancer is more prevalent in night shift workers, which led the World Health Organization's International Agency for Research on Cancer to classify night shift work as a probable carcinogenic," said co-corresponding author Shobhan Gaddameedhi, an associate professor formerly with the WSU College of Pharmacy and Pharmaceutical Sciences and now with North Carolina State University's Biological Sciences Department and Center for Human Health and the Environment. "However, it has been unclear why night shift work elevates cancer risk, which our study sought to address."

Studying the rhythms in cancer-related genes

As part of a partnership between the WSU Sleep and Performance Research Center and the U.S. Department of Energy's Pacific Northwest National Laboratory (PNNL), Gaddameedhi and other WSU scientists worked with bioinformatics experts at PNNL to study the potential involvement of the biological clock, the body's built-in mechanism that keeps us on a 24-hour night and day cycle. Though there is a central biological clock in the brain, nearly every cell in the body also has its own built-in clock. This cellular clock involves genes known as clock genes that are rhythmic in their expression, meaning their activity levels vary with the time of day or night. The researchers hypothesized that the expression of genes associated with cancer might be rhythmic, too, and that night shift work might disrupt the rhythmicity of these genes.

To test this, they conducted a simulated shift work experiment that had 14 participants spend seven days inside the sleep laboratory at WSU Health Sciences Spokane. Half of them completed a three-day simulated night shift schedule, while the other half were on a three-day simulated day shift schedule. After completing their simulated shifts, all participants were kept in a constant routine protocol that is used to study humans' internally generated biological rhythms independent of any external influences. As part of the protocol, they were kept awake for 24 hours in a semi-reclined posture under constant light exposure and room temperature and were given identical snacks every hour. Every three hours a blood sample was drawn.

Analyses of white blood cells taken from the blood samples showed that the rhythms of many of the cancer-related genes were different in the night shift condition compared to the day shift condition. Notably, genes related to DNA repair that showed distinct rhythms in the day shift condition lost their rhythmicity in the night shift condition.

The researchers then looked at what the consequences of the changes in the expression of cancer-related genes might be. They found that white blood cells isolated from the blood of night shift participants showed more evidence of DNA damage than those of day shift participants. What's more, after the researchers exposed isolated white blood cells to ionizing radiation at two different times of day, cells that were radiated in the evening showed increased DNA damage in the night shift condition as compared to the day shift condition. This meant that white blood cells from night shift participants were more vulnerable to external damage from radiation, a known risk factor for DNA damage and cancer.

"Taken together, these findings suggest that night shift schedules throw off the timing of expression of cancer-related genes in a way that reduces the effectiveness of the body's DNA repair processes when they are most needed," said co-corresponding author Jason McDermott, a computational scientist with the Pacific Northwest National Laboratory's Biological Sciences Division.

Potential for improved prevention, treatment

The researchers' next step is to conduct the same experiment with real-world shift workers who have been consistently on day or night shifts for many years to determine whether in night workers the unrepaired DNA damage builds up over time, which could ultimately increase the risk of cancer. If what happens in real-world shift workers is consistent with the current findings, this work could eventually be used to develop prevention strategies and drugs that could address the mistiming of DNA repair processes. It could also be the basis for strategies to optimize the timing of cancer therapy so that treatment is administered when effectiveness is greatest and side effects are minimal, a procedure called chronotherapy that would need to be fine-tuned to the internal rhythms of night workers.

"Night shift workers face considerable health disparities, ranging from increased risks of metabolic and cardiovascular disease to mental health disorders and cancer," said co-senior author Hans Van Dongen, a professor in the WSU Elson S. Floyd College of Medicine and director of the WSU Sleep and Performance Research Center. "It is high time that we find diagnosis and treatment solutions for this underserved group of essential workers so that the medical community can address their unique health challenges."

https://www.sciencedaily.com/releases/2021/03/210308091744.htm

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Hypnosis changes the way our brain processes information

March 26, 2021

Science Daily/University of Turku

During a normal waking state, information is processed and shared by various parts within our brain to enable flexible responses to external stimuli. Researchers from the University of Turku, Finland, found that during hypnosis the brain shifted to a state where individual brain regions acted more independently of each other.

"In a normal waking state, different brain regions share information with each other, but during hypnosis this process is kind of fractured and the various brain regions are no longer similarly synchronised," describes researcher Henry Railo from the Department of Clinical Neurophysiology at the University of Turku.

The finding shows that the brain may function quite differently during hypnosis when compared to a normal waking state. This is interesting because the extent to which hypnosis modifies neural processing has been hotly debated in the field. The new findings also help to better understand which types of changes and mechanisms may explain the experiential and behavioural alterations attributed to hypnosis, such as liability to suggestions.

The study focused on a single person who has been extensively studied earlier and been shown to react strongly to hypnotic suggestions. During hypnosis, this person can experience phenomena that are not typically possible in a normal waking state, such as vivid and controlled hallucinations.

"Even though these findings cannot be generalised before a replication has been conducted on a larger sample of participants, we have demonstrated what kind of changes happen in the neural activity of a person who reacts to hypnosis particularly strongly," clarifies Jarno Tuominen, Senior Researcher at the Department of Psychology and Speech-Language Pathology.

Hypnosis Studied for the First Time with New Method

The study was conducted by tracking how a magnetically-induced electrical current spread throughout the brain during hypnosis and normal waking state. This method has been previously used to measure system-level changes in the brain in various states of consciousness, such as anaesthesia, coma, and sleep. This is the first time such a method has been used to assess hypnosis.

During the study, the participant sat still with eyes closed, alternatively either hypnotised or in a normal waking state. Hypnosis was induced via a single-word cue, and the different conditions were identical in every other respect.

"This allowed us to control the possible effects of the experimental setup or other factors, such as alertness," Tuominen explains.

https://www.sciencedaily.com/releases/2021/03/210326122743.htm

Leisure physical activity is linked with health benefits but work activity is not

April 8, 2021

Science Daily/European Society of Cardiology

The first large study showing that leisure time physical activity and occupational physical activity have opposite, and independent, associations with cardiovascular disease risk and longevity is published today in European Heart Journal, a journal of the European Society of Cardiology (ESC).

"We adjusted for multiple factors in our analysis, indicating that the relationships were not explained by lifestyle, health conditions or socioeconomic status," said study author Professor Andreas Holtermann of the National Research Centre for the Working Environment, Copenhagen, Denmark.

The World Health Organization (WHO) recommends physical activity during both recreation and work to improve health.* Previous studies have suggested that occupational activity is related to an increased risk for heart disease and mortality but have been too small to fully explain whether this was due to the manual work or because employees had unhealthy lifestyles or low socioeconomic status (e.g. low level of education).

This study included 104,046 women and men aged 20-100 years from the Copenhagen General Population Study with baseline measurements in 2003-2014. Participants completed questionnaires about activity during leisure and employment and were categorised as low, moderate, high, or very high activity for each.

During a median follow-up of 10 years, there were 9,846 (9.5%) deaths from all causes and 7,913 (7.6%) major adverse cardiovascular events (MACE, defined as fatal and nonfatal myocardial infarction, fatal and non-fatal stroke, and other coronary death).

Compared to low leisure time physical activity, after adjustment for age, sex, lifestyle, health, and education, moderate, high, and very high activity were associated with 26%, 41%, and 40% reduced risks of early death, respectively. In contrast, compared to low work activity, high and very high activity were associated with 13% and 27% increased risks of death, respectively.

Similarly, after adjustments, compared to low leisure activity, moderate, high, and very high levels of leisure activity were associated with 14%, 23%, and 15% reduced risks of MACE, respectively. Compared to low work activity, high and very high levels were associated with 15% and 35% increased risks of MACE, respectively.

Professor Holtermann said: "Many people with manual jobs believe they get fit and healthy by their physical activity at work and therefore can relax when they get home. Unfortunately, our results suggest that this is not the case. And while these workers could benefit from leisure physical activity, after walking 10,000 steps while cleaning or standing seven hours in a production line, people tend to feel tired so that's a barrier."

While the study did not investigate the reasons for the opposite associations for occupational and leisure time physical activity, Professor Holtermann said: "A brisk 30-minute walk will benefit your health by raising your heart rate and improving your cardiorespiratory fitness, while work activity often does not sufficiently increase heart rate to improve fitness. In addition, work involving lifting for several hours a day increases blood pressure for many hours, which is linked with heart disease risk, while short bursts of intense physical activity during leisure raises blood pressure only briefly."

Professor Holtermann's vision is to re-organise occupational activity so that it mimics the beneficial aspects of leisure exercise. Several approaches are being piloted, such as rotating between workstations on a production line so that employees do a "healthy mixture" of sitting, standing, and lifting during a shift. In another study, childcare workers play games together with children, instead of observing, so that both get their heart rate up and increase fitness. "We are trying to vary the tasks, give recovery time, or raise heart rate so there is a fitness and health benefit," he said.

Professor Holtermann concluded: "Societies need adults with sufficient health and fitness to work longer since the retirement age is increasing. We need to find ways to make active work good for health."

https://www.sciencedaily.com/releases/2021/04/210408212952.htm

Exercise, healthy diet in midlife may prevent serious health conditions in senior years

March 31, 2021

Science Daily/American Heart Association

Following a routine of regular physical activity combined with a diet including fruits, vegetables and other healthy foods may be key to middle-aged adults achieving optimal cardiometabolic health later in life, according to new research using data from the Framingham Heart Study published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

Cardiometabolic health risk factors include the metabolic syndrome, a cluster of disorders such as excess fat around the waist, insulin resistance and high blood pressure. Presence of the metabolic syndrome may increase the risk of developing heart disease, stroke and Type 2 diabetes.

Researchers noted it has been unclear whether adherence to both the U.S. Department of Health and Human Services' 2018 Physical Activity Guidelines for Americans and their 2015-2020 Dietary Guidelines for Americans -- as opposed to only one of the two -- in midlife confers the most favorable cardiometabolic health outcomes later in life. The physical activity guidelines recommend that adults achieve at least 150 minutes of moderate or 75 minutes of vigorous physical activity per week, such as walking or swimming. The dietary guidelines, which were updated in January 2021, offer suggestions for healthy eating patterns, nutritional targets and dietary limits.

In an analysis of data from participants of the Framingham Heart Study, which began more than 70 years ago in Framingham, Massachusetts, investigators examined data from 2,379 adults ages 18 and older and their adherence to the two guidelines. They observed that meeting a combination of the two recommendations during midlife was associated with lower odds of metabolic syndrome and developing serious health conditions as participants aged in their senior years in 2016-2019 examinations.

"Health care professionals could use these findings to further promote and emphasize to their patients the benefits of a healthy diet and a regular exercise schedule to avoid the development of numerous chronic health conditions in the present and in later life," said corresponding author Vanessa Xanthakis, Ph.D., FAHA, assistant professor of medicine and biostatistics in the Section of Preventive Medicine and Epidemiology at Boston University School of Medicine in Boston. "The earlier people make these lifestyle changes, the more likely they will be to lower their risk of cardiovascular-associated diseases later in life."

Study participants were selected from the third generation of the Framingham Heart Study. Participants (average age 47, 54% women) were examined between 2008 and 2011. Researchers evaluated physical activity using a specialized device known as an omnidirectional accelerometer. The device, which tracks sedentary and physical activity, was worn on the participant's hip for eight days. Researchers also collected dietary information from food frequency questionnaires to measure the kinds and levels of food and nutrients consumed.

In this investigation, researchers observed that among all participants, 28% met recommendations of both the physical activity and dietary guidelines, while 47% achieved the recommendations in only one of the guidelines. Researchers also observed that:

• participants who followed the physical activity recommendations alone had 51% lower odds of metabolic syndrome;

• participants who adhered to the dietary guidelines alone had 33% lower odds; and

• participants who followed both guidelines had 65% lower odds of developing metabolic syndrome.

"It is noteworthy that we observed a dose-response association of adherence to diet and physical activity guidelines with risk of cardiometabolic disease later in life," Xanthakis said. "Participants who met the physical activity guidelines had progressively lower risk of cardiometabolic disease as they increased adherence to the dietary guidelines."

All study participants were white adults, therefore, the findings cannot be generalized to people in other racial or ethnic groups. Additional studies with a multiethnic participant sample are needed, researchers said.

https://www.sciencedaily.com/releases/2021/03/210331085852.htm

Air pollution and physical exercise: When to do more or less

March 29, 2021

Science Daily/European Society of Cardiology

Physical activity is important in preventing heart and blood vessel disease in young people so long as they don't undertake very strenuous activity on days when air pollution levels are high, according to a nationwide study of nearly 1.5 million people published today (Tuesday) in the European Heart Journal.

Until now, little has been known about the trade-offs between the health benefits of physical activity taking place outdoors and the potentially harmful effects of air pollution. Previous research by the authors of the current study had investigated the question in middle-aged people at a single point in time, but this is the first time that it has been investigated in people aged between 20-39 years over a period of several years. In addition, the researchers wanted to see what happens when people increase or decrease their physical activity over time.

The researchers from Seoul National University College of Medicine (South Korea), led by Professor Sang Min Park, looked at information from the National Health Insurance Service (NHIS) in South Korea for 1,469,972 young Koreans living in cities, who underwent two consecutive health examinations during two screening periods: 2009-2010 and 2011-2012. They followed up the participants from January 2013 to December 2018.

At each health check-up the participants completed a questionnaire asking about their physical activity in the past seven days and this information was converted into units of metabolic equivalent task (MET) minutes per week (MET-mins/week). The participants were divided into four groups: 0, 1-499, 500-999 and 1000 or more MET-mins/week. European Society of Cardiology guidelines recommend people should try to do 500-999 MET-mins/week and this can be achieved by, for example, running, cycling or hiking for 15-30 minutes five times a week, or brisk walking, doubles tennis or slow cycling for 30-60 minutes five times a week. [1]

The researchers used data from the National Ambient Air Monitoring System in South Korea to calculate annual average levels of air pollution, in particular the levels of small particulate matter that are less than or equal to 10 or 2.5 microns in diameter, known as PM10 and PM2.5 [2]. The amount of exposure to air pollution was categorised at two levels: low to moderate (less than 49.92 and 26.43 micrograms per cubic metre, μm/m3, for PM10 and PM2.5 respectively), and high (49.92 and 26.46 μm/m3 or more, respectively). [2]

Dr Seong Rae Kim, first author of the paper, said: "We found that in young adults aged 20-39 years old, the risk of cardiovascular diseases, such as stroke and heart attack, increased as the amount of physical activity decreased between the two screening periods in the group with low levels of exposure to air pollution.

"However, in the group with high levels of exposure to air pollution, increasing the amount of physical activity to more than 1000 MET-min/week, which is more than internationally recommended levels for physical activity, could adversely affect cardiovascular health. This is an important result suggesting that, unlike middle-aged people over 40, excessive physical activity may not always be beneficial for cardiovascular health in younger adults when they are exposed to high concentrations of air pollution."

He continued: "Ultimately, it is imperative that air pollution is improved at the national level in order to maximise the health benefits of exercising in young adults. These are people who tend to engage in physical activity more than other age groups while their physical ability is at its best. If air quality is not improved, this could result in the incidence of cardiovascular diseases actually increasing despite the health benefits gained from exercise."

The researchers adjusted their results to take account of factors that could affect them, such as age, sex, household income, body mass index, smoking and alcohol consumption. During the follow-up period there were 8706 cardiovascular events. Among people exposed to high levels of PM2.5 air pollution, those who increased their exercise from 0 to 1000 MET-min/week or more between the two screening periods had a 33% increased risk of cardiovascular disease during the follow-up period compared to those who were physically inactive and did not increase their exercise, although this result was slightly weaker than that needed to achieve statistical significance. This means an extra 108 people per 10,000 might develop cardiovascular disease during the follow-up period.

Among people exposed to low to moderate levels of PM2.5, those who increased their physical activity from none to 1000 MET-min/week or more had a 27% reduced risk of developing cardiovascular disease compared to those who remained inactive, although this result was also not quite statistically significant. This means 49 fewer people per 10,000 might develop cardiovascular disease during the follow-up period.

Dr Kim said: "These results are very close to statistical significance. In fact, a further analysis ... of our paper shows that statistical significance was achieved for increasing and decreasing amounts of physical activity."

For low to moderate levels of PM10 air pollution, there was a statistically significant 38% or 22% increased risk of cardiovascular disease among people who started off doing 1000 MET-min/week or more and then reduced their activity to none or to 1-499 MET min/week, respectively, compared to people who maintained the same high level of activity. These results were statistically significant and mean that 74 and 66 extra people per 10,000 respectively would develop cardiovascular problems during the follow-up period.

Professor Sang Min Park, who led the research, said: "Overall, our results show that physical activity, particularly at the level recommended by European Society of Cardiology guidelines, is associated with a lower risk of developing heart and blood vessel disease among young adults. However, when air pollution levels are high, exercising beyond the recommended amount may offset or even reverse the beneficial effects."

The study cannot show that air pollution causes the increased cardiovascular risk, only that it is associated with it. Other limitations are that there was no information on whether or not the exercise took place indoors or outdoors; participants may not have remembered correctly the amount of exercise they took in the seven days before they attended their screening interview, although this is unlikely; PM2.5 data were only measured in three major cities; and the researchers did not investigate the short-term effects of exposure to air pollution.

https://www.sciencedaily.com/releases/2021/03/210329200307.htm

Activity is good: Varied activity is better

March 29, 2021

Science Daily/University of Basel

The recommendations are clear: physical activity is good for mental health. But it also depends on how varied it is. That's what a new study by researchers at the University of Basel shows, pointing to one of the reasons why well-being suffers during the pandemic.

A walk in the morning, a jog in the evening or even just going out to buy groceries: activity helps the psyche. Many are trying to stay active during the pandemic despite mandatory home office and limited leisure activities. Others find that they are moving significantly less than before the pandemic because previous everyday activities are off-limits due to measures taken against the spread of Covid-19.

Against this backdrop, a study led by Professor Andrew Gloster of the University of Basel provides an indication of what impact restricted movement patterns might have. The results have been published in the journal BMC Psychiatry.

That exercise promotes not only physical but also mental health is known from various studies. However, these mostly focused on the influence of deliberate exercise programs. "In contrast, little was known about whether everyday, naturally chosen movement patterns also influence mental health," Gloster explains.

To investigate this, he and researchers at the University Psychiatric Clinics in Basel collected GPS data from 106 patients with mental disorders who agreed to participate. For this purpose, the study participants were given extra smartphones that they carried with them for a week. This allowed the researchers to track their movements without interfering with the patients' daily routine. The research team then compared the movement data with surveys of the participants' well-being and symptoms of their mental illness.

The results showed that the more people moved and the more varied their movements, the greater their sense of well-being. However, no influence on the symptoms could be determined. "Our results suggest that activity alone is not enough to reduce symptoms of mental disorders, but can at least improve subjective well-being," Gloster elaborates.

"Although the data were collected before the pandemic, the results are also relevant in light of the limitations during the coronavirus crisis," he adds. Because many social and recreational activities were discontinued during that time, many people's physical activity patterns also likely became more monotonous. Various studies by research groups at the University of Basel have been able to show that the pandemic took a toll on the psyche of the population. The results of the team led by Gloster suggest that the restricted movement patterns could also play a role in this.

https://www.sciencedaily.com/releases/2021/03/210329122450.htm

More protein doesn't mean more strength in resistance-trained middle-aged adults

March 25, 2021

Science Daily/University of Illinois at Urbana-Champaign, News Bureau

A 10-week muscle-building and dietary program involving 50 middle-aged adults found no evidence that eating a high-protein diet increased strength or muscle mass more than consuming a moderate amount of protein while training. The intervention involved a standard strength-training protocol with sessions three times per week. None of the participants had previous weightlifting experience.

Published in the American Journal of Physiology: Endocrinology and Metabolism, the study is one of the most comprehensive investigations of the health effects of diet and resistance training in middle-aged adults, the researchers say. Participants were 40-64 years of age.

The team assessed participants' strength, lean-body mass, blood pressure, glucose tolerance and several other health measures before and after the program. They randomized participants into moderate- and high-protein diet groups. To standardize protein intake, the researchers fed each person a freshly cooked, minced beef steak and carbohydrate beverage after every training session. They also sent participants home with an isolated-protein drink to be consumed every evening throughout the 10 weeks of the study.

"The moderate-protein group consumed about 1.2 grams of protein per kilogram of body weight per day, and the high-protein group consumed roughly 1.6 grams per kilogram per day," said Colleen McKenna, a graduate student in the division of nutritional sciences and registered dietician at the University of Illinois Urbana-Champaign who led the study with U. of I. kinesiology and community health professor Nicholas Burd. The team kept calories equivalent in the meals provided to the two groups with additions of beef tallow and dextrose.

The study subjects kept food diaries and McKenna counseled them every other week about their eating habits and protein intake.

In an effort led by U. of I. food science and human nutrition professor Hannah Holscher, the team also analyzed gut microbes in fecal samples collected at the beginning of the intervention, after the first week -- during which participants adjusted to the new diet but did not engage in physical training -- and at the end of the 10 weeks. Previous studies have found that diet alone or endurance exercise alone can alter the composition of microbes in the digestive tract.

"The public health messaging has been that Americans need more protein in their diet, and this extra protein is supposed to help our muscles grow bigger and stronger," Burd said. "Middle age is a bit unique in that as we get older, we lose muscle and, by default, we lose strength. We want to learn how to maximize strength so that as we get older, we're better protected and can ultimately remain active in family and community life."

The American Food and Nutrition Board recommends that adults get 0.8 grams of protein per kilogram of body weight per day to avoid developing a protein deficiency. The team tried to limit protein consumption in the moderate-protein group to the Recommended Daily Allowance, but their food diaries revealed those participants were consuming, on average, 1.1 to 1.2 grams of protein per kilogram of body weight per day. Those in the high-protein group ate about 1.6 grams of protein per kilogram per day -- twice the recommended amount.

Burd and his colleagues hypothesized that getting one's protein from a high-quality source like beef and consuming significantly more protein than the RDA would aid in muscle growth and strength in middle-aged adults engaged in resistance training. But at the end of the 10 weeks, the team saw no significant differences between the groups. Their gains in strength, their body fat, lean body mass, glucose tolerance, kidney function, bone density and other "biomarkers" of health were roughly the same.

The only potentially negative change researchers recorded between the groups involved alterations to the population of microbes that inhabit the gut. After one week on the diet, those in the high-protein group saw changes in the abundance of some gut microbes that previous studies have linked to negative health outcomes. Burd and his colleagues found that their strength-training intervention reversed some of these changes, increasing beneficial microbes and reducing the abundance of potentially harmful ones.

"We found that high protein intake does not further increase gains in strength or affect body composition," Burd said. "It didn't increase lean mass more than eating a moderate amount of protein. We didn't see more fat loss, and body composition was the same between the groups. They got the gain in weight, but that weight gain was namely from lean-body-mass gain."

Burd said the finding makes him question the push to increase protein intake beyond 0.8-1.1 grams per kilogram of body weight, at least in middle-aged weightlifters consuming high-quality animal-based protein on a regular basis.

McKenna said the team's multidisciplinary approach and in-depth tracking of participants' dietary habits outside the laboratory makes it easier to understand the findings and apply them to daily life.

"We have recommendations for healthy eating and we have recommendations for how you should exercise, but very little research looks at how the two together impact our health," she said. The study team included exercise physiologists, registered dietitians and experts on gut microbiology.

"This allowed us to address every aspect of the intervention in the way it should be addressed," McKenna said. "We're honoring the complexity of human health with the complexity of our research."

https://www.sciencedaily.com/releases/2021/03/210325101256.htm

Exercise boosts blood flow to the brain

The results add to growing evidence that exercise programs may help older adults slow the onset of memory loss and dementia

March 23, 2021

Science Daily/UT Southwestern Medical Center

It's not just your legs and heart that get a workout when you walk briskly; exercise affects your brain as well. A new study by researchers at UT Southwestern shows that when older adults with mild memory loss followed an exercise program for a year, the blood flow to their brains increased. The results were published online today in the Journal of Alzheimer's Disease.

"This is part of a growing body of evidence linking exercise with brain health," says study leader Rong Zhang, Ph.D., professor of neurology at UTSW. "We've shown for the first time in a randomized trial in these older adults that exercise gets more blood flowing to your brain."

As many as one-fifth of people age 65 and older have some level of mild cognitive impairment (MCI) -- slight changes to the brain that affect memory, decision-making, or reasoning skills. In many cases, MCI progresses to dementia, including Alzheimer's disease.

Scientists have previously shown that lower-than-usual levels of blood flow to the brain, and stiffer blood vessels leading to the brain, are associated with MCI and dementia. Studies have also suggested that regular aerobic exercise may help improve cognition and memory in healthy older adults. However, scientists have not established whether there is a direct link between exercise, stiffer blood vessels, and brain blood flow.

"There is still a lot we don't know about the effects of exercise on cognitive decline later in life," says C. Munro Cullum, Ph.D., professor of psychiatry at UTSW and co-senior author of the study. "MCI and dementia are likely to be influenced by a complex interplay of many factors, and we think that, at least for some people, exercise is one of those factors."

In the study, Zhang, Cullum, and their colleagues followed 70 men and women aged 55 to 80 who had been diagnosed with MCI. Participants underwent cognitive exams, fitness tests, and brain magnetic resonance imaging (MRI) scans. Then they were randomly assigned to either follow a moderate aerobic exercise program or a stretching program for one year. The exercise program involved three to five exercise sessions a week, each with 30-40 minutes of moderate exercise such as a brisk walk.

In both programs, exercise physiologists supervised participants for the first four to six weeks, then had the patients record their exercises and wear a heart rate monitor during exercise.

Forty-eight study participants -- 29 in the stretching group and 19 in the aerobic exercise group -- completed the full year of training and returned for follow-up tests. Among them, those who performed aerobic exercise showed decreased stiffness of blood vessels in their neck and increased overall blood flow to the brain. The more their oxygen consumption (one marker of aerobic fitness) increased, the greater the changes to the blood vessel stiffness and brain blood flow. Changes in these measurements were not found among people who followed the stretching program.

While the study didn't find any significant changes in memory or other cognitive function, the researchers say that may be because of the small size or short length of the trial. Changes to blood flow could precede changes to cognition, they say. They're already carrying out a larger two-year study, Risk Reduction for Alzheimer's Disease (rrAD), that further investigates the link between exercise and cognitive decline.

"There are likely some people who benefit more from exercise than others," says Cullum. "But with the sample size in this study, it was hard to analyze subgroups of people to make those conclusions."

Still, the data are important to help explain the effects of exercise on the brain and why it can be beneficial, say Zhang and Cullum, who are members of the Peter O'Donnell Jr. Brain Institute.

"Having physiological findings like this can also be useful for physicians when they talk to their patients about the benefits of exercise," says Zhang. "We now know, based on a randomized, controlled trial, that exercise can increase blood flow to the brain, which is a good thing."

https://www.sciencedaily.com/releases/2021/03/210323131213.htm

A strong coffee half an hour before exercising increases fat-burning

Drinking a strong coffee half an hour before exercising increases fat-burning

March 22, 2021

Science Daily/University of Granada

Scientists from the Department of Physiology of the University of Granada (UGR) have shown that caffeine (about 3 mg/kg, the equivalent of a strong coffee) ingested half an hour before aerobic exercise significantly increases the rate of fat-burning. They also found that if the exercise is performed in the afternoon, the effects of the caffeine are more marked than in the morning.

In their study, published in the Journal of the International Society of Sports Nutrition, the researchers aimed to determine whether caffeine -- one of the most commonly-consumed ergogenic substances in the world to improve sports performance -- actually does increase oxidation or "burning" of fat during exercise. Despite the fact that its consumption in the form of supplements is very common, the scientific evidence for its beneficial claims is scarce.

"The recommendation to exercise on an empty stomach in the morning to increase fat oxidation is commonplace. However, this recommendation may be lacking a scientific basis, as it is unknown whether this increase is due to exercising in the morning or due to going without food for a longer period of time," explains the lead author of this research, Francisco José Amaro-Gahete of the UGR's Department of Physiology.

A total of 15 men (mean age, 32) participated in the research, completing an exercise test four times at seven-day intervals. Subjects ingested 3 mg/kg of caffeine or a placebo at 8am and 5pm (each subject completed the tests in all four conditions in a random order). The conditions prior to each exercise test (hours elapsed since last meal, physical exercise, or consumption of stimulant substances) were strictly standardized, and fat oxidation during exercise was calculated accordingly.

Maximum fat oxidation 

"The results of our study showed that acute caffeine ingestion 30 minutes before performing an aerobic exercise test increased maximum fat oxidation during exercise regardless of the time of day," explains Francisco J. Amaro. The existence of a diurnal variation in fat oxidation during exercise was confirmed, the values being higher in the afternoon than in the morning for equal hours of fasting.

These results also show that caffeine increases fat oxidation during morning exercise in a similar way to that observed without caffeine intake in the afternoon.

In summary, the findings of this study suggest that the combination of acute caffeine intake and aerobic exercise performed at moderate intensity in the afternoon provides the optimal scenario for people seeking to increase fat-burning during physical exercise.

https://www.sciencedaily.com/releases/2021/03/210322175042.htm

Cells burn more calories after just one bout of moderate aerobic exercise

March 22, 2021

Science Daily/Oregon State University

In a recent study testing the effects of exercise on overall metabolism, researchers at Oregon State University found that even a single session of moderate aerobic exercise makes a difference in the cells of otherwise sedentary people.

Mitochondria are the part of the cell responsible for the biological process of respiration, which turns fuels such as sugars and fats into energy, so the researchers focused only on mitochondria function.

"What we found is that, regardless of what fuel the mitochondria were using, there were mild increases in the ability to burn off the fuels," said Matt Robinson, lead author on the study and an assistant professor in the College of Public Health and Human Sciences.

OSU researchers recruited participants who do not follow a regular exercise routine and had them ride a stationary bike for an hour at a moderate intensity. They biopsied their muscles 15 minutes later to test how efficient the mitochondria were after the exercise was completed and compared those results with a resting day.

Post-exercise, study participants' mitochondria burned 12-13% more fat-based fuel and 14-17% more sugar-based fuel. While the effects were not drastic, they were consistent, Robinson said.

"It's pretty remarkable that even after just one hour of exercise, these people were able to burn off a little more fuel," he said.

Previous research in the field has long established that regular exercise creates lasting change in people's metabolism, making their bodies burn more energy even when they're not working out.

Prior studies have looked at highly trained or athletic people, but Robinson's team wanted to look specifically at singular bouts of exercise in people who were generally active and disease-free but who did not have structured exercise regimes. These people were on the lower end of fitness, which is associated with low mitochondrial abundance and energy production. Participants were monitored while working out at approximately 65% of their maximal effort, where they could keep up the cycling pace for an hour or more and still comfortably carry on a conversation.

Robinson said they're hoping these results help break down the mental barrier of people thinking they need to be elite athletes for exercise to make an impact on their health.

"From a big picture health perspective, it's very encouraging for people to realize that you can get health benefits from a single session of exercise," Robinson said. "We're trying to encourage people, 'You did one, why don't you try to do two? Let's do three.'

"We know that exercise is good for you, in general. But those benefits of that single bout of exercise seem to fade away after a day or two. You get the long-term benefits when you do that exercise again and again and you make it a regular habit."

In this study, Robinson's research team focused narrowly on mitochondria to find out how big a role mitochondria play in the overall function of muscle metabolism. Other studies are looking at changes in blood flow to the muscle and how the muscle metabolizes fats versus sugars.

From a disease perspective, Robinson said it's clear that obesity and diabetes involve impairments in metabolism. Physiologically, when the body undergoes exercise, sugars tend to be burned off first while fats are stored, but in cases of diabetes and obesity, there is some dysregulation in metabolism that causes the body to not be able to switch between the two types of fuel.

Exercise can help reset that system, he said.

"Since those get burned off in the mitochondria, our hope is that with exercise, we could increase the mitochondria and then improve how the body burns off fats and sugars," he said.

https://www.sciencedaily.com/releases/2021/03/210322085520.htm

Aluminum is intricately associated with the neuropathology of familial Alzheimer's disease

April 9, 2021

Science Daily/IOS Press

A new study published in the Journal of Alzheimer's Disease Reports continues to support a growing body of evidence that aluminum contributes to the pathogenesis of Alzheimer's disease (AD). Researchers found aluminum co-located with phosphorylated tau protein, which is an early initiator of AD. This study builds upon two earlier published studies (including Mold et al., 2020, Journal of Alzheimer's Disease) from the same group. 

The new data demonstrate that aluminum is co-located with phosphorylated tau protein, present as tangles within neurons in the brains of early-onset or familial Alzheimer's disease. "The presence of these tangles is associated with neuronal cell death, and observations of aluminum in these tangles may highlight a role for aluminum in their formation," explained lead investigator Matthew John Mold, PhD, Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK.

The earlier research highlighted widespread co-localization of aluminum and amyloid-β in brain tissue in familial AD. The researchers used a highly-selective method of immunolabelling in the current study, combined with aluminum-specific fluorescence microscopy. Phosphorylated tau in tangles co-located with aluminum in the brain tissue of the same cohort of Colombian donors with familial AD were identified. "It is of interest and perhaps significance with respect to aluminum's role in AD that its unequivocal association with tau is not as easily recognizable as with amyloid-β. There are many more aggregates of aluminum with amyloid-β than with tau in these tissues and the latter are predominantly intracellular," remarked co-author, Professor Christopher Exley.

George Perry, PhD, Editor-in-Chief of the Journal of Alzheimer's Disease, comments: "Aluminum accumulation has been associated with Alzheimer's disease for nearly half a century, but it is the meticulously specific studies of Drs. Mold and Exley that are defining the exact molecular interaction of aluminum and other multivalent metals that may be critical to formation of the pathology of Alzheimer's disease."

"The new data may suggest that the association of aluminum with extracellular senile plaques precedes that with intracellular aggregates of tau. These relationships with both amyloid-β and tau may account for the high levels of aluminum observed in the brain tissue of donors with familial AD versus those without a diagnosis of neurodegenerative disease," said Dr. Mold. "Tau and amyloid-beta are known to act in synergy to produce neurotoxicity in AD and our data provide new evidence for a role of aluminum in this process."

https://www.sciencedaily.com/releases/2021/04/210409124748.htm

Fighting dementia with play

April 9, 2021

Science Daily/ETH Zurich

A dementia diagnosis turns the world upside down, not only for the person affected but also for their relatives, as brain function gradually declines. Those affected lose their ability to plan, remember things or behave appropriately. At the same time, their motor skills also deteriorate. Ultimately, dementia patients are no longer able to handle daily life alone and need comprehensive care. In Switzerland alone, more than 150,000 people share this fate, and each year a further 30,000 new cases are diagnosed.

To date, all attempts to find a drug to cure this disease have failed. Dementia, including Alzheimer's -- the most common of several forms of dementia -- remains incurable. However, a clinical study carried out in Belgium with the involvement of ETH researcher Eling de Bruin has now shown for the first time that cognitive motor training improves both the cognitive and physical skills of significantly impaired dementia patients. A fitness game, known as "Exergame," developed by the ETH spin-off Dividat was used in the study.

Better cognitive ability thanks to training

In 2015, a team of scientists led by ETH researcher Patrick Eggenberger showed that older people who train both body and mind simultaneously demonstrate better cognitive performance and can thereby also prevent cognitive impairment (as reported by ETH News). However, this study was carried out on healthy subjects only.

"It has been suspected for some time that physical and cognitive training also have a positive effect on dementia," explains de Bruin, who worked with Eggenberger at the Institute of Human Movement Sciences and Sport at ETH Zurich. "However, in the past it has been difficult to motivate dementia patients to undertake physical activity over extended periods."

ETH spin-off combines exercise and fun

With a view to changing this, Eva van het Reve, a former ETH doctoral student, founded the ETH spin-off Dividat in 2013 together with her PhD supervisor Eling de Bruin and another doctoral student. "We wanted to devise a customised training programme that would improve the lives of older people," says van het Reve. Fun exercises were developed in order to encourage people who were already experiencing physical and cognitive impairments to participate in training, and the Senso training platform was born.

The platform consists of a screen with the game software and a floor panel with four fields that measure steps, weight displacement and balance. The users attempt to complete a sequence of movements with their feet as indicated on the screen, enabling them to train both physical movement and cognitive function simultaneously. The fact that the fitness game is also fun makes it easier to motivate the subjects to practice regularly.

Eight weeks' training for dementia patients

An international team led by Nathalie Swinnen, a doctoral student at KU Leuven, and co-supervised by ETH researcher de Bruin, recruited 45 subjects for the study. The subjects were residents of two Belgian care homes, aged 85 years on average at the time of the study and all with severe dementia symptoms.

"The participants were divided into two groups on a random basis," explains de Bruin. "The first group trained for 15 minutes with the Dividat Senso three times a week for eight weeks, while the second group listened to and watched music videos of their choice." Following the eight-week training programme, the physical, cognitive and mental capacity of all subjects was measured in comparison with the start of the study.

Regular play has an effect

The results offer hope to dementia patients and their relatives: training with this machine indeed enhanced cognitive skills, such as attention, concentration, memory and orientation. "For the first time, there's hope that through targeted play we will be able not only to delay but also weaken the symptoms of dementia," emphasises de Bruin.

It is particularly striking that the control group deteriorated further over the eight-week period, while significant improvements were recorded in the training group. "These highly encouraging results are in line with the expectation that dementia patients are more likely to deteriorate without training," adds de Bruin.

But playful training not only has a positive impact on cognitive ability -- researchers were also able to measure positive effects on physical capability, such as reaction time. After just eight weeks, the subjects in the training group reacted significantly more quickly, while the control group deteriorated. This is encouraging in that the speed with which older people respond to impulses is critical in determining whether they can to avoid a fall.

A better understanding of brain processes

The research group led by de Bruin is currently working on replicating the results of this pilot study with people with mild cognitive impairment -- a precursor of dementia. The aim is to use MRI scans to investigate more closely the neural processes in the brain responsible for the cognitive and physical improvement.

https://www.sciencedaily.com/releases/2021/04/210409093607.htm

Women accumulate Alzheimer's-related protein faster

March 25, 2021

Science Daily/Lund University

Alzheimer's disease seems to progress faster in women than in men. The protein tau accumulates at a higher rate in women, according to research from Lund University in Sweden. The study was recently published in Brain.

Over 30 million people suffer from Alzheimer's disease worldwide, making it the most common form of dementia. Tau and beta-amyloid are two proteins known to aggregate and accumulate in the brain in patients with Alzheimer's.

The first protein to aggregate in Alzheimer's is beta-amyloid. Men and women are equally affected by the first disease stages, and the analysis did not show any differences in the accumulation of beta-amyloid. Memory dysfunction arises later, when tau starts to accumulate. More women than men are affected by memory problems due to Alzheimer's, and it was for tau that the researchers found a higher rate of accumulation in women.

"Tau accumulation rates vary greatly between individuals of the same sex, but in the temporal lobe, which is affected in Alzheimer's disease, we found a 75% higher accumulation rate in women as a group compared to men," explains Ruben Smith, first author of the study.

The accumulation of tau is faster in patients who already have a pathological accumulation of beta-amyloid, and are in the early phase of the disease. The discovery that the accumulation rate of tau is higher in women remained even after adjusting for age and the levels of tau they had at the beginning. Together with data from three similar cohorts in the USA, the project contains 209 women and 210 men.

"The next step would be to examine why this accumulation is faster in women," says Sebastian Palmqvist, the researcher responsible for the cognitive assessment of the patients.

The study did not investigate the reasons for the higher rate of tau accumulation in women.

"Our study strongly indicates that the faster spread of tau makes women more prone to develop dementia because of Alzheimer's pathology compared to men. Future experimental studies will be important to understand the reasons behind this," concludes Professor Oskar Hansson.

https://www.sciencedaily.com/releases/2021/03/210325115423.htm

Eating processed meat could increase dementia risk

March 21, 2021

Science Daily/University of Leeds

Scientists from the University's Nutritional Epidemiology Group used data from 500,000 people, discovering that consuming a 25g serving of processed meat a day, the equivalent to one rasher of bacon, is associated with a 44% increased risk of developing the disease.

But their findings also show eating some unprocessed red meat, such as beef, pork or veal, could be protective, as people who consumed 50g a day were 19% less likely to develop dementia. 

The researchers were exploring whether there is a link between consumption of meat and development of dementia, a health condition which affects 5%-8% of over 60s worldwide.

Their results, titled Meat consumption and risk of incident dementia: cohort study of 493,888 UK Biobank participants, are published today in the American Journal of Clinical Nutrition.

Lead researcher Huifeng Zhang, a PhD student from Leeds' School of Food Science and Nutrition, said: "Worldwide, the prevalence of dementia is increasing and diet as a modifiable factor could play a role.

"Our research adds to the growing body of evidence linking processed meat consumption to increased risk of a range of non-transmissible diseases." 

The research was supervised by Professors Janet Cade and Laura Hardie, both at Leeds.

The team studied data provided by UK Biobank, a database containing in-depth genetic and health information from half a million UK participants aged 40 to 69, to investigate associations between consuming different types of meat and risk of developing dementia.  

The data included how often participants consumed different kinds of meat, with six options from never to once or more daily, collected in 2006-2010 by the UK Biobank. The study did not specifically assess the impact of a vegetarian or vegan diet on dementia risk, but it included data from people who said they did not eat red meat. 

Among the participants, 2,896 cases of dementia emerged over an average of eight years of follow up. These people were generally older, more economically deprived, less educated, more likely to smoke, less physically active, more likely to have stroke history and family dementia history, and more likely to be carriers of a gene which is highly associated with dementia. More men than women were diagnosed with dementia in the study population.  

Some people were three to six times more likely to develop dementia due to well established genetic factors, but the findings suggest the risks from eating processed meat were the same whether or not a person was genetically predisposed to developing the disease. 

Those who consumed higher amounts of processed meat were more likely to be male, less educated, smokers, overweight or obese, had lower intakes of vegetables and fruits, and had higher intakes of energy, protein, and fat (including saturated fat). 

Meat consumption has previously been associated with dementia risk, but this is believed to be the first large-scale study of participants over time to examine a link between specific meat types and amounts, and the risk of developing the disease. 

There are around 50 million dementia cases globally, with around 10 million new cases diagnosed every year. Alzheimer's Disease makes up 50% to 70% of cases, and vascular dementia around 25%. Its development and progression are associated with both genetic and environmental factors, including diet and lifestyle.  

Ms Zhang said: "Further confirmation is needed, but the direction of effect is linked to current healthy eating guidelines suggesting lower intakes of unprocessed red meat could be beneficial for health."

Professor Cade said: "Anything we can do to explore potential risk factors for dementia may help us to reduce rates of this debilitating condition. This analysis is a first step towards understanding whether what we eat could influence that risk."

https://www.sciencedaily.com/releases/2021/03/210321215434.htm

CBD reduces plaque, improves cognition in model of familial Alzheimer's

March 9, 2021

Science Daily/Medical College of Georgia at Augusta University

A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer's disease, and improves cognition in an experimental model of early onset familial Alzheimer's, investigators report.

The proteins TREM2 and IL-33 are important to the ability of the brain's immune cells to literally consume dead cells and other debris like the beta-amyloid plaque that piles up in patients' brains, and levels of both are decreased in Alzheimer's.

The investigators report for the first time that CBD normalizes levels and function, improving cognition as it also reduces levels of the immune protein IL-6, which is associated with the high inflammation levels found in Alzheimer's, says Dr. Babak Baban, immunologist and associate dean for research in the Dental College of Georgia and the study's corresponding author.

There is a dire need for novel therapies to improve outcomes for patients with this condition, which is considered one of the fastest-growing health threats in the United States, DCG and Medical College of Georgia investigators write in the Journal of Alzheimer's Disease.

"Right now we have two classes of drugs to treat Alzheimer's," says Dr. John Morgan, neurologist and director of the Movement and Memory Disorder Programs in the MCG Department of Neurology. One class increases levels of the neurotransmitter acetylcholine, which also are decreased in Alzheimer's, and another works through the NMDA receptors involved in communication between neurons and important to memory. "But we have nothing that gets to the pathophysiology of the disease," says Morgan, a study coauthor.

The DCG and MCG investigators decided to look at CBD's ability to address some of the key brain systems that go awry in Alzheimer's.

They found CBD appears to normalize levels of IL-33, a protein whose highest expression in humans is normally in the brain, where it helps sound the alarm that there is an invader like the beta-amyloid accumulation. There is emerging evidence of its role as a regulatory protein as well, whose function of either turning up or down the immune response depends on the environment, Baban says. In Alzheimer's, that includes turning down inflammation and trying to restore balance to the immune system, he says.

That up and down expression in health and disease could make IL-33 both a good biomarker and treatment target for disease, the investigators say.

CBD also improved expression of triggering receptor expressed on myeloid cells 2, or TREM2, which is found on the cell surface where it combines with another protein to transmit signals that activate cells, including immune cells. In the brain, its expression is on the microglial cells, a special population of immune cells found only in the brain where they are key to eliminating invaders like a virus and irrevocably damaged neurons.

Low levels of TREM2 and rare variations in TREM2 are associated with Alzheimer's, and in their mouse model TREM2 and IL-33 were both low.

Both are essential to a natural, ongoing housekeeping process in the brain called phagocytosis, in which microglial cells regularly consume beta amyloid, which is regularly produced in the brain, the result of the breakdown of amyloid-beta precursor protein, which is important to the synapses, or connection points, between neurons, and which the plaque interrupts.

They found CBD treatment increased levels of IL-33 and TREM2 -- sevenfold and tenfold respectively.

CBD's impact on brain function in the mouse model of early onset Alzheimer's was assessed by methods like the ability to differentiate between a familiar item and a new one, as well as observing the rodents' movement.

People with Alzheimer's may experience movement problems like stiffness and an impaired gait, says Dr. Hesam Khodadadi, a graduate student working in Baban's lab. Mice with the disease run in an endless tight circle, behavior which stopped with CBD treatment, says Khodadadi, the study's first author.

Next steps include determining optimal doses and giving CBD earlier in the disease process. The compound was given in the late stages for the published study, and now the investigators are using it at the first signs of cognitive decline, Khodadadi says. They also are exploring delivery systems including the use of an inhaler that should help deliver the CBD more directly to the brain. For the published studies, CBD was put into the belly of the mice every other day for two weeks.

A company has developed both animal and human inhalers for the investigators who also have been exploring CBD's effect on adult respiratory distress syndrome, or ARDS, a buildup of fluid in the lungs that is a major and deadly complication of COVID-19, as well as other serious illnesses like sepsis and major trauma. The CBD doses used for the Alzheimer's study were the same the investigators successfully used to reduce the "cytokine storm" of ARDS, which can irrevocably damage the lungs.

Familial disease is an inherited version of Alzheimer's in which symptoms typically surface in the 30s and 40s and occurs in about 10-15% of patients.

CBD should be at least equally effective in the more common, nonfamilial type Alzheimer's, which likely have more targets for CBD, Baban notes. They already are looking at its potential in a model of this more common type and moving forward to establish a clinical trial.

Plaques as well as neurofibrillary tangles, a collection of the protein tau inside neurons, are the main components of Alzheimer's, Morgan says. Beta-amyloid generally appears in the brain 15-20 years or more before dementia, he says, and the appearance of tau tangles, which can occur up to 10 years afterward, correlates with the onset of dementia. There is some interplay between beta amyloid and tau that decrease the dysfunction of each, Morgan notes.

The Food and Drug Administration is scheduled to make a ruling by early June on a new drug aducanumab, which would be the first to attack and help clear beta amyloid, Morgan says.

https://www.sciencedaily.com/releases/2021/03/210309192548.htm

Head injury 25 years later: Study finds increased risk of dementia

March 9, 2021

Science Daily/University of Pennsylvania School of Medicine

Head injury in the United States is common, with over 23 million adults age 40 or older reporting a history of head injury with loss of consciousness. Many head injuries can be caused by a host of different situations -- from car and motorcycle accidents to sports injuries. What's more, it has become increasingly recognized that the effects from head injuries are long-lasting. New research led by the Perelman School of Medicine at the University of Pennsylvania shows that a single head injury could lead to dementia later in life. This risk further increases as the number of head injuries sustained by an individual increases. The findings also suggest stronger associations of head injury with risk of dementia among women compared to among men and among white as compared to among Black populations.

The researchers, whose findings were published today in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, conducted the investigation using data from the Atherosclerosis Risk in Communities (ARIC) Study, which aimed to uncover associations between head injury and dementia over the span of 25 years in a diverse population in the United States. Previously, data on traumatic brain injury has been limited to select populations, such as military and medical claims databases. These are among the first findings to specifically investigate head injury and dementia risk in both Black and white populations, as well as among both males and females, in a community-based setting.

"Head injury is a significant risk factor for dementia, but it's one that can be prevented. Our findings show that the number of head injuries matter -- more head injuries are associated with greater risk for dementia," said lead investigator, Andrea L.C. Schneider, MD, PhD, an assistant professor of Neurology at Penn. "The dose-dependence of this association suggests that prevention of head injury could mitigate some risk of dementia later in life. While head injury is not the only risk factor for dementia, it is one risk factor for dementia that is modifiable by behavior changes such as wearing helmets and seat belts."

The findings show that compared to participants who never experienced a head injury, a history of a single prior head injury was associated with a 1.25 times increased risk of dementia, and a history of two or more prior head injuries was associated with over 2 times increased risk of dementia compared to individuals without a history of head injury. Overall, 9.5 percent of all dementia cases in the study population could be attributed to at least one prior head injury.

To illustrate the relationship between dementia and head injuries, the authors gathered data from a diverse cohort with a mean baseline age of 54 years, comprised of 56 percent female and 27 percent Black participants from four different communities across the United States. Participants were followed for a median of 25 years through up to six in-person visits and semi-annual telephone follow-ups. Data on head injuries of participants was drawn from hospital records, as well as self-reporting from some participants.

Previous research on dementia and traumatic brain injuries suggests that women are at higher risk for dementia compared to men. Additionally, Black populations overall are at higher risk for dementia compared to people who are white. However, few prior studies have evaluated for possible differences in associations of head injury with dementia risk by sex and race.

This data from the ARIC study found evidence that females were more likely to experience dementia as a result of head injury than males. Further, the study showed that although there is increased dementia risk associated with head injury among both White and Black participants, White participants were at higher risk for dementia after head injury compared to Black participants. The authors conclude that more research is needed to better understand reasons for these observed sex and race differences in the association of head injury with dementia risk.

"Given the strong association of head injury with dementia, there is an important need for future research focused on prevention and intervention strategies aimed at reducing dementia after head injury," Schneider said. "The results of this study have already led to several ongoing research projects, including efforts to uncover the causes of head injury-related dementia as well as investigations into reasons underlying the observed sex and race differences in the risk of dementia associated with head injury."

https://www.sciencedaily.com/releases/2021/03/210309091257.htm

Why odors trigger powerful memories

Smell travels on superhighway to hippocampus in the brain

March 8, 2021

Science Daily/Northwestern University

A new Northwestern Medicine paper is the first to identify a neural basis for how the brain enables odors to so powerfully elicit those memories. The paper shows unique connectivity between the hippocampus -- the seat of memory in the brain -- and olfactory areas in humans.

This new research suggests a neurobiological basis for privileged access by olfaction to memory areas in the brain. The study compares connections between primary sensory areas -- including visual, auditory, touch and smell -- and the hippocampus. It found olfaction has the strongest connectivity. It's like a superhighway from smell to the hippocampus.

"During evolution, humans experienced a profound expansion of the neocortex that re-organized access to memory networks," said lead investigator Christina Zelano, assistant professor of neurology at Northwestern University Feinberg School of Medicine. "Vision, hearing and touch all re-routed in the brain as the neocortex expanded, connecting with the hippocampus through an intermediary -- association cortex -- rather than directly. Our data suggests olfaction did not undergo this re-routing, and instead retained direct access to the hippocampus."

The paper, "Human hippocampal connectivity is stronger in olfaction than other sensory systems" was published March 4 in the journal Progress in Neurobiology.

Epidemic loss of smell in COVID-19 makes research more urgent In COVID-19, smell loss has become epidemic, and understanding the way odors affect our brains -- memories, cognition and more -- is more important than ever, Zelano noted.

"There is an urgent need to better understand the olfactory system in order to better understand the reason for COVID-related smell loss, diagnose the severity of the loss and to develop treatments," said first author Guangyu Zhou, research assistant professor of neurology at Northwestern. "Our study is an example of the basic research science that our understanding of smell, smell loss and future treatments is built on."

Below is a Q & A with Zelano about the importance of the sense of smell, olfactory research and the link to COVID-19.

Why do smells evoke such vivid memories? 

"This has been an enduring mystery of human experience. Nearly everyone has been transported by a whiff of an odor to another time and place, an experience that sights or sounds rarely evoke. Yet, we haven't known why. The study found the offactory parts of the brain connect more strongly to the memory parts than other senses. This is a major piece of the puzzle, a striking finding in humans. We believe our results will help future research solve this mystery.'

How does smell research relate to COVID-19?

"The COVID-19 epidemic has brought a renewed focus and urgency to olfactory research. While our study doesn't address COVID smell loss directly, it does speak to an important aspect of why olfaction is important to our lives: smells are a profound part of memory, and odors connect us to especially important memories in our lives, often connected to loved ones. The smell of fresh chopped parsley may evoke a grandmother's cooking, or a whiff of a cigar may evoke a grandfather's presence. Odors connect us to important memories that transport us back to the presence of those people."

Loss of smell linked to depression and poor quality of life

"Loss of the sense of smell is underestimated in its impact. It has profound negative effects of quality of life, and many people underestimate that until they experience it. Smell loss is highly correlated with depression and poor quality of life.

"Most people who lose their smell to COVID regain it, but the time frame varies widely, and some have had what appears to be permanent loss. Understanding smell loss, in turn, requires research into the basic neural operations of this under-studied sensory system.

"Research like ours moves understanding of the olfactory parts of the brain forward, with the goal of providing the foundation for translational work on, ultimately, interventions."

https://www.sciencedaily.com/releases/2021/03/210308140743.htm

A weak heart makes a suffering brain

Evidence of disturbed gene activity in the brain as a result of heart problems

February 26, 2021

Science Daily/DZNE - German Center for Neurodegenerative Diseases

Heart problems cause disturbed gene activity in the brain's memory center, from which cognitive deficits arise. Researchers at the German Center for Neurodegenerative Diseases (DZNE), the University Medical Center Göttingen (UMG) and the German Center for Cardiovascular Research (DZHK) come to this conclusion based on laboratory studies. They consider that they have found a possible cause for the increased risk of dementia in people with heart problems. In mice, a specific drug which is known to affect gene activity alleviated the mental deficits. The involved experts see these results as potential approaches for therapies. The study data are published in the scientific journal EMBO Molecular Medicine.

In Germany, about four million people are affected by what is called "heart failure": Their heart muscle is too weak to pump enough blood through the body and is therefore abnormally enlarged. Physical fitness and quality of life suffer as a result. Moreover, affected individuals have an increased risk of developing dementia. "People with cardiological problems and heart failure in particular may experience noticeable cognitive deficits and increased risk of developing Alzheimer's disease. Possible reasons include impaired blood supply to the brain and dysfunction of the hippocampus, which is the memory's control center," explained André Fischer, research group leader at the DZNE's Göttingen site and professor at the Department of Psychiatry and Psychotherapy at UMG. "Yet, there is a lack of therapies to effectively treat cognitive deficits in people with heart problems. This is because it is completely unclear which deficiencies are triggered in neurons. There was no data on this so far."

Stressed Cells

Now, a team led by Prof. André Fischer and Prof. Karl Toischer (Clinic of Cardiology and Pneumology at UMG and DZHK's Göttingen site) is presenting findings on this subject for the first time. The researchers observed in mice that impaired gene activity developed in the hippocampus as a result of heart problems. "In memory tests, mice with heart failure performed significantly worse than their healthy mates," Fischer explained. "We then examined the neurons of the hippocampus. In the mice with heart failure, we found increased cellular stress pathways and altered gene activity in neurons."

Tight Windings

The genome of a mouse -- and also of humans -- comprises around 20,000 genes. In any given cell, however, only a part of them is active, switched on, so to speak. This is not a mere on or off state: the activity can be strong or less strong. This depends, among other things, on how tightly the DNA (the thread-like molecule that carries the genome) is wound and how accessible the genes on it are. In both mice and humans, the DNA is more than a meter long. But in a cell, the molecule is so tightly packed that it fits into the nucleus. "Genes can only be active if they are accessible to the cell's machinery. To this end, the DNA needs to be wound a little more loosely at the relevant sites. This is similar to a ball of yarn with loops sticking out of it," said Fischer. In the current study, the DNA was found to be more tightly wound in neurons of mice with heart problems than in healthy mates. Various genes important for hippocampal function were therefore less active than in healthy mice.

A Drug Improved Memory

The scientists identified chemical changes in the histones as the cause of the tight winding. Histones are special proteins: The DNA wraps around them, much like yarn around a spool of thread. Fischer's research group has been studying histones and other players that influence gene activity for quite some time -- in technical jargon they are called "epigenetic mechanisms." In this context, the researchers are also investigating drugs. In previous studies, they were able to show that the cancer drug "vorinostat" can alleviate genetically driven as well as age-related memory problems in mice. Currently, vorinostat is being investigated for the therapy of people with Alzheimer's in a clinical trial of the DZNE. In the current study, the scientists treated mice with heart failure with this drug. They found that the heart's pumping capacity did not change significantly, but memory performance improved.

Interdisciplinary Cooperation

"Vorinostat has been shown to act on histones and thus on gene activity. Our study thereby provides initial clues about the molecular processes that contribute to cognitive dysfunction following heart problems, and it indicates potential approaches for therapy," Fischer commented on the results. "Fact is, however, that we do not yet understand why, as a result of heart failure, gene activity in the hippocampus is disturbed. What is the role of the deficient blood supply to the brain? Does the troubled heart release substances that affect the histones? We intend to investigate this in patients with heart problems. As with our current study, which involved experts from neuroscience and cardiac research, we aim to address these questions in an interdisciplinary way."

https://www.sciencedaily.com/releases/2021/02/210226121252.htm