Replacing social media use with physical activity

September 7, 2022

Science Daily/Ruhr-University Bochum

If you spend 30 minutes less on social media every day and engage in physical activity instead, you do a lot to improve your mental health. This is shown in a study conducted by a team from the Mental Health Research and Treatment Center at Ruhr-Universität Bochum headed by assistant professor Dr. Julia Brailovskaia. Participants who followed this advice for two weeks felt happier, more satisfied, less stressed by the Covid-19 pandemic and less depressed than a control group. These effects lasted even six months after the study had ended. The researchers published their findings in the Journal of Public Health on Sept. 2, 2022.

The downside of social media

In times of lockdowns and contact restrictions due to the Covid-19 pandemic, social media channels like Instagram, TikTok, Facebook, Twitter and WhatsApp ensured that we still felt connected to other people. They distracted us from the stress brought about by the pandemic, which caused many people to experience anxiety, insecurities, and hopelessness. But social media consumption has also its drawbacks. Heavy use can lead to addictive behaviour that manifests itself in, for example, a close emotional bond to the social media. In addition, fake news and conspiracy theories can spread uncontrollably on social channels and trigger even more anxiety.

"Given that we don't know for certain how long the coronavirus crisis will last, we wanted to know how to protect people's mental health with services that are as free and low-threshold as possible," explains Julia Brailovskaia. To find out whether the type and duration of social media use can contribute to this, she conducted an experimental study as part of her fellowship at the Center for Advanced Internet Studies (CAIS).

A two-week experiment

She and her team recruited a total of 642 volunteers, assigning them randomly to one of four groups of roughly equal size. The first group reduced the daily social media consumption by 30 minutes during an intervention period of two weeks. Since previous studies had shown that physical activity can increase well-being and reduce depressive symptoms, the second group increased the duration of physical activity by 30 minutes daily during this period, while continuing to use social media as usual. The third group combined both, reducing social media use and increasing physical activity. A control group didn't change the behaviour during the intervention phase.

Before, during and up to six months after the two-week intervention phase, the participants responded to online surveys on the duration, intensity and emotional significance of their social media use, physical activity, their satisfaction with life, their subjective feeling of happiness, depressive symptoms, the psychological burden of the Covid-19 pandemic and their cigarette consumption.

Healthy and happy in the age of digitalisation

The findings clearly showed that both reducing the amount of time spent on social media each day and increasing physical activity have a positive impact on people's well-being. And particularly the combination of the two interventions increases one's satisfaction with life and subjective feeling of happiness and reduces depressive symptoms. The effects last for a long time: even six months after the two-week intervention phase had ended, participants in all three intervention groups spent less time on social media than before: namely about a half hour in the groups that had either reduced social media time or increased their daily exercise, and about three-quarters of an hour in the group that had combined both measures. Six months after the intervention, the combination group engaged one hour and 39 minutes more each week in physical activity than before the experiment. The positive influence on mental health continued throughout the entire follow-up period.

"This shows us how vital it is to reduce our availability online from time to time and to go back to our human roots," concludes Julia Brailovskaia. "These measures can be easily implemented into one's everyday life and they're completely free -- and, at the same time, they help us to stay happy and healthy in the digital age."

https://www.sciencedaily.com/releases/2022/09/220907105433.htm

Insomnia increases the likelihood of memory decline in older adults

Longitudinal study shows the psychological disorder is an important comorbidity for dementia and other cognitive impairments

September 6, 2022

Science Daily/Concordia University

A new Canadian study has found that older people with insomnia are at greater risk of developing memory decline and long-term cognitive impairment such as dementia.

The study, published in the journal SLEEP, is based on data from more than 26,000 participants of the Canadian Longitudinal Study on Aging, all aged between 45 and 85. The researchers compared completed self-reported evaluations of sleep and memory and neuropsychological testing in several cognitive domains from 2019 and a follow-up in 2022. Participants who reported worsening sleep quality in that three-year interval also had greater odds of reporting subjective memory decline.

"We found that insomnia specifically was related to worse memory performance compared to those who have some insomnia symptoms alone or no sleep problems at all," says the study's co-lead author Nathan Cross, a postdoctoral fellow at the Sleep, Cognition and Neuroimaging Lab. "This deficit in memory was specific, as we also looked at other cognitive function domains such as attention span multi-tasking. We only found differences in memory."

Jean-Louis Zhao at the Université de Montréal was the study's co-lead. Lisa Kakinami and Thanh Dang-Vu of the PERFORM Centre contributed to the study, as did Chun Yao and Ronald Postuma from McGill University and Julie Carrier and Nadia Gosselin at UdeM.

Big data and a sharp focus

Unlike previous studies on sleep quality, Cross says, this one benefits from its very large data set and its focus on sleep disorders. Insomnia, he points out, has been classified as a psychological disorder in the Diagnostic and Statistical Manual of Mental Disorders, the primary reference handbook used by physicians worldwide. Insomnia is not just tossing and turning for a time before bed: "A diagnosis requires symptoms of difficulty falling asleep, staying asleep or waking too early three nights a week over a period of three months. Additionally, those with insomnia must report that this sleep problem causes them difficulty in the daytime," Cross explains.

For this study, the researchers grouped their subjects into one of three categories: those who reported no sleep problems at the 2019 baseline, those who had some insomnia symptoms and those who developed probable insomnia. When they looked at the data from 2022 follow-up, those who had reported a worsening of sleep quality -- from no symptoms to some or probable insomnia, or from some symptoms to probable insomnia -- were more likely to report memory decline or have it diagnosed by their physician. They were also more likely to show higher prevalence of anxiety, depression, daytime sleepiness, have breathing interruptions during sleep, other sleep-related issues, smoking and a greater body mass index (BMI) score. All of these are considered risk factors for cognitive decline and dementia. Additionally, the study found that men with insomnia perform worse on memory tests than women, suggesting that older men may be at greater risk.

"However, there is some good news: sleep disorders like insomnia can be treated," Cross adds. "This highlights the importance of properly diagnosing and managing insomnia as early as possible in older adults. Adequately treating insomnia disorder might become an important preventive measure for cognitive decline and mitigate the incidence of dementia in later life."

https://www.sciencedaily.com/releases/2022/09/220906134013.htm

How does nature nurture the brain?

Study shows that a one-hour walk in nature reduces stress-related brain activity

September 6, 2022

Science Daily/Max Planck Institute for Human Development

Living in a city is a well-known risk factor for developing a mental disorder, while living close to nature is largely beneficial for mental health and the brain. A central brain region involved in stress processing, the amygdala, has been shown to be less activated during stress in people who live in rural areas, compared to those who live in cities, hinting at the potential benefits of nature. "But so far the hen-and-egg problem could not be disentangled, namely whether nature actually caused the effects in the brain or whether the particular individuals chose to live in rural or urban regions," says Sonja Sudimac, predoctoral fellow in the Lise Meitner Group for Environmental Neuroscience and lead author of the study.

To achieve causal evidence, the researchers from the Lise Meitner Group for Environmental Neuroscience examined brain activity in regions involved in stress processing in 63 healthy volunteers before and after a one-hour walk in Grunewald forest or a shopping street with traffic in Berlin using functional magnetic resonance imaging (fMRI). The results of the study revealed that activity in the amygdala decreased after the walk in nature, suggesting that nature elicits beneficial effects on brain regions related to stress.

"The results support the previously assumed positive relationship between nature and brain health, but this is the first study to prove the causal link. Interestingly, the brain activity after the urban walk in these regions remained stable and did not show increases, which argues against a commonly held view that urban exposure causes additional stress," explains Simone Kühn, head of the Lise Meitner Group for Environmental Neuroscience.

The authors show that nature has a positive impact on brain regions involved in stress processing and that it can already be observed after a one-hour walk. This contributes to the understanding of how our physical living environment affects brain and mental health. Even a short exposure to nature decreases amygdala activity, suggesting that a walk in nature could serve as a preventive measure against developing mental health problems and buffering the potentially disadvantageous impact of the city on the brain.

The results go in line with a previous study (2017, Scientific Reports) which showed that city dwellers who lived close to the forest had a physiologically healthier amygdala structure and were therefore presumably better able to cope with stress. This new study again confirms the importance for urban design policies to create more accessible green areas in cities in order to enhance citizens' mental health and well-being.

In order to investigate benedicial effects of nature in different populations and age groups, the researchers are currently working on a study examining how a one-hour walk in natural versus urban environments impacts stress in mothers and their babies.

https://www.sciencedaily.com/releases/2022/09/220906114334.htm

How the gut may help to drive COVID-19

September 3, 2022

Science Daily/Flinders University

New findings from Flinders University have demonstrated a molecular link between COVID-19 and serotonin cells in the gut.

The research could help provide further clues to what could be driving COVID-19 infection and disease severity and supports previous evidence that antidepressants, known as selective serotonin reuptake inhibitors (SSRIs), could reduce the severity of COVID symptoms.

COVID-19 displays an array of symptoms, which can regularly include gastrointestinal issues such as diarrhoea. Recent research has indicated that these gut symptoms in COVID-19 patients worsen with the severity of the disease, and this is linked to heightened gut-derived serotonin, released to cause gut dysfunction, increasing the body's immune response and potentially worsening patient outcomes.

Published in the world's leading gastrointestinal research journal Gut, this new collaborative study involved three Flinders research teams, including teams led by ARC DECRA Fellow Dr Alyce Martin and FAME Director of Bioinformatics and Human-Microbe Interactions, Professor Robert Edwards.

"Our study endeavoured to understand whether the gut could be a site of disease transmission and what genes might be associated with the virus entering the cells lining the gut wall," says study senior author Professor Damien Keating, Deputy Director of the Flinders Health and Medical Research Institute and Head of the Gut Sensory Systems research group.

The researchers looked at gene expression amongst the different cell types that line the gut wall, analysing whole genome sequences from thousands of individual cells from within the intestine.

They found specialised cells within the gut that synthesised and released serotonin had a highly enriched expression of a particular SARS-CoV-2 receptor and were the only type of cell that expressed all the genes associated with COVID-19.

"Many genes linked to COVID-19 were found expressed in the different cell types lining the gut wall but only serotonin cells expressed all three receptors for the virus," says Professor Keating.

"Expression of all three SARS-CoV-2 receptors triples the rate of cell infectivity, compared to expression of only two receptors."

With the exact sites of infection and the primary drivers of COVID-19 disease severity not yet fully understood, the authors say this study provides important information on the gut's role in the virus.

"Our study adds further evidence that COVID-19 is far more likely to infect cells in the gut and increase serotonin levels through direct effects on specific gut cells, potentially worsening disease outcomes," says Professor Keating.

"It also provides further support to emerging clinical evidence that antidepressant drugs, which block serotonin transport around the body, may serve as a beneficial treatment.

"As COVID-19 continues to circulate, further research will be required to advance our understanding of the gut's role in this virus and continue to find treatment options to work alongside vaccinations."

https://www.sciencedaily.com/releases/2022/09/220901135944.htm

Study calls for change in guidance about eating fish during pregnancy

September 6, 2022

Science Daily/University of Bristol

A woman's mercury level during pregnancy is unlikely to have an adverse effect on the development of the child provided that the mother eats fish,

The findings, which drew together analyses on over 4,131 pregnant mothers from the Children of the 90s study in the UK, with similar detailed studies in the Seychelles, are published in NeuroToxicology.

Importantly, the researchers also found that it does not appear to matter which types of fish are eaten because the essential nutrients in the fish could be protective against the mercury content of the fish. The more important factor was whether the woman ate fish or not. This contrasts with current advice warning pregnant women not to eat certain types of fish that have relatively high levels of mercury.

Although there are several studies that have considered this question, this research has looked at two contrasting studies of populations with mercury levels measured during pregnancy where the children were followed up at frequent intervals during their childhood.

The first is a study focused on a population in the Seychelles, where almost all pregnant women are fish eaters. The second study considered analyses of data from the University of Bristol's Children of the 90s study (also known as the Avon Longitudinal Study of Parents and Children (ALSPAC)), based in a relatively industrialised area in south-west England where fish are consumed far less frequently. No summary of the findings from this study has been published before.

Although it has been known for some time that the children of women who eat fish in pregnancy are likely to benefit in various ways in regard to their eyesight and intellectual abilities, official advice has included the warning not to eat certain types of fish that have relatively high levels of mercury. As a result, there is the possibility that some women will stop eating any fish 'to be on the safe side'.

Dr Caroline Taylor, Senior Research Fellow and co-author of the study, said: "We found that the mother's mercury level during pregnancy is likely to have no adverse effect on the development of the child provided that the mother eats fish. If she did not eat fish, then there was some evidence that her mercury level could have a harmful effect on the child. This could be because of the benefits from the mix of essential nutrients that fish provides, including long-chain fatty acids, iodine, vitamin D and selenium."

Professor Jean Golding, co-author and Emeritus Professor of Paediatric and Perinatal Epidemiology at the University of Bristol, said: "It is important that advisories from health professionals revise their advice warning against eating certain species of fish. There is no evidence of harm from these fish, but there is evidence from different countries that such advice can cause confusion in pregnant women. The guidance for pregnancy should highlight 'Eat at least two portions of fish a week, one of which should be oily' -- and omit all warnings that certain fish should not be eaten."

https://www.sciencedaily.com/releases/2022/09/220906114315.htm

Frequency of premenstrual anxiety, mood swings a public health issue

More than 64% of women experience mood swings or anxiety

September 6, 2022

Science Daily/University of Virginia Health System

Premenstrual mood swings and anxiety are so common -- experienced by more than 64% of women -- that they represent a "key public health issue globally," according to a new UVA Health study.

The UVA Health study found that most women have premenstrual symptoms every menstrual cycle, and those symptoms regularly affect their day-to-day lives. One of the most common symptoms, regardless of age, is mood swings or anxiety, the researchers found. At least 61% of women in all age groups surveyed reported mood-related symptoms every menstrual cycle, which the researchers say suggests "that premenstrual mood symptoms are a key public health issue globally."

"Our study demonstrates that premenstrual mood symptoms are incredibly common worldwide," said Jennifer L. Payne, MD, the study's senior author and director of the Reproductive Psychiatry Research Program at the University of Virginia School of Medicine. "More important, a majority of women reported that their premenstrual symptoms interfered with their everyday life at least some of the time."

Better Understanding Premenstrual Symptoms

To better understand the type of premenstrual symptoms women experience and how those symptoms affect their daily lives, the researchers analyzed more than 238,000 survey responses from women ages 18-55 from 140 countries on the Flo app, which helps women track their menstrual cycle or track their mood or physical symptoms during and after pregnancy.

The most common symptoms reported were food cravings, experienced by 85.28% of the women surveyed, followed by mood swings or anxiety (64.18%) and fatigue (57.3%), according to researchers from the UVA School of Medicine, Johns Hopkins University and Flo Health. Among the study respondents, 28.61% said their premenstrual symptoms interfered with their everyday life during every menstrual cycle, while an additional 34.84% said their premenstrual symptoms interfered with their everyday life sometimes.

"The incidence of reported premenstrual mood and anxiety symptoms varied significantly by country from a low of 35.1% in Congo to a high of 68.6% in Egypt," Payne said. "Understanding whether differences in biology or culture underlie the country level rates will be an important future research direction."

A group of symptoms -- absentmindedness, low libido, sleep changes, gastrointestinal symptoms, weight gain, headaches, sweating or hot flashes, fatigue, hair changes, rashes and swelling -- was significantly more frequent among older survey respondents, the researchers found. The increase in physical symptoms among older survey respondents "makes sense," the researchers said, as many of these symptoms are associated with perimenopause, a transition period to menopause marked by irregular menstrual cycles.

Payne is hopeful that this survey data will help women get better care by making healthcare providers more aware of how frequently these symptoms -- especially anxiety and mood-related symptoms -- occur.

"There are a number of treatment strategies that are available to treat premenstrual symptoms that interfere with a woman's every day functioning," she said. "Increasing awareness of how common these symptoms are, and that if they impact functioning that there are treatments available, will help women improve their quality of life."

https://www.sciencedaily.com/releases/2022/09/220906083535.htm

High blood pressure awareness, control improved with better access to primary health care

Better access to primary health care was associated with improved high blood pressure awareness and control

September 6, 2022

Science Daily/American Heart Association

Having easier access to primary care physicians may increase high blood pressure awareness and control regardless of where a person lives, according to new research published today in Circulation: Cardiovascular Quality and Outcomes, a peer-reviewed journal of the American Heart Association.

According to the American Heart Association, nearly half of all Americans have hypertension (high blood pressure), and many don't even know they have it. High blood pressure is often called the "silent killer" because high blood pressure often has no obvious symptoms. The best ways to protect yourself are to be aware of the risks and make healthy life changes that matter.

In a new study, researchers note that health care professionals at community clinics and primary care practices may help expand awareness and detection of high blood pressure by providing affordable treatment and management. High blood pressure is a leading preventable risk factor for cardiovascular disease, and effective blood pressure control reduces the associated cardiovascular health risks.

"Access to primary care is the key to hypertension management, however, many Americans have limited access to primary care where they live. This is especially true of people in economically disadvantaged neighborhoods or people from diverse racial and ethnic groups, particularly among African American individuals," said senior study author Brisa Aschebrook-Kilfoy, Ph.D., an associate professor of public health sciences at the University of Chicago in Illinois.

It is well known that better access to primary health care is linked to improved high blood pressure awareness and control. This study sought to clarify if people living in disadvantaged neighborhoods may benefit from better access to primary care health professionals.

In this study, neighborhood socioeconomic status was assessed using the Area Deprivation Index (ADI) created by the Health Resources & Services Administration (HRSA) over three decades ago. The ADI was chosen because it allows for rankings of neighborhoods by socioeconomic disadvantage in a region of interest (e.g., at the state or national level), and it is valuable to inform health delivery and policy, especially for the most disadvantaged neighborhood groups. ADI is composed of 17 indicators covering income, education, employment and housing quality. In this study, socioeconomically disadvantaged neighborhoods were defined as those in census tracts ranked in the 50th percentile and above.

"Some argue that minority health disparities are solely the product of socioeconomic factors, or that increasing the number of primary care professionals in diverse racial and ethnic neighborhoods would not reduce health disparities and improve public health. To our knowledge, there is little research to support or rebut this argument," said first study author Jiajun Luo, Ph.D., a post-doctoral fellow at the University of Chicago's Institute for Population and Precision Health. "We conducted this study to examine whether accessibility of primary care is associated with better hypertension control and awareness across various socioeconomic and neighborhood factors."

The study examined Chicago, one of the most racially segregated cities in the U.S. Chicago's South Side is the largest African American urban community in the U.S., with substantial challenges including poverty, violence and decreased access to fresh, healthy foods. According to the study, a 30-year gap in life expectancy has been observed between people who live in the South Side neighborhoods and Chicago's wealthier northern neighborhoods, which may be largely attributable to higher rates of high blood pressure, heart disease and stroke.

The researchers analyzed the health data for more than 5,000 predominantly African American adults who participated in the Chicago Multiethnic Prevention and Surveillance Study (COMPASS) between 2013 to 2019. COMPASS is a long-term initiative at the University of Chicago exploring the health of Chicagoans, primarily those who live in communities on the South Side. MAPSCorps, a non-profit organization, provided location information for primary care professionals providing care in those Chicago neighborhoods.

More than half of the study participants were smokers, and they reported an annual household income of less than $15,000 and more than 37% were obese according to body mass index (BMI). Most of the study population resided in a Chicago neighborhood with an ADI rank higher than the 70th percentile (communities with the most disadvantages).

Researchers also evaluated spatial accessibility, which is a composite score that considers the distance between an individual's residence and local primary health care facilities; the number of physicians-to-population ratio; and the effect of distance to primary care on an individual's willingness to seek primary health care. A higher spatial accessibility score indicated better accessibility to primary care. The primary health care professionals included family physicians, general practitioners and general internists.

The research found: ®

• Nearly 80% of the COMPASS participants had documented hypertension, using the standard American Heart Association guideline-based blood pressure criteria of measures ?130 mm Hg systolic (top number) or ?80 mm Hg diastolic (bottom number).

• Nearly 38% of those with hypertension did not have their blood pressure under control (were not receiving treatment based on self-report), and 41% were not aware they had high blood pressure.

• Spatial accessibility scores ranged from 16.4 (lower access to primary care) to 86.6 (higher access) per 100,000 residents.

• Adults living in areas with the fewest primary health care professionals had 37% increased odds of having hypertension when compared to the adults living in neighborhoods with the most primary care physicians.

• The listed associations existed in both poor and wealthy neighborhoods, suggesting that residents in all neighborhoods may benefit from increasing the number of primary care professionals.

• When stratified by neighborhood type (advantaged or disadvantaged), accessibility to primary care was not associated with use of anti-hypertension medications among those who reported they had hypertension prior to enrolling in the study.

"Based on these findings, we need to encourage primary care physicians to expand access to people who live in underserved communities with the fewest primary care professionals," Aschebrook-Kilfoy said. "Mobile health units may be one approach to increase primary care service in underserved areas by eliminating the challenge of getting transportation to and from an office visit. The use of anti-hypertension medications also needs to be studied and addressed, especially as it was not linked to primary care accessibility in this study."

While the method used in this study to measure spatial accessibility can be used anywhere with sufficient location information about primary care professionals, a major limitation of this study is that these specific results may not be representative of other communities and population groups, such as middle-class urban communities or people from other diverse racial and ethnic groups, etc.

https://www.sciencedaily.com/releases/2022/09/220906083550.htm

Low testosterone may increase risk of COVID-19 hospitalization for men

Boosting testosterone in men with low levels may reduce serious illness

September 2, 2022

Science Daily/Washington University School of Medicine

Among men diagnosed with COVID-19, those with low testosterone levels are more likely to become seriously ill and end up in the hospital than men with normal levels of the hormone, according to a study by researchers at Washington University School of Medicine in St. Louis and Saint Louis University School of Medicine.

The team analyzed the cases of 723 men who tested positive for COVID-19, mostly in 2020 before vaccines were available. The data indicate that low testosterone is an independent risk factor for COVID-19 hospitalization, similar to diabetes, heart disease and chronic lung disease.

They found that men with low testosterone who developed COVID-19 were 2.4 times more likely to require hospitalization than men with hormone levels in the normal range. Further, men who were once diagnosed with low testosterone but successfully treated with hormone replacement therapy were no more likely to be hospitalized for COVID-19 than men whose testosterone levels had always tested in the normal range.

The findings, published Sept. 2 in JAMA Network Open, suggest that treating men with low testosterone may help protect them against severe disease and reduce the burden on hospitals during COVID-19 waves.

"It is very likely that COVID-19 is here to stay," said co-senior author Abhinav Diwan, MD, a professor of medicine at Washington University. Diwan, who treats patients at Barnes-Jewish Hospital, is also a professor of cell biology & physiology, and of obstetrics & gynecology. "Hospitalizations with COVID-19 are still a problem and will continue to be a problem because the virus keeps evolving new variants that escape immunization-based immunity. Low testosterone is very common; up to a third of men over 30 have it. Our study draws attention to this important risk factor and the need to address it as a strategy to lower hospitalizations."

Diwan and co-senior author Sandeep Dhindsa, MD, an endocrinologist at Saint Louis University, previously had shown that men hospitalized with COVID-19 have abnormally low testosterone levels. However, severe illness or traumatic injury can cause hormone levels to drop temporarily. Data from men who are already hospitalized with COVID-19 doesn't really answer the question of whether low testosterone is a risk factor for severe COVID-19 or a result of it. For that, the researchers needed to know whether men with chronically low testosterone levels get sicker than men with normal levels.

Diwan, Dhindsa and colleagues -- including co-author Cosette Champion, MD, an internal medicine resident at Barnes-Jewish -- conducted a chart review of patients at SSM Health and BJC HealthCare, two major hospital systems in the St. Louis area. They identified 723 men whose testosterone levels had been measured between Jan. 1, 2017, and Dec. 31, 2021, and who had documented cases of COVID-19 in 2020 or 2021. In some cases, testosterone levels were measured after the patient recovered from COVID-19. Since low testosterone is a chronic condition, men who tested low a few months after recovering from COVID-19 probably had low levels before as well, Dhindsa said.

The researchers identified 427 men with normal testosterone levels, 116 with low levels, and 180 who previously had low levels but were being successfully treated, meaning that they were on hormone replacement therapy and their testosterone levels were in the normal range at the time they developed COVID-19.

"Low testosterone turned out to be a risk factor for hospitalization from COVID, and treatment of low testosterone helped to negate that risk," Dhindsa said. "The risk really takes off below a level of 200 nanograms per deciliter, with the normal range being 300 to 1,000 nanograms per deciliter. This is independent of all other risk factors that we looked at: age, obesity or other health conditions. But those people who were on therapy, their risk was normal."

Men with low testosterone levels can experience sexual dysfunction, depressed mood, irritability, difficulty with concentration and memory, fatigue, loss of muscular strength and a reduced sense of well-being overall. When a man's quality of life is clearly diminished, he is typically treated with testosterone replacement therapy. When the symptoms are mild, though, doctors and patients may hesitate to treat.

The two main concerns related to testosterone therapy are an increased risk of prostate cancer and heart disease. Prostate cancer is common in older men, and it is often driven by testosterone. Boosting testosterone could possibly speed the growth of such cancers, worsening the disease. For heart disease, the evidence for risk is more ambiguous. A large clinical trial on the relationship between heart health and testosterone supplementation is expected to be completed soon.

"In the meantime, our study would suggest that it would be prudent to look at testosterone levels, especially in people who have symptoms of low testosterone, and then individualize care," said Diwan, whose specialty is cardiology. "If they are at really high risk of cardiovascular events, then the doctor could engage the patient in a discussion of the pros and cons of hormone replacement therapy, and perhaps lowering the risk of COVID hospitalization could be on the list of potential benefits."

This study is observational, so it only suggests -- not proves -- that boosting testosterone levels may help men avoid severe COVID-19, Diwan cautioned. A clinical trial would be needed to demonstrate conclusively whether such a strategy works.

https://www.sciencedaily.com/releases/2022/09/220902111333.htm

COVID rekindled an appreciation of nature for many

An opportunity to rediscover why the great outdoors are so great in the first place

September 2, 2022

Science Daily/University of Connecticut

The pandemic has impacted our lives in a multitude of ways, many of which will no doubt be felt for years to come. While many of those effects are clearly negative, UConn researchers have identified at least one positive impact -- our perception of natural spaces changed. The findings are published in Nature Scientific Reports.

As people flocked to outdoor spaces for recreation in the spring of 2020, Sohyun Park, assistant professor in UConn's College of Agriculture, Health and Natural Resources Department of Plant Science and Landscape Architecture, noticed some interesting trends: more people were on the trails, and many of those people had traveled from far away to enjoy nature.

Park was also part of the team for the Connecticut Trail Census and co-wrote a paper about the trends.

Sohyun Park of the Department of Plant Science and Landscape Architecture in her office in the W.B. Young Building. Mar. 8, 2022. (Jason Sheldon/UConn Photo)

"What's interesting was rural trail use increased compared to urban trails," Park says. "I wanted to try to find out how people were changing their mindset or their attitudes or perceptions."

To do this, Park and co-authors Seungman Kim and Jaehoon Lee of Texas Tech University, and Biyoung Heo of James Corner Field Operations, looked to social media data and machine learning techniques to help make sense of the vast quantities of information on Twitter and try to find a pattern among those data, says Park. They utilized Twitter's Application Programming Interface (API), which allows researchers to obtain aggregated data from Twitter posts.

"We wanted to know from the people who have been in greenspaces, what were they doing and what they were writing about on Twitter. We utilized very innovative and advanced levels of machine learning methods," says Park. "The machine categorized the keywords and classified them into several human-recognizable groups. One group was nature related. The second group is all traditional park-related activities and the third one is obviously the COVID-related one, so mask wearing and social distancing, and things like that."

A newfound appreciation for nature

Though what people were doing in the parks did not change significantly, the researchers noticed some significant changes in keyword usage between pre-pandemic and pandemic Twitter, with people frequently referencing nature, and their experiences within it.

"Users began to put the word 'nature' and nature-related activities or nature-related pictures on their Twitter," Park says. "It was very interesting because, in the past, there were not many keywords like that, but people used keywords like 'playing', 'walking the dog', 'baseball', and other traditional, active park activities that they were enjoying while they were there in the parks. If you look at post- 2020 Twitter, you can also see keywords thanking God or showing appreciation for nature, describing the birds singing or water sounds."

What the researchers found was people seemed to have realized a newfound appreciation for nature and greenspaces, especially true for those in urban settings. As a landscape architect, Park was interested to see if there was something more to the findings and perhaps if there might be some design implications for the results.

Common features in modern parks include benches, walking paths, and sports fields, for instance. However, Park says the results of the paper seem to suggest that natural greenspaces appeal to people differently.

"We might want to go back to the origin of public parks like those Olmsted designed," Park says. "In his time in 19th century, there was a lot of hustle and bustle in the city, and they wanted to have space for people to find respite and peace. We might want to go back to that era living with a 21st century health crisis and try to rethink about the design principles."

Park says to imagine Manhattan's Central Park, which hosts ponds, wooded areas, and meadows. Most of those natural features were introduced artificially and were not there in the first place. Compare this with contemporary parks:

"Modern parks may be well managed, maintained, and manicured, everything is clean and tidy," Park says. "There are some seating areas, paved surfaces, and structures where you can play something with your friends and family members, but not really in a naturalistic style. People can feel that in public spaces."

The outdoors as essential resource for overall well-being

Greenspaces impact mental, physical, and spiritual health, and Park reasons that these natural elements might be essential in public spaces, particularly for those who have less access to the public parks, or marginalized communities that don't have any green areas at their residences.

"I'm arguing that parks are not only recreational spaces; greenspaces and parks serve as essential amenities for all including those with low incomes or disabilities, and the elderly," Park says. "Parks need inclusive planning approaches that might be added to the current principles for park development."

Park explains that many people are involved in the planning, design, and management of parks and greenspaces. The tricky part is that the more naturalistic, garden concept for public parks may require more planning and maintenance, and therefore these design features rely more heavily on resources and budgets.

"In the long term, I think that will be the direction that we need to go and now officials and park managers need to work together with those who are living nearby so that we can have some kind of co-managing type of approaches to the future," Park says.

This study highlights the importance of those design features and their roles in our emotional and spiritual well-being, and Park says it is important for the public to advocate for our greenspaces. Research like this can inform decision-making.

"It is important for the public and decision-makers to understand that ultimately, we need to have a budget to have more natural features and nature-oriented programs in the park. We all need to be more active in terms of the things that towns are doing. That can start with joining your town's Conservation Commission or attending monthly meetings. Participate and make your voice heard. That makes a huge change and can impact big decisions. Sometimes these decision makers are really grounded by how the stakeholders are feeling so giving some input and feedback on the public decision-making should be the first step. It is empowering and more people need to be involved in public planning."

https://www.sciencedaily.com/releases/2022/09/220902103241.htm

Circadian rhythm disruption found to be common among mental health disorders

Researchers spotlight links and propose investigation into molecular underpinnings

September 1, 2022

Science Daily/University of California - Irvine

Anxiety, autism, schizophrenia and Tourette syndrome each have their own distinguishing characteristics, but one factor bridging these and most other mental disorders is circadian rhythm disruption, according to a team of neuroscience, pharmaceutical sciences and computer science researchers at the University of California, Irvine.

In an article published recently in the Nature journal Translational Psychiatry, the scientists hypothesize that CRD is a psychopathology factor shared by a broad range of mental illnesses and that research into its molecular foundation could be key to unlocking better therapies and treatments.

"Circadian rhythms play a fundamental role in all biological systems at all scales, from molecules to populations," said senior author Pierre Baldi, UCI Distinguished Professor of computer science. "Our analysis found that circadian rhythm disruption is a factor that broadly overlaps the entire spectrum of mental health disorders."

Lead author Amal Alachkar, a neuroscientist and professor of teaching in UCI's Department of Pharmaceutical Sciences, noted the challenges of testing the team's hypothesis at the molecular level but said the researchers found ample evidence of the connection by thoroughly examining peer-reviewed literature on the most prevalent mental health disorders.

"The telltale sign of circadian rhythm disruption -- a problem with sleep -- was present in each disorder," Alachkar said. "While our focus was on widely known conditions including autism, ADHD and bipolar disorder, we argue that the CRD psychopathology factor hypothesis can be generalized to other mental health issues, such as obsessive-compulsive disorder, anorexia nervosa, bulimia nervosa, food addiction and Parkinson's disease."

Circadian rhythms regulate our bodies' physiological activity and biological processes during each solar day. Synchronized to a 24-hour light/dark cycle, circadian rhythms influence when we normally need to sleep and when we're awake. They also manage other functions such as hormone production and release, body temperature maintenance and consolidation of memories. Effective, nondisrupted operation of this natural timekeeping system is necessary for the survival of all living organisms, according to the paper's authors.

Circadian rhythms are intrinsically sensitive to light/dark cues, so they can be easily disrupted by light exposure at night, and the level of disruption appears to be sex-dependent and changes with age. One example is a hormonal response to CRD felt by pregnant women; both the mother and the fetus can experience clinical effects from CRD and chronic stress.

"An interesting issue that we explored is the interplay of circadian rhythms and mental disorders with sex," said Baldi, director of UCI's Institute for Genomics and Bioinformatics. "For instance, Tourette syndrome is present primarily in males, and Alzheimer's disease is more common in females by a ratio of roughly two-thirds to one-third."

Age also is an important factor, according to scientists, as CRD can affect neurodevelopment in early life in addition to leading to the onset of aging-related mental disorders among the elderly.

Baldi said an important unresolved issue centers on the causal relationship between CRD and mental health disorders: Is CRD a key player in the origin and onset of these maladies or a self-reinforcing symptom in the progression of disease?

To answer this and other questions, the UCI-led team suggests an examination of CRD at the molecular level using transcriptomic (gene expression) and metabolomic technologies in mouse models.

"This will be a high-throughput process with researchers acquiring samples from healthy and diseased subjects every few hours along the circadian cycle," Baldi said. "This approach can be applied with limitations in humans, since only serum samples can really be used, but it could be applied on a large scale in animal models, particularly mice, by sampling tissues from different brain areas and different organs, in addition to serum. These are extensive, painstaking experiments that could benefit from having a consortium of laboratories."

He added that if the experiments were conducted in a systematic way with respect to age, sex and brain areas to investigate circadian molecular rhythmicity before and during disease progression, it would help the mental health research community identify potential biomarkers, causal relationships, and novel therapeutic targets and avenues.

https://www.sciencedaily.com/releases/2022/09/220901200635.htm

New method could aid Alzheimer's research by predicting risk before symptoms start

Researchers demonstrate how DNA-based method enables nomination of key proteins linked to Alzheimer's

Science Daily/September 1, 2022

PLOS

Researchers have developed a new method to identify people who are at greater genetic risk of developing Alzheimer's disease before any symptoms appear -- which could help speed creation of novel treatments. Manish Paranjpe of the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, United States, and colleagues present these findings in the open-access journal PLOS Genetics on September 1.

People with Alzheimer's disease experience gradual loss of memory and other cognitive functions. While some treatments can ease symptoms, it has been challenging to develop treatments to prevent or slow disease progression. Some clinical trials investigating potential treatments may have been unsuccessful because they involved patients whose disease was too advanced to be treated. Better methods to identify people at high risk of developing Alzheimer's could aid treatment research.

To help meet that need, Paranjpe and colleagues analyzed data on 7.1 million common DNA variants -- alterations to the standard DNA sequence -- from an earlier study that included tens of thousands of people with or without Alzheimer's. They used this data to develop a novel method that predicts a person's risk of Alzheimer's, depending on which DNA variants the person has. Then, they refined and validated the method with data from more than 300,000 additional people.

The researchers note that their DNA-based method is unlikely to be suitable for doctors to predict a patient's risk of Alzheimer's because it may be less accurate for non-European populations, it could impact insurance, and it could cause anxiety without the relief of reliable preventive treatments. However, it could be applied to speed Alzheimer's research.

To demonstrate the potential of the new method, the researchers applied it to determine the risk of Alzheimer's for each of 636 blood donors and examined whether blood levels of any of 3,000 proteins were higher or lower than normal for those identified as being high-risk. The analysis surfaced 28 proteins that could be linked to Alzheimer's risk, including several that have never been studied in Alzheimer's research. Studying these proteins could uncover new directions for drug development.

Future research could help replicate and confirm these findings and expand on them, such as by considering populations with non-European ancestry.

Senior author Dr. Amit V. Khera adds, "We developed a genetic predictor of Alzheimer's disease associated with both clinical diagnosis and age-dependent cognitive decline. By studying the circulating proteome of healthy individuals with very high versus low inherited risk, our team nominated new biomarkers of neurocognitive disease."

https://www.sciencedaily.com/releases/2022/09/220901151607.htm

Double burden of paid and unpaid labor leading to poorer mental health in women

New research reveals unpaid labor is associated with poorer mental health in employed women, but the effects are less apparent for men

September 1, 2022

University of Melbourne

Women still do the bulk of unpaid work at home while also holding down a job. A new review finds this double burden is taking a toll on their mental health.

New research reveals unpaid labour is associated with poorer mental health in employed women, but the effects are less apparent for men.

Published in the Lancet Public Health, University of Melbourne researchers have conducted a review -- the first of its kind -- to bring together and assess the existing evidence examining the gendered association between unpaid labour and mental health.

Of the 14 studies included -- totalling more than 66,800 participants worldwide -- five examined unpaid labour (inclusive of care), nine examined housework time and, of these, four also examined childcare.

Researchers found that in addition to the economic penalty women experience shouldering most of the world's unpaid labour load, there is a mental health cost as well.

Overall, in 11 of the 14 studies examined, women self-reported increased depressive or psychological distress symptoms with increasing unpaid labour demands. For men, only three out of a possible 12 studies reported any negative association.

"We found substantial gender differences in exposure to unpaid labour, with women uniformly doing more in every geographical and time setting -- in more than 35 countries -- around the world," research lead Jen Ervin said.

"This double burden of paid and unpaid work exposures women to greater risk for overload, time poverty and poorer mental health. Crucially, women are also routinely trading off paid work hours to meet their disproportionally high unpaid labour responsibilities."

Ms Ervin said the study highlights the need for greater attention and meaningful action to drive greater equity in the division of unpaid labour.

"There is an undeniable mental load that accompanies unpaid labour and family responsibilities. Reducing the disproportionate unpaid labour burden on women, by enabling men to take on their equal share, has the potential to improve women's mental health," she said.

In addition, researchers say substantive policy changes, such as universal childcare and normalising flexible working arrangements for men are urgently required to enable real change.

Researchers conclude that this review highlights the need for further high-quality longitudinal research in this area, the need to better understand nuances within different dimensions of unpaid labour, as well as the need for a consistent approach in how unpaid labour is defined and measured.

https://www.sciencedaily.com/releases/2022/08/220831210017.htm

Positive neighbor involvement important if teens don't develop mother-child bond

August 31, 2022

Science Daily/University of Michigan

Teens who live in neighborhoods with trusted, engaged adults can still develop critical social skills that were not nurtured early in life, according to a new University of Michigan study.

Previous studies have shown the importance of early mother-child bonding that contributes to teens having social skills, such as positive behaviors that optimize relationships with others, solid academic performance and self-management of emotions.

But what happens when that connection isn't formed? Social cohesion -- or the trust and bonds among neighbors -- can benefit the adolescents, researchers said.

The study focused on social skills among 15-year-olds as a function of early attachment between mothers -- also considered primary caregivers -- and their 3-year-old kids, as well as neighborhood social cohesion.

Data from 1,883 children ages 1, 3 and 15 came from the Fragile Families and Child Wellbeing Study, a nationally representative study of children born in 20 U.S. cities between 1998 and 2000.

The present study asked 39 questions to determine the children's attachment, such as "is easily comforted by contact or interaction with mother when crying or otherwise distressed." A higher score indicated a greater level of security in the child's attachment with the mother.

To measure adolescent social skills, behavior questions were asked of the 15-year-old participants. High scores in child attachment were positively correlated with increased adolescent social skills, the study showed.

At age 3, some of the traits reflecting closeness would be "hugs or cuddles with mother without being asked to do so," "responds positively to helpful hints from mother," and "when a mother says follow, child does so willingly."

High scores in neighborhood social cohesion at age 3 were positively correlated with increased adolescent social skills. And when the bond between the mother-child wasn't strong, the impact neighbors had on kids' social skills was important, the research indicated.

"Children who live in neighborhoods with a high degree of social cohesion may have more opportunities to engage within their community and interact with other trusted adults, as well as form friendships with children," said study lead author Sunghyun Hong, a doctoral student of social work and psychology.

These connections with other sources of support may be the driving force behind the buffering impact of social cohesion on social skills for children who had insecure attachments to their caregivers

"This underscores the value of children having access to supportive and loving relationships with the mother and the surrounding community, even from early childhood," Hong said.

The data was collected in the late 90s to early 20s, in which mothers were frequently the primary caregivers. However, in recent decades, the definition of primary caregivers has been expanding with families having diverse forms, including more fathers who are engaged in co-parenting and are the sole primary caregiver. Thus, if the research involved father, the study's results would be similar, Hong said.

The findings, which appear in the Journal of Social and Personal Relationships, show that living in a neighborhood with high social cohesion is as important as having high attachment security to the mother," she said.

"This means that when we think about policies and programs to empower our children in the community, we must consider directly supporting the family relations and investing in their surrounding community relations," Hong said.

The study's co-authors were U-M psychology graduate student Felicia Hardi and Kathryn Maguire-Jack, associate professor of social work.

https://www.sciencedaily.com/releases/2022/08/220831095034.htm

Humble leaders can help make groups more effective

Study of teachers links leadership to psychological empowerment

August 31, 2022

Science Daily/Ohio State University

Leaders of teacher groups who were thought of as humble helped improve professionalism and collaboration among team members, new research has shown.

The study, done in China, found that teachers in the Chinese equivalent of professional learning communities (PLCs) were more willing to share their knowledge and expertise when they rated their PLC leaders as being higher in humility.

The reason was that humble leaders made teachers feel more empowered to share their knowledge because they felt psychologically safe to take risks, said study co-author Roger Goddard, professor of educational studies at The Ohio State University.

"A little humility on the part of leaders goes a long way in helping groups be more productive and collaborative," Goddard said.

"When people feel their leader admits mistakes and is open to learning from others, everyone contributes more and makes these groups more effective."

Goddard conducted the study with Yun Qu of Beijing Normal University in China and Jinjie Zhu, a doctoral student in education at Ohio State. The study was published online recently in the journal Educational Studies.

In the United States and elsewhere, PLCs are designed to facilitate professional development through discussions in which teachers share their best practices and what they have learned through their experiences in the classroom.

"Teachers can feel fairly isolated in the classroom," Goddard said. "PLCs help teachers build a sense of community and learn from each other about how to improve classroom instruction."

In China, the equivalent of PLCs are called Teaching Research Groups (TRGs). The leaders of TRGs are experienced teachers who are not traditional administrators, but do serve as supervisors and coordinators and are involved in teacher evaluations, lesson planning and teacher selection.

This study involved 537 teachers from 238 TRGs in a variety of both urban and rural schools in China.

Teachers rated their TRG leaders on three dimensions of humility: their willingness to view themselves accurately, such as admitting when they didn't know how to do something; their appreciation of others' strengths; and their teachability, such as being open to other teachers' advice.

Results showed that teachers who rated their TRG leaders as being higher in humility were more likely to report that they shared their knowledge and expertise in TRG meetings.

"The whole point of these groups is for teachers to share their knowledge, so the fact that humble leaders inspired individuals in their groups to be more willing to do this is very significant," Goddard said.

The study also found why humble leaders were so effective in helping their teachers share their knowledge.

Results showed that in TRGs with more humble leaders, teachers reported higher levels of psychological safety -- they felt they could take risks and knew that others would not act in a way to undermine their efforts.

That feeling of safety led them to feel more psychologically empowered: They felt their jobs had meaning, they had autonomy to do their work, and they felt they were competent and that their work had impact in the school.

So humble leadership led to teachers feeling psychologically safe, which made them feel empowered and ultimately led them to share their experience and knowledge more fully with their colleagues, Goddard said.

"This feeling of teachers that they could safely share their knowledge comes from having a leader who has humility -- an openness to learning from others, a willingness to revise opinions, and an appreciation for the strengths of others," he said.

While this research was done in China, Goddard said he believes the results would be similar in the United States and elsewhere.

"There's a lot of evidence that suggests trust is a key part of successful organizations. And feeling psychologically safe and empowered to share your knowledge in the workplace is part of building trust, and that's what humble leaders help create," he said.

"That is as true in the United States as it is in China."

In the same way, the results should be applicable outside of education.

"Many of the same principles that make successful organizations cut across cultures and fields. It makes sense that humble leaders will build trust and better relationships that will increase the effectiveness of any groups that have to work together," Goddard said.

https://www.sciencedaily.com/releases/2022/08/220831095002.htm

Sharing on social media makes us overconfident in our knowledge

Sharing articles on social media, even when we haven't read them, can lead us to believe we are experts on a topic

August 30, 2022

Science Daily/University of Texas at Austin

Sharing news articles with friends and followers on social media can prompt people to think they know more about the articles' topics than they actually do, according to a new study from researchers at The University of Texas at Austin.

Social media sharers believe that they are knowledgeable about the content they share, even if they have not read it or have only glanced at a headline. Sharing can create this rise in confidence because by putting information online, sharers publicly commit to an expert identity. Doing so shapes their sense of self, helping them to feel just as knowledgeable as their post makes them seem.

This is especially true when sharing with close friends, according to a new paper from Susan M. Broniarczyk, professor of marketing, and Adrian Ward, assistant professor of marketing, at UT's McCombs School of Business.

The research is online in advance in the Journal of Consumer Psychology. The findings are relevant in a world in which it's simple to share content online without reading it. Recent data from the Reuters Institute for the Study of Journalism show only 51% of consumers who "read" an online news story actually read the whole article, while 26% read part, and 22% looked at just the headline or a few lines.

Broniarczyk, Ward and Frank Zheng, a McCombs marketing doctoral alum, conducted several studies that support their theory. In an initial one, the researchers presented 98 undergraduate students with a set of online news articles and told them they were free to read, share, or do both as they saw fit. Headlines included "Why Does Theatre Popcorn Cost So Much" and "Red Meats Linked to Cancer."

Next, they measured participants' subjective and objective knowledge for each article -- what the students thought they knew, and what they actually knew. Reading articles led to increases in both objective and subjective knowledge. Sharing articles also predicted increases in subjective knowledge -- even when students had not read what they chose to share, and thus lacked objective knowledge about the articles' content.

In a second study, people who shared an article about cancer prevention came to believe they knew more about cancer than those who did not, even if they had not read the article.

Three additional studies found this effect occurs because people internalize their sharing into the self-concept, which leads them to believe they are as knowledgeable as their posts make them appear. Participants thought they knew more when their sharing publicly committed them to an expert identity: when sharing under their own identity versus an alias, when sharing with friends versus strangers, and when they had free choice in choosing what to share.

In a final study, the researchers asked 300 active Facebook users to read an article on "How to Start Investing: A Guide for Beginners." Then, they assigned students to a sharing or no sharing group. All participants were told the content existed on several websites and saw Facebook posts with the sites. Sharers were asked to look at all posts and choose one to share on their Facebook page.

Next, in a supposedly unrelated task, a robo-advised retirement planning simulation informed participants that allocating more money to stocks is considered "more aggressive" and to bonds "more conservative," and they received a customized investment recommendation based on their age. Participants then distributed a hypothetical $10,000 in retirement funds between stocks and bonds: Sharers took significantly more investment risk. Those who shared articles were twice as likely to take more risk than recommended by the robo-advisor.

"When people feel they're more knowledgeable, they're more likely to make riskier decisions," Ward said.

The research also suggests there's merit to social media companies that have piloted ways to encourage people to read articles before sharing.

"If people feel more knowledgeable on a topic, they also feel they maybe don't need to read or learn additional information on that topic," Broniarczyk said. "This miscalibrated sense of knowledge can be hard to correct."

https://www.sciencedaily.com/releases/2022/08/220830165307.htm

Brain activity during sleep differs in young people with genetic risk of psychiatric disorders

August 30, 2022

Science Daily/eLife

Young people living with a genetic alteration that increases the risk of psychiatric disorders have markedly different brain activity during sleep, a new study shows.

The brain activity patterns during sleep shed light on the neurobiology behind a genetic condition called 22q11.2 Deletion Syndrome (22q11.2DS) and could be used as a biomarker to detect the onset of neuropsychiatric disorders in people with 22q11.2DS.

22q11.2DS is caused by a gene deletion of around 30 genes on chromosome 22 and occurs in 1 in 3000 births. It increases the risk of intellectual disability, autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and epileptic seizures. It is also one of the largest biological risk factors for schizophrenia. However, the biological mechanisms underlying psychiatric symptoms in 22q11.2DS are unclear.

"We have recently shown that the majority of young people with 22q11.2DS have sleep problems, particularly insomnia and sleep fragmentation, that are linked with psychiatric disorders," says co-senior author Marianne van den Bree, Professor of Psychological Medicine at Cardiff University, UK. "However, our previous analysis was based on parents reporting on sleep quality of their children, and the neurophysiology -- what's happening to brain activity -- has not yet been explored."

An established way of measuring brain activity during sleep is an electroencephalogram (EEG). This measures electrical activity during sleep and features patterns called spindles and slow-wave (SW) oscillations. These features are hallmarks of non-rapid eye movement (NREM) sleep and are thought to aid memory consolidation and brain development. "Because sleep EEG is known to be altered in many neurodevelopmental disorders, the properties and coordination of these alterations can be used as biomarkers for psychiatric dysfunction" explained lead author Nick Donnelly, Clinical Lecturer in General Adult Psychiatry at the University of Bristol, UK

To explore this in 22q11.2DS, the team recorded sleep EEG over one night in 28 young people aged 6-20 years old with the chromosome deletion and in 17 unaffected siblings, recruited as part of the Cardiff University Experiences of Children with copy number variants (ECHO) study, led by Prof. van den Bree. They measured correlations between sleep EEG patterns and psychiatric symptoms, as well as performance in a recall test the next morning.

They found that the group with 22q11.2DS had significant alterations in sleep patterns including a greater proportion of N3 NREM sleep (slow-wave sleep) and lower proportions of N1 (the first and lightest sleep stage) and rapid eye movement (REM) sleep, compared with their siblings. Those carrying the chromosome deletion also had increased EEG power for both slow-wave oscillations and spindles. There was also an increase in the frequency and density of spindle patterns and stronger coupling between the spindle and slow-wave EEG features in the 22q112.DS group. These changes may reflect alterations in the connections within and between areas of the brain that generate these oscillations, the cortex and the thalamus.

Participants also took part in a 2D object location task before sleep, where they had to remember where matching cards were on a screen. They were tested again on the same task in the morning, and the team found that in those with 22q11.2DS, higher spindle and SW amplitudes were associated with lower accuracy. By contrast, in participants without the chromosome deletion, higher amplitudes were linked to higher accuracy in the morning recall test.

Finally, the team estimated the impact of the differences in sleep patterns on psychiatric symptoms in the two groups using a statistical method called mediation. They calculated the total effect of genotype on psychiatric measures and IQ, the indirect (mediated) effect of EEG measures, and then the proportion of the total effect that may be mediated by EEG patterns. They found that the effects on anxiety, ADHD and ASD driven by the 22q11.2 deletion were partially mediated by sleep EEG differences.

"Our EEG findings together suggest a complex picture of sleep neurophysiology in 22q11.2DS and highlight differences that could serve as potential biomarkers for 22q11.2DS-associated neurodevelopmental syndromes," concluded co-senior author Matt Jones, Professorial Research Fellow in Neuroscience, University of Bristol, UK. "Further study will now need to clarify the relationship between psychiatric symptoms, sleep EEG measures and neurodevelopment, with a view to pinpointing markers of brain circuit dysfunction that could inform doctors which patients are most at risk, and support treatment decisions."

https://www.sciencedaily.com/releases/2022/08/220830131627.htm

Good face recognizers can learn faces from fragments

August 31, 2022

Science Daily/University of New South Wales

Good with faces? New research suggests that your ability might be more akin to piecing together a jigsaw puzzle than taking a photograph.

Psychologists at UNSW Sydney and University of Wollongong have challenged the prevailing view that people with exceptional face recognition abilities rely on processing faces holistically.

Instead, they argue, people who are great at learning and remembering new faces -- also known as super recognisers -- can divide new faces into parts, before storing them in the brain as composite images.

"It's been a long-held belief that to remember a face well you need to have a global impression of the face, basically by looking at the centre and seeing the face as a whole," said lead researcher, Dr James Dunn.

"But our research shows that super-recognisers are still able to recognise faces better than others even when they can only see smaller regions at a time. This suggests that they can piece together an overall impression from smaller chunks, rather than from a holistic impression taken in a single glance."

In a paper published today in the journal Psychological Science, the researchers described how they set up an experiment that tested both super recognisers and people with average face recognition skills to see whether revealing only small areas of a face at a time made any difference to super recognisers' superior ability to remember a face.

Not only did super recognisers continue to perform better when only seeing small parts of a face at a time, but they seemed to spend less time looking at the eyes than other participants in the test.

But according to Dr Dunn, the results don't mean that super-recognisers are necessarily doing anything differently than the rest of us.

"It seems that super-recognisers are not processing faces in a qualitatively different way from everyone else," Dr Dunn said. "They are doing similar things to normal people, but they are doing some important things more and this leads to better accuracy."

The setup

The researchers recruited 37 super-recognisers and 68 typical recognisers and sat them before a computer screen. There, they looked at faces through a 'spotlight' that captured up to 60 per cent of the face at the largest aperture, down to just 12 per cent at the smallest aperture, using eye tracking technology.

Each person had five seconds to scan an outline of a face, and only the parts of the face that their gaze illuminated was revealed in detail, with the rest blurred beyond recognition. As they looked around the face, new details of the face were revealed, while the preceding area was again obscured. They looked at a total of 12 faces.

In the next phase they were presented with 24 faces -- the 12 that they had viewed in the first part of the test, and 12 new faces -- and asked to identify the faces they had seen in the face learning phase.

Good lookers

It turned out that the super-recognisers were more accurate than typical recognisers whether the size of the aperture was large or very small. While there didn't seem to be a pattern in the features that super-recognisers gazed at compared to typical recognisers, there was a difference in the time that they spent looking at the eyes.

"We found that they actually look at the eyes less. This is despite the fact that a lot of research has been saying that looking at the eyes is such an important part of recognition and that the eyes do contain visual information that can give away a person's identity.

"So this was a bit of a mystery. One theory we have is that looking away from the eyes creates the opportunity to extract identity information from other features."

The researchers said their experiment changes the way we think about why some people are better than others at committing a face to memory.

"We think one of the things they're doing uniquely is exploring the face more to find information that is useful for remembering or recognising a person later. So when super-recognisers learn a face, it is more like putting together pieces in a jigsaw puzzle than taking a single snapshot of the whole face."

Other superpowers?

So are super-recognisers good at other tasks, like matching patterns, remembering phone numbers, or having photographic memories?

While that wasn't a subject of this particular study, Dr Dunn said that in another study recently published in Psychonomic Bulletin & Reviewthey found that those who are good at comparing images of people's faces -- like comparing someone's face to their driver's licence photo -- may also be good at comparing other types of visual patterns.

"We are starting to find evidence from super-recognisers and the public that people who were accurate when matching photographs of faces also tended to be more accurate matching other types of visual patterns, like the fingerprint and firearm samples that are analysed by forensic scientists.

"This leads us to believe that there is a general ability to compare complex visual patterns that is shared across different objects, which means that the same skills that make someone good at matching faces may also help you compare these other patterns as well," he said.

Looking ahead, Dr Dunn and his fellow researchers are keen to take super-recognising out of the lab and into the real world. They plan to have super-recognisers wear special eye-tracking glasses that record what their eyes are doing as they move about in the world and interact with people.

"We'd like to see whether some of the things we've observed in the lab about how super-recognisers learn and remember faces are the same in their day-to-day life."

The super-recognisers who were part of the study were selected after performing strongly in the online UNSW Face Test.

https://www.sciencedaily.com/releases/2022/08/220831113609.htm

Your blood type could predict your risk of having a stroke before age 60

Research could lead to potential new ways to predict and prevent strokes in young adults

August 31, 2022

Science Daily/University of Maryland School of Medicine

A person's blood type may be linked to their risk of having an early stroke, according to a new meta-analysis led by University of Maryland School of Medicine (UMSOM) researchers. Findings were published today in the journal Neurology. The meta-analysis included all available data from genetic studies focusing on ischemic strokes, which are caused by a blockage of blood flow to the brain, occurring in younger adults under age 60.

"The number of people with early strokes is rising. These people are more likely to die from the life-threatening event, and survivors potentially face decades with disability. Despite this, there is little research on the causes of early strokes," said study co-principal investigator Steven J. Kittner, MD, MPH, Professor of Neurology at UMSOM and a neurologist with the University of Maryland Medical Center.

He and his colleagues conducted the study by performing a meta-analysis of 48 studies on genetics and ischemic stroke that included 17,000 stroke patients and nearly 600,000 healthy controls who never had experienced a stroke. They then looked across all collected chromosomes to identify genetic variants associated with a stroke and found a link between early-onset stroke -- occurring before age 60 -- and the area of the chromosome that includes the gene that determines whether a blood type is A, AB, B, or O.

The study found that people with early stroke were more likely to have blood type A and less likely to have blood type O (the most common blood type) -- compared to people with late stroke and people who never had a stroke. Both early and late stroke were also more likely to have blood type B compared to controls. After adjusting for sex and other factors, researchers found those who had blood type A had a 16 percent higher risk of having an early stroke than people with other blood types. Those who had blood type O had a 12 percent lower risk of having a stroke than people with other blood types.

"Our meta-analysis looked at people's genetic profiles and found associations between blood type and risk of early-onset stroke. The association of blood type with later-onset stroke was much weaker than what we found with early stroke," said study co-principal investigator Braxton D. Mitchell, PhD, MPH, Professor of Medicine at UMSOM.

The researchers emphasized that the increased risk was very modest and that those with type A blood should not worry about having an early-onset stroke or engage in extra screening or medical testing based on this finding.

"We still don't know why blood type A would confer a higher risk, but it likely has something to do with blood-clotting factors like platelets and cells that line the blood vessels as well as other circulating proteins, all of which play a role in the development of blood clots," said Dr. Kittner. Previous studies suggest that those with an A blood type have a slightly higher risk of developing blood clots in the legs known as deep vein thrombosis. "We clearly need more follow-up studies to clarify the mechanisms of increased stroke risk,"he added.

In addition to Dr. Kittner and Dr. Mitchell, UMSOM faculty involved in this study included Huichun Xu, MD, PhD, Associate Professor of Medicine; Patrick F. McArdle, PhD, Associate Professor of Medicine; Timothy O'Connor, PhD, Associate Professor of Medicine; James A. Perry, PhD, Assistant Professor of Medicine; Kathleen A. Ryan, MPH, MS, Statistician; John W. Cole, MD, Professor of Neurology; Marc C. Hochberg, MD, MPH, Professor of Medicine; O. Colin Stine, PhD, Professor of Epidemiology and Public Health; and Charles C. Hong, MD, PhD, Melvin Sharoky MD Professor of Medicine.

A limitation of the study was the relative lack of diversity among participants. The data was derived from the Early Onset Stroke Consortium, a collaboration of 48 different studies across North America, Europe, Japan, Pakistan, and Australia. About 35 percent of the participants were of non-European ancestry.

"This study raises an important question that requires a deeper investigation into how our genetically predetermined blood type may play a role in early stroke risk," said Mark T. Gladwin, MD, Executive Vice President for Medical Affairs, UM Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine. "It points to the urgent need to find new ways to prevent these potentially devastating events in younger adults."

The study was supported by the National Institutes of Health and Department of Veterans Affairs. Researchers from more than 50 institutions worldwide were co-authors on this study.

https://www.sciencedaily.com/releases/2022/08/220831162509.htm

Cannabis legalization boosts use by double digits

A first-of-its kind study of twins finds those who live in states where marijuana is legal use it 24% more

August 27, 2022

Science Daily/University of Colorado at Boulder

Residents of states where cannabis has been legalized use marijuana 24% more frequently than those living in states where it remains illegal, according to new research published today in the journal Addiction.

The study of more than 3,400 adult twins, by researchers at University of Minnesota and University of Colorado, constitutes some of the strongest evidence yet that legalization causes increased use.

It comes at a time when cannabis use is rising nationwide, including during adulthood -- a phase of life when individuals have historically tended to cut back.

"Across America, there is a trend toward using more marijuana but we found that the change is bigger in states where it is legal," said lead author Stephanie Zellers, a recent University of Minnesota graduate who began the research while a PhD student at CU Boulder's Institute for Behavioral Genetics (IBG).

For the study, Zellers and co-authors at CU Boulder, CU Anschutz Medical Campus and University of Minnesota analyzed data from two large longitudinal twin studies, which have tracked twins since childhood in both states: one housed at IBG and another at the Minnesota Center for Twin Family Research.

Participants were asked how frequently they used cannabis before and after 2014 when Colorado became one of the first states to commence legal sales of recreational marijuana. Recreational cannabis remains illegal in Minnesota. Before 2014, there was little difference in use between states, the study found. After 2014, across all participants, residents of states where recreational use of marijuana was legalized used cannabis 24% more frequently than those in illegal states.

When specifically comparing identical twins in which one now lives in a state where marijuana is legal and the other lives in a state where it is illegal, those living in the state with legal marijuana used cannabis 20% more frequently, the researchers found.

Because twins share their genes and tend to share socioeconomic status, parental influences and community norms, they provide well-matched controls for each other, enabling researchers to minimize alternative explanations for results and get at what causes what.

"This is the first study to confirm that the association between legal cannabis and increased use holds within families in genetically identical individuals," said co-author John Hewitt, a professor in the Department of Psychology and Neuroscience and faculty fellow at IBG. "This makes it much more likely that legalization does, in itself, result in increased use."

More than 141 million Americans now live in a state with recreationally legal cannabis and, according to the National Institute on Drug Abuse, use among young adults age 19 to 30 is at an all-time high, with 43% reporting use in the past year and 29% in the last month.

"Typically, what we would expect to see is that people tend to increase use as adolescents and then reduce it as they transition into adult roles, family life and stable jobs," said Zellers. "Interestingly, we saw escalation, not reduction, in adults."

The authors note that it is unlikely that legalization would cause those who abstained from marijuana before to pick up the habit.

And preliminary results from their broader ongoing research project suggest increased use may not necessarily be a bad thing.

"In other analyses, we are finding that this increased use is not accompanied by increased problems, may be associated with less alcohol-related problems, and otherwise does not, in general, seem to have adverse consequences," said Hewitt.

https://www.sciencedaily.com/releases/2022/08/220827092455.htm

Psychedelics may lessen fear of death and dying, similar to feelings reported by those who've had near death experiences

August 24, 2022

Science Daily/Johns Hopkins Medicine

In a survey study of more than 3,000 adults, Johns Hopkins Medicine researchers compared psychedelic experiences with near-death experiences that were not drug related and found notable similarities in people's attitudes toward death. Survey participants in both groups reported having less fear of death and dying after the experience. They also reported that the experience had a lasting positive effect, providing personal meaning, spiritual significance and psychological insight.

The study was published Aug. 24, 2022 in the journal PLOS ONE.

The results are consistent with several recent clinical trials showing that a single treatment with the psychedelic psilocybin produced sustained decreases in anxiety and depression among patients with a life-threatening cancer diagnosis. The largest of these trials (Griffiths et al., 2016) was conducted at Johns Hopkins Medicine by the authors of this survey. That study, a randomized trial of 51 patients with cancer who had clinically significant anxiety or depressive symptoms, demonstrated that receiving a controlled, high dose of psilocybin given with supportive psychotherapy resulted in significant increases in ratings of death acceptance, as well as decreases in anxiety about death.

For the present study, the researchers analyzed data gathered from 3,192 people who answered an online survey between December 2015 and April 2018. Participants were divided into groups: 933 individuals had non-drug-related near-death experiences, and the rest of the participants had psychedelic experiences, which were prompted by either lysergic acid diethylamide (LSD) (904), psilocybin (766), ayahuasca (282) or N,N-dimethyltryptamine (DMT) (307). Participants were predominantly white (85%) and mostly from the United States. Compared with the non-drug group, there were more men in the psychedelic group (78% versus 32%), and they tended to be younger (32 versus 55 years of age) at the time of the experience.

Similarities between the groups include:

• About 90% of participants in both groups reported a decrease in fear of death when considering changes in their views from before to after the experience.

• Most participants in both groups (non-drug group, 85%; psychedelics group, 75%) rated the experience to be among the top five most personally meaningful and spiritually significant of their life.

• Participants in both groups reported moderate to strong persisting positive changes in personal well-being and life purpose and meaning.

Differences between the groups include:

• The non-drug group was more likely to report that their life was in danger (47% versus the psychedelics group, 3%), being medically unconscious (36% versus the psychedelics group, 10%), or being clinically dead (21% versus the psychedelics group, less than 1%).

• The non-drug group was more likely to report that their experience was very brief, lasting five minutes or less (40% versus the psychedelics group, 7%).

The researchers say that future studies are needed to better understand the potential clinical use of psychedelics in ameliorating suffering related to fear of death.

https://www.sciencedaily.com/releases/2022/08/220824152209.htm