Is TBI a chronic condition?

Study finds function may improve, decline up to seven years after injury

June 21, 2023

Science Daily/American Academy of Neurology

People with TBI may continue to improve or decline years after their injury, making it a more chronic illness, according to a study published in the June 21, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

"Our results dispute the notion that TBI is a one-time event with a stagnant outcome after a short period of recovery," said study author Benjamin L. Brett, PhD, of the Medical College of Wisconsin in Milwaukee. "Rather, people with TBI continue to show improvement and decline across a range of areas including their ability to function and their thinking skills."

The study involved people at 18 level 1 trauma center hospitals with an average age of 41. A total of 917 people had mild TBI and 193 people had moderate to severe TBI. They were matched to 154 people with orthopedic injuries but no head injuries. Participants were followed for up to seven years.

Participants took three tests on thinking, memory, mental health and ability to function with daily activities annually from two to seven years post-injury. They also completed an interview on their abilities and symptoms, including headache, fatigue, and sleep disturbances.

When researchers looked at all test scores combined, 21% of people with mild TBI experienced decline, compared to 26% of people with moderate to severe TBI and 15% of people with orthopedic injuries with no head injury.

Among the three tests, researchers saw the most decline over the years in the ability to function with daily activities. On average, over the course of 2 to 7 years post-injury, a total of 29% of those with mild TBI declined in their abilities and 23% of those with moderate to severe TBI.

Yet some people showed improvement in the same area, with 22% of those with mild TBI improving over time and 36% of those with moderate to severe TBI.

"These findings point out the need to recognize TBI as a chronic condition in order to establish adequate care that supports the evolving needs of people with this condition," Brett said. "This type of care should place a greater emphasis on helping people who have shown improvement continue to improve and implementing greater levels of support for those who have shown decline."

A limitation of the study was that all participants were seen at a level 1 trauma center hospital within 24 hours of their injury, so the findings may not apply to other populations.

The study was funded by the National Institute of Neurological Disorders and Stroke, National Institute on Aging, the National Football League Scientific Advisory Board and the U.S. Department of Defense.

https://www.sciencedaily.com/releases/2023/06/230621164720.htm

Everyone's brain has a pain fingerprint -- new research has revealed for the first time

June 20, 2023

Science Daily/University of Essex

 New research has revealed everyone's brain has a 'pain fingerprint' that varies from person to person.

The University of Essex-led study, in collaboration with the neuroscience of pain group at the Ludwig Maximilians University of Munich, found fast-oscillating brain waves linked to brief pain and touch can differ widely in scans.

These waves, called gamma oscillations, were previously thought to represent pain perception in the brain -- with past research focussing on group data and overlooking individual differences, even discarding them as 'noise' in scans.

The Department of Psychology's Dr Elia Valentini found major differences in timing, frequency and location of the gamma oscillations and incredibly some people showed no waves at all.

Dr Valentini said: "Not only, for the first time, can we pinpoint the extreme variability in the gamma response across individuals, but we also show that the individual response pattern is stable across time."

"This pattern of group variability and individual stability may apply to other brain responses, and characterising it may allow us to identify individual pain fingerprints in the activity of the brain."

The study, published in the Journal of Neurophysiology, was able to map patterns in participants from another lab, suggesting a replicable phenomenon.

In total, data from 70 people were examined. The experiments were split into two studies with a laser used to generate pain.

Overall, it was discovered that the subject's gamma waves were "remarkably stable" and created similar individual patterns when stimulated.

Interestingly, some recorded feeling pain and having no gamma response, whilst others had a large response.

At this stage, it is not known why there is such variation -- but it is hoped this will be a springboard for future research.

Dr Valentini added: "I think we need to go back to square one because past findings on the relationship between pain and gamma oscillations do not represent all the participants.

"Unfortunately, this minority can drive the research results and lead to misleading conclusions about the functional significance of these responses.

"We don't mean for gamma oscillations not to have a role in pain perception, but we certainly won't find its true role if we keep quantifying it as we did thus far."

Dr Valentini hopes this study will also change the way gamma oscillations are measured in other sensory domains.

https://www.sciencedaily.com/releases/2023/06/230620113739.htm

Walkable neighborhoods help adults socialize, increase community

June 20, 2023

Science Daily/University of California - San Diego

Adults who live in walkable neighborhoods are more likely to interact with their neighbors and have a stronger sense of community than people who live in car-dependent communities, report researchers at the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego.

The findings of the study, published online in the journal Health & Place, support one of six foundational pillars suggested by United States Surgeon General Vivek Murthy as part of a national strategy to address a public health crisis caused by loneliness, isolation and lack of connection in this country.

In May 2023, the Surgeon General Advisory stated that loneliness and isolation can lead to a 29% increased risk of heart disease, a 32% increased risk of stroke, a 50% increased risk of developing dementia among older adults, and increases risk of premature death by more than 60%.

To address this public health crisis, the Surgeon General recommends strengthening social infrastructure by designing environments that promote connection.

"Our built environments create or deny long-lasting opportunities for socialization, physical activity, contact with nature, and other experiences that affect public health," said James F. Sallis, Ph.D., Distinguished Professor at the Herbert Wertheim School of Public Health and senior author of the UC San Diego study.

"Transportation and land use policies across the U.S. have strongly prioritized car travel and suburban development, so millions of Americans live in neighborhoods where they must drive everywhere, usually alone, and have little or no chance to interact with their neighbors."

Walkable neighborhoods promote active behaviors like walking for leisure or transportation to school, work, shopping or home.

The study analyzed data from the Neighborhood Quality of Life Study, which included 1,745 adults ages 20 to 66 living in 32 neighborhoods located in and around Seattle, Baltimore and Washington, D.C.

Neighborhood walkability may promote social interactions with neighbors -- like waving hello, asking for help or socializing in their homes, said the first author, Jacob R. Carson, M.P.H., a student in the UC San Diego -- San Diego State University Joint Doctoral Program in Public Health. Carson began the research while a Master of Public Health student at the Herbert Wertheim School of Public Health.

Neighborhoods where people must drive in and out, and where there is an absence of gathering places, may have the opposite effect, preventing neighbors from socializing.

"Promoting social interaction is an important public health goal. Understanding the role of neighborhood design bolsters our ability to advocate for the health of our communities and the individuals who reside in them," said Carson.

"Fewer traffic incidents, increases in physical activity, and better neighborhood social health outcomes are just a few of the results of designing walkable neighborhoods that can enrich our lives."

https://www.sciencedaily.com/releases/2023/06/230620113745.htm

New research reveals the impact of different species and their traits on human wellbeing

June 20, 2023

Science Daily/University of Kent

New research has revealed for the first time that well-functioning ecosystems are crucial to human health and wellbeing, with human-biodiversity interactions delivering wellbeing gains equating to substantial healthcare cost-savings, when scaled-up across populations.

The University of Kent-led study, which is part of the European Research Council-funded project 'Relating Subjective Wellbeing to Biodiversity' (RELATE), set out to understand which components of nature and biodiversity played a particular role in human wellbeing.

The team, which was led by Kent's Professor Zoe Davies, analysed the effects of species' traits, based on people's feedback following a series of workshops, to identify those that generate different types of wellbeing e.g., physical, emotional, cognitive, social, spiritual, and 'global', the latter being akin to 'whole-person health'.

The team found that, in general, the vast majority of species and traits are beneficial to human wellbeing. They also discovered that each species may support multiple traits, potentially with different impacts. For example, the colours of brambles (black, pink, red) are linked to multiple positive physical, emotional and social wellbeing types, but their prickly texture generated negative emotional wellbeing. The numerous traits from across an ecological community can elicit a multitude of wellbeing responses, illustrating the true complexity of how people relate to biodiversity.

Professor Davies, a biodiversity conservationist at Kent's Durrell Institute of Conservation and Ecology (DICE), said: 'While we know that spending time in natural environments can improve our health and wellbeing, we still need to know more about which species, or traits of species (such as colours, sounds, smells, textures and behaviours), deliver these benefits -- and how people's relationships with biodiversity are both contextually and culturally specific. Understanding how people experience biodiversity is therefore key to successfully managing biodiversity to facilitate human wellbeing.'

Study co-author, Professor Martin Dallimer, from the School of Earth and Environment, University of Leeds, said: 'For the first time, through analysing people's own words and reflections, we are able to explicitly link that feeling of wellbeing with species and their traits. How people respond to biodiversity is hugely varied and if we want people's wellbeing to benefit from spending time in nature, then it is essential to make sure we are maintaining and restoring high quality biodiverse spaces for wildlife and for people. Our aim is that these findings really drive home how important biodiversity is in underpinning wellbeing benefits, particularly to healthcare and public sectors who include 'spending time in nature' as an element of mental health and wellbeing.'

Dr Jessica Fisher, also from DICE, added: 'By starting to comprehend how people experience biodiversity, we can begin to manage our natural environments for both biodiversity conservation and human health. Even small improvements in wellbeing at an individual level could scale up to substantial healthcare cost savings across an entire country. Our approach can be used to create better-tailored public health interventions or architectural/landscape designs by, for example, maximising the likelihood of people having interactions with certain species and their traits. Critically, as each additional species in an ecological community supports additional traits, maintaining or enhancing biodiversity will be key to delivering human wellbeing.'

https://www.sciencedaily.com/releases/2023/06/230620113805.htm

Regular napping linked to larger brain volume

Daytime napping may help to preserve brain health by slowing the rate at which our brains shrink as we age

June 20, 2023

Science Daily/University College London

A study analyzed data from people aged 40 to 69 and found a causal link between habitual napping and larger total brain volume -- a marker of good brain health linked to a lower risk of dementia and other diseases.

Daytime napping may help to preserve brain health by slowing the rate at which our brains shrink as we age, suggests a new study led by researchers at UCL and the University of the Republic in Uruguay.

The study, published in the journal Sleep Health, analysed data from people aged 40 to 69 and found a causal link between habitual napping and larger total brain volume -- a marker of good brain health linked to a lower risk of dementia and other diseases.

Senior author Dr Victoria Garfield (MRC Unit for Lifelong Health & Ageing at UCL) said: "Our findings suggest that, for some people, short daytime naps may be a part of the puzzle that could help preserve the health of the brain as we get older."

Previous research has shown that napping has cognitive benefits, with people who have had a short nap performing better in cognitive tests in the hours afterwards than counterparts who did not nap.

The new study aimed to establish if there was a causal relationship between daytime napping and brain health.

Using a technique called Mendelian randomisation, they looked at 97 snippets of DNA thought to determine people's likelihood of habitual napping. They compared measures of brain health and cognition of people who are more genetically "programmed" to nap with counterparts who did not have these genetic variants, using data from 378,932 people from the UK Biobank study, and found that, overall, people predetermined to nap had a larger total brain volume.

The research team estimated that the average difference in brain volume between people programmed to be habitual nappers and those who were not was equivalent to 2.6 to 6.5 years of ageing.

But the researchers did not find a difference in how well those programmed to be habitual nappers performed on three other measures of brain health and cognitive function -- hippocampal volume, reaction time and visual processing.

Lead author and PhD candidate Valentina Paz (University of the Republic (Uruguay) and MRC Unit for Lifelong Health & Ageing at UCL) said: "This is the first study to attempt to untangle the causal relationship between habitual daytime napping and cognitive and structural brain outcomes. By looking at genes set at birth, Mendelian randomisation avoids confounding factors occurring throughout life that may influence associations between napping and health outcomes. Our study points to a causal link between habitual napping and larger total brain volume."

Dr Garfield added: "I hope studies such as this one showing the health benefits of short naps can help to reduce any stigma that still exists around daytime napping."

The genetic variants influencing our likelihood to nap were identified in an earlier study looking at data from 452,633 UK Biobank participants. The study, led by Dr Hassan Dashti (Harvard University and Massachusetts General Hospital), also an author on the new study, identified the variants on the basis of self-reported napping, and this was supported by objective measurements of physical activity recorded by a wrist-worn accelerometer.

In the new study, researchers analysed health and cognition outcomes for people with these genetic variants as well as several different subsets of these variants, adjusted to avoid potential bias, for instance avoiding variants linked to excessive daytime sleepiness.

Genetic data and magnetic resonance imaging (MRI) scans of the brain were available for 35,080 individuals drawn from the larger UK Biobank sample.

In terms of study limitations, the authors noted that all of the participants were of white European ancestry, so the findings might not be immediately generalisable to other ethnicities.

While the researchers did not have information on nap duration, earlier studies suggest that naps of 30 minutes or less provide the best short-term cognitive benefits, and napping earlier in the day is less likely to disrupt night-time sleep.

Previous research looking at the UK and the Netherlands found that nearly a third of adults aged 65 or over had a regular nap.

https://www.sciencedaily.com/releases/2023/06/230620113759.htm

Study finds combustion from gas stoves can raise indoor levels of chemical linked to a higher risk of blood cell cancers

June 16, 2023

Science Daily/Stanford University

About 47 million homes use natural gas or propane-burning cooktops and ovens. Researchers found that cooking with gas stoves can raise indoor levels of the carcinogen benzene above those found in secondhand smoke.

A chemical linked to a higher risk of leukemia and other blood cell cancers creeps into millions of homes whenever residents light their gas stoves. A new Stanford-led analysis finds that a single gas cooktop burner on high or a gas oven set to 350 degrees Fahrenheit can raise indoor levels of the carcinogen benzene above those in secondhand tobacco smoke. Benzene also drifts throughout a home and lingers for hours in home air, according to the paper published June 22 in Environmental Science & Technology.

"Benzene forms in flames and other high-temperature environments, such as the flares found in oil fields and refineries. We now know that benzene also forms in the flames of gas stoves in our homes," said study senior author Rob Jackson, the Michelle and Kevin Douglas Provostial Professor and professor of Earth system science at the Stanford Doerr School of Sustainability. "Good ventilation helps reduce pollutant concentrations, but we found that exhaust fans were often ineffective at eliminating benzene exposure."

Worse than secondhand smoke

Overall, the researchers found that indoor concentrations of benzene formed in the flames of gas stoves can be worse than average concentrations from secondhand smoke, that benzene can migrate into other rooms far from the kitchen, and that concentrations measured in bedrooms can exceed national and international health benchmarks. They also found residential range hoods are not always effective at reducing concentrations of benzene and other pollutants, even when the hoods vent outdoors.

The new paper is the first to analyze benzene emissions when a stove or oven is in use. Previous studies focused on leaks from stoves when they are off, and did not directly measure resulting benzene concentrations. The researchers found gas and propane burners and ovens emitted 10 to 50 times more benzene than electric stoves. Induction cooktops emitted no detectable benzene whatsoever. The rates of benzene emitted during combustion were hundreds of times higher than benzene emission rates identified in other recent studies from unburned gas leaking into homes.

The researchers also tested whether foods being cooked emit benzene and found zero benzene emissions from pan-frying salmon or bacon. All benzene emissions the investigators measured came from the fuel used rather than any food cooked.

A previous Stanford-led study showed that gas-burning stoves inside U.S. homes leak methane with a climate impact comparable to the carbon dioxide emissions from about 500,000 gasoline-powered cars. They also expose users to pollutants, such as nitrogen dioxide, which can trigger respiratory diseases. A 2013 meta-analysis concluded that children who live in homes with gas stoves had a 42% greater risk of asthma than children living in homes without gas stoves, and a 2022 analysis calculated that 12.7% of childhood asthma in the U.S. is attributable to gas stoves.

"I'm renting an apartment that happens to have an electric stove," said study lead Yannai Kashtan, a graduate student in Earth system science. "Before starting this research, I never thought about it twice, but the more we learn about pollution from gas stoves, the more relieved I am to be living without a gas stove."

Jackson is also a senior fellow at the Stanford Woods Institute for the Environment and the Precourt Institute for Energy. Study co-authors also include Metta Nicholson and Colin Finnegan, environmental science research professionals in Stanford's Earth System Science Department; Zutao Ouyang, a physical science research associate in Stanford's Earth System Science Department; and researchers at PSE Healthy Energy, the University of California, Berkeley, and Lawrence Berkeley National Lab.

The study was funded by the High Tide Foundation.

How to reduce exposure to pollutants from gas stoves

Beyond ensuring proper ventilation with a range hood or open window, relatively low-cost approaches to reducing exposure to pollutants from gas stoves include:

• Use portable induction cooktops, which can be found for less than $50 new.

• Use electric kitchenware, such as tea kettles, toaster ovens, and slow cookers.

• Where available, take advantage of state and local rebates as well as low- or no-interest loans (such as these programs for California and the San Francisco Bay Area) to offset the cost of replacing gas appliances.

• Federal tax credits are available now, and federal rebates should be available later this year or sometime in 2024 to help offset the cost of replacing gas appliances.

https://www.sciencedaily.com/releases/2023/06/230616161910.htm

Dads are key in supporting breastfeeding, safe infant sleep

Including fathers in strategies to improve infant health could help narrow disparities

June 16, 2023

Science Daily/Northwestern University

Fathers can make a huge difference in whether an infant is breastfed and placed to sleep safely, according to a recent survey of new fathers led by scientists at Northwestern University and the Ann & Robert H. Lurie Children's Hospital of Chicago.

The study included 250 fathers who were surveyed two to six months after the birth of their infant. The survey findings are among the first to describe father-reported attitudes toward and experiences with breastfeeding and infant sleep practices in a state-representative sample. They will be published June 16 in the journal Pediatrics.

Among fathers who wanted their infant's mother to breastfeed, 95% reported breastfeeding initiation and 78% reported breastfeeding at eight weeks. This is significantly higher than the rates reported by fathers who had no opinion or did not want their infant's mother to breastfeed -- 69% of these fathers reported breastfeeding initiation and 33% reported breastfeeding at eight weeks.

The scientists also found that 99% of fathers reported placing their infant to sleep, but only 16% implemented all three American Academy of Pediatrics-recommended infant sleep practices (using the back sleep position, an approved sleep surface, and avoiding soft bedding). Almost a third of fathers surveyed were missing at least one key component of safe sleep education.

"Our findings underscore that new fathers are a critical audience to promote breastfeeding and safe infant sleep," said lead study author Dr. John James Parker, an instructor of pediatrics at Northwestern University Feinberg School of Medicine, pediatrician at Lurie Children's and an internist at Northwestern Medicine. "Many families do not gain the health benefits from breastfeeding because they are not provided the support to breastfeed successfully. Fathers need to be directly engaged in breastfeeding discussions, and providers need to describe the important role fathers play in breastfeeding success."

Racial disparities in rates of SIDS in the U.S. 

Black fathers were less likely to use the back sleep position and more likely to use soft bedding than white fathers. More than 3,000 infants die of sleep-related deaths per year in the U.S. Nationally, the rate of sudden unexpected infant death (SIDS) of Black infants is more than twice that of white infants, and unsafe sleep practices may contribute to this disparity, the study authors said.

"Fathers need to receive counseling on all the safe sleep practices for their infants," Parker said. "To reduce racial disparities in sudden unexpected infant death, we need tailored strategies to increase safe infant sleep practices in the Black community, including public campaigns to increase awareness and home visiting programs. These interventions must involve both parents to be most effective."

New survey highlights unique needs of new fathers

Recognizing that new dads play an important role in the health and wellbeing of children and families, senior author Dr. Craig Garfield, professor of pediatrics and medical social sciences at Feinberg and a Lurie Children's pediatrician, partnered with the Centers for Disease Control and Prevention (CDC) and the Georgia Department of Public Health to develop and pilot the new survey tool used in this study called Pregnancy Risk Assessment Monitoring System (PRAMS) for Dads.

The tool was modeled after PRAMS, an annual surveillance tool the CDC and public health departments have used for more than 35 years to survey new mothers. PRAMS for Dads is, for the first time, providing data on the unique needs of new fathers. The survey gathers data on the health behaviors and experiences of men as they enter fatherhood.

"As pediatricians, we focus on how to ensure the best health outcomes for children, with successful breastfeeding and safe sleep practices being two key behaviors that impact children's health," said Garfield, who also is the founder of the Family & Child Health Innovations Program (FCHIP) at Lurie Children's. "Our study highlights the fact that fathers play a big role in both these behaviors, but there is more to be done to support fathers."

For example, Garfield said they found that fathers with college degrees were more likely to report that their baby breastfed, and they were more likely to receive guidance on infant sleep safety.

"To improve child health outcomes, we need to make sure breastfeeding and safe sleep guidance reach all new parents equitably," Garfield said.

https://www.sciencedaily.com/releases/2023/06/230616161903.htm

Sports concussions increase injury risk

June 16, 2023

Science Daily/University of South Australia

Concussions are an unfortunate reality of contact sports at junior and senior levels. Now, sports experts at the University of South Australia are suggesting extended recovery times may be needed for youth athletes suffering from head trauma as new research shows a concussion can increase future injury risk by 50%.

Published in the Journal of Science and Medicine in Sport,the world-first study tracked and evaluated the long-term impact of concussion and subsequent injury risk of 1455 sub-elite junior Australian rules football players.

This builds on previous UniSA research that found an approximate 1.5-fold increased risk of injury of sub-elite Australian rules football players returning from an injury, compared to those with no injury.

Tracking injuries over a seven-season period, researchers found that football players who suffered a concussion were also about 1.5 times more likely to be reinjured in the future when compared to players who had never been injured. This increased risk was the same as players returning from upper and lower limb injuries.

The finding comes ahead of the Australian Senate's report into concussion injuries, and follows the AFL's announcement for a $25 million study into the long-term effects of concussions and head knocks.

In the AFL, concussions are one of the most common injuries, with an average of six concussions every 1000 hours played, which involve around 70 to 80 male players every year.

In junior elite football as well as AFL and AFLW, the guidelines for concussion say that the earliest a player can return to play post-concussion is 12 days after the injury, after following the graded progression through a return-to-play program.

Lead researcher, UniSA's Dr Hunter Bennett, says the significant and elevated risk of injury after a concussion may suggest a longer recovery time is required for some players to better recover before returning to play.

"The current recommendation of 12 days post-concussion may not be sufficient to allow full recovery in elite under-18 footballers," Dr Bennett says.

It may also indicate that the physical qualities impacted by concussion should be assessed more thoroughly before an athlete is cleared to return to the sport.

"Concussion is a common injury in Australian rules football that can lead to impairments in balance, coordination, reaction time, and decision making -- and these impairments can increase the risk of other injuries if an athlete returns to play before being fully recovered."

A recent consensus statement on concussion in sport also indicates that children and teenagers may take up to four-weeks to recover from a sport related concussion.

"Concussions are a unique injury that occur without muscle tissue damage, instead impacting aspects of motor control," Dr Bennett says.

"Recurrent injuries can significantly impact team success, player health, and career longevity.

"In elite sports, there is the potential for young athletes to overplay their readiness to return to sport after an injury, as they worry that missing games can exclude them from senior drafting or competition.

"When we know that athletes have a greater risk of another injury post a concussion, it suggests we need unique and careful rehabilitation strategies to monitor when an athlete is fully recovered and ready to return to play."

Researchers say that future research should seek to identify optimal rehabilitation and injury prevention strategies for athletes who suffer from concussions.

https://www.sciencedaily.com/releases/2023/06/230616161943.htm

High-quality child care contributes to later success in science, math

Children with caregivers who provide warmth, cognitive stimulation do better in STEM subjects in high school

June 15, 2023

Science Daily/American Psychological Association

Children who receive high-quality child care as babies, toddlers and preschoolers do better in science, technology, engineering and math through high school, and that link is stronger among children from low-income backgrounds, according to research published by the American Psychological Association.

"Our results suggest that caregiving quality in early childhood can build a strong foundation for a trajectory of STEM success," said study author Andres S. Bustamante, PhD, of the University of California Irvine. "Investing in quality child care and early childhood education could help remedy the underrepresentation of racially and ethnically diverse populations in STEM fields."

The research was published in the journal Developmental Psychology.

Many studies have demonstrated that higher quality caregiving in early childhood is associated with better school readiness for young children from low-income families. But not as many have looked at how the effects of early child care extend into high school, and even fewer have focused specifically on STEM subjects, according to Bustamante.

To investigate those questions, Bustamante and his colleagues examined data from 979 families who participated in the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, from the time of the child's birth in 1991 until 2006.

As part of the study, trained observers visited the day cares and preschools of all the children who were enrolled for 10 or more hours per week. The observers visited when the children were 6, 15, 24, 36 and 54 months old, and rated two aspects of the child care: the extent to which the caregivers provided a warm and supportive environment and responded to children's interests and emotions, and the amount of cognitive stimulation they provided through using rich language, asking questions to probe the children's thinking, and providing feedback to deepen the children's understanding of concepts.

The researchers then looked at how the students performed in STEM subjects in elementary and high school. To measure STEM success, they examined the children's scores on the math and reasoning portions of a standardized test in grades three to five. To measure high school achievement, the researchers looked at standardized test scores and the students' most advanced science course completed, the most advanced math course completed, GPA in science courses and GPA in math courses.

Overall, they found that both aspects of caregiving quality (more cognitive stimulation and better caregiver sensitivity-responsivity) predicted greater STEM achievement in late elementary school (third, fourth and fifth grade), which in turn predicted greater STEM achievement in high school at age 15. Sensitive and responsive caregiving in early childhood was a stronger predictor of high school STEM performance for children from low-income families compared with children from higher income families.

"Our hypothesis was that cognitive stimulation would be more strongly related to STEM outcomes because those kinds of interactions provide the foundation for exploration and inquiry, which are key in STEM learning," Bustamante said. "However, what we saw was that the caregiver sensitivity and responsiveness was just as predictive of later STEM outcomes, highlighting the importance of children's social emotional development and settings that support cognitive and social emotional skills."

Overall, Bustamante said, research and theory suggest that high-quality early care practices support a strong foundation for science learning. "Together, these results highlight caregiver cognitive stimulation and sensitivity and responsiveness in early childhood as an area for investment to strengthen the STEM pipeline, particularly for children from low-income households."

https://www.sciencedaily.com/releases/2023/06/230615105245.htm

Cutting back on social media reduces anxiety, depression, loneliness

June 14, 2023

Science Daily/Iowa State University

Researchers found college students who tried to cut their social media use to 30 minutes per day scored significantly lower for anxiety, depression, loneliness and fear of missing out at the end of the two-week experiment and when compared to the control group.

Last month, the American Psychological Association and the U.S. Surgeon General both issued health advisories. Their concerns and recommendations for teens, parents and policymakers addressed a mounting body of research that shows two trends are intertwined.

Young people are using social media more, and their mental health is suffering.

Researchers at Iowa State University found a simple intervention could help. During a two-week experiment with 230 college students, half were asked to limit their social media usage to 30 minutes a day and received automated, daily reminders. They scored significantly lower for anxiety, depression, loneliness and fear of missing out at the end of the experiment compared to the control group.

They also scored higher for "positive affect," which the researchers describe as "the tendency to experience positive emotions described with words such as 'excited' and 'proud.'" Essentially, they had a brighter outlook on life.

"It surprised me to find that participants' well-being did not only improve in one dimension but in all of them. I was excited to learn that such a simple intervention of sending a daily reminder can motivate people to change their behavior and improve their social media habits." says Ella Faulhaber, a Ph.D. student in human-computer interaction and lead author of the paper.

The researchers found the psychological benefits from cutting back on social media extended to participants who sometimes exceeded the 30-minute time limit.

"The lesson here is, it's not about being perfect but putting in effort, which makes a difference. I think self-limiting and paying attention are the secret ingredients, more so than the 30-minute benchmark," Faulhaber states.

Douglas A. Gentile, co-author and distinguished professor of psychology, says their results fit with other research that's grown out of kinesiology and health fields.

"Knowing how much time we spend on activities each day and making something countable makes it easier for people to change their behaviors," he says, giving Fitbits and daily steps as an example.

Many of the participants in the ISU study commented that the first few days of cutting back were challenging. But after the initial push, one said they felt more productive and in tune with their lives. Others shared that they were getting better sleep or spending more time with people in person.

Self-limiting may be more practical

Gentile and Faulhaber point out other studies have investigated the effects of limiting or abstaining from social media. But many of the interventions require heavy supervision and deleting apps or using a special application to block or limit social media. Like rehab for someone who's addicted to drugs, external accountability can help some users. But it also carries a higher risk of backfiring.

"When a perceived freedom is taken away, we start resisting," says Gentile. He adds that eliminating social media also means losing some of the benefits it can bring, like connecting with friends and family.

Faulhaber says their study extends the current research on social media and provides a practical way for people to limit their use. For anyone looking to cut back, she recommends:

1. Create awareness. Set a timer or use a built-in wellness app to see how much time you spend on social media.

2. Give yourself grace. Recognize that it's not easy to stick to a time limit. Social media apps are designed to keep you engaged.

3. Don't give up. Limiting social media use over time has real benefits for your daily life.

The researchers say it's also important to be mindful of how and when we use these platforms. Future research could further explore this, along with the long-term effects from limiting social media and what people do with the time they gain.

"We live in an age of anxiety. Lots of indicators show that anxiety, depression, loneliness are all getting worse, and that can make us feel helpless. But there are things we can do to manage our mental health and well-being," says Gentile.

Paying more attention to how much time we spend on social media and setting measurable goals can help.

https://www.sciencedaily.com/releases/2023/06/230614220707.htm

Psychedelic drugs reopen 'critical periods' for social learning

June 14, 2023

Science Daily/Johns Hopkins Medicine

Neuroscientists have long searched for ways to reopen "critical periods" in the brain, when mammals are more sensitive to signals from their surroundings that can influence periods of brain development. Now, researchers at Johns Hopkins Medicine say a new study in mice shows that psychedelic drugs are linked by their common ability to reopen such critical periods, but differ in the length of time the critical period is open -- from two days to four weeks with a single dose.

The findings, published June 16 in the journal Nature, provide a new explanation for how psychedelic drugs work, say the scientists, and suggest potential to treat a wider range of conditions, such as stroke and deafness, beyond those in current studies of the drugs, such as depression, addiction and post-traumatic stress disorder. The scientists also provide a new look at molecular mechanisms impacted by psychedelics.

Critical periods have been demonstrated to perform such functions as help birds learn to sing and help humans learn a new language, relearn motor skills after a stroke and establish dominance of one eye over the other eye.

"There is a window of time when the mammalian brain is far more susceptible and open to learning from the environment," says Gül Dölen, M.D., Ph.D., associate professor of neuroscience at the Johns Hopkins University School of Medicine. "This window will close at some point, and then, the brain becomes much less open to new learning."

Building on her laboratory's experience studying social behavior, Dölen's team has been researching how psychedelic drugs work by reopening these critical periods. In 2019, her team found that MDMA, a psychedelic drug that arouses feelings of love and sociability, opens a critical period in mice.

At the time, Dölen thought MDMA's prosocial properties smooth the way for opening the critical period, but her team was surprised, she says, to find in the current study that other psychedelic drugs without prosocial properties could also reopen critical periods.

For the current study, Dölen's team looked at the reopening potential of five psychedelic drugs -- ibogaine, ketamine, LSD, MDMA and psylocibin -- shown in numerous studies as able to change normal perceptions of existence and enable a sense of discovery about one's self or the world.

The research team conducted a well-established behavioral test to understand how easily adult male mice learn from their social environment. They trained mice to develop an association between an environment linked with social interaction versus another environment connected with being by themselves. By comparing time spent in each environment after giving the psychedelic drug to the mice, the researchers were able to see if the critical period opened in the adult mice, enabling them to learn the value of a social environment -- a behavior normally learned as juveniles.

For mice given ketamine, the critical period of social reward learning stayed open in the mice for 48 hours. With psilocybin, the open state lasted two weeks. For mice given MDMA, LSD and ibogaine, the critical period remained open for two, three and four weeks, respectively.

The researchers say the length of time that the critical period stayed open in mice seems to roughly parallel the average length of time that people self-report the acute effects of each psychedelic drug.

"This relationship gives us another clue that the duration of psychedelic drugs' acute effects may be the reason why each drug may have longer or shorter effects on opening the critical period," says Dölen.

"The open state of the critical period may be an opportunity for a post-treatment integration period to maintain the learning state," she adds. "Too often, after having a procedure or treatment, people go back to their chaotic, busy lives that can be overwhelming. Clinicians may want to consider the time period after a psychedelic drug dose as a time to heal and learn, much like we do for open heart surgery."

Next, the scientists looked at psychedelic drugs' impact on molecular mechanisms. First, in mouse brain cells, they examined a binding point, known as a receptor, for the neurotransmitter serotonin. The researchers found that while LSD and psilocybin use the serotonin receptor to open the critical period, MDMA, ibogaine and ketamine do not.

To explore other molecular mechanisms, the research team turned to ribonucleic acid (RNA), a cousin to DNA that represents which genes are being expressed (producing proteins) in the mice's cells. The researchers found expression differences among 65 protein-producing genes during and after the critical period was opened.

About 20% of these genes regulate proteins involved in maintaining or repairing the extracellular matrix -- a kind of scaffolding that encases brain cells located in the nucleus accumbens, an area associated with social learning behaviors that are responsive to rewards.

https://www.sciencedaily.com/releases/2023/06/230614220630.htm

'Smart' drugs can decrease productivity in people who don't have ADHD

June 14, 2023

Science Daily/University of Cambridge

Research suggests that complex tasks akin to real life decision-making take neurotypical people longer to complete when they take 'smart' drugs than when they do not. The smart drugs do motivate people, but the added effort can lead to 'erratic thinking,' adversely affecting above-average performers.

New research from the University of Cambridge and the University of Melbourne, published in Science Advances, shows neurotypical workers and students taking cognitive enhancers, or 'smart' drugs, may actually be inhibiting their performance and productivity.

Drugs such as methylphenidate, sold under the brand name Ritalin among others, are commonly prescribed for attention deficit hyperactivity disorder (ADHD), but are also taken by those without a diagnosis, in the belief that the drugs will enhance focus and cognitive performance.

In four double-blinded, randomised trials in Melbourne, each a week apart, the same 40 healthy participants took one of three popular 'smart' drugs (methylphenidate, modafinil or dextroamphetamine) or a placebo. They were assessed on how they performed in a test designed to model the complex decision-making and problem-solving present in our everyday lives.

While previous studies into the effects of smart drugs have used simpler cognitive tasks targeting memory or attention, the Melbourne trial involved more computationally complex activities that better simulate the difficult nature of tasks people encounter in daily life.

Participants were asked to complete an exercise known as the Knapsack Optimisation Problem -- or 'knapsack task' -- in which they were given a virtual knapsack with a set capacity, and a selection of items of different weights and values. The participants had to figure out how to best allocate items to the bag, to maximise the overall value of its contents.

Overall, participants taking the drugs saw small decreases in accuracy and efficiency, along with large increases in time and effort, relative to their results when not taking the drugs.

For example, when given methylphenidate -- often used to treat ADHD in children, but increasingly taken by college students cramming for exams -- participants took around 50% longer on average to complete the knapsack problem as when they were given a placebo.

In addition, participants who performed at a higher level in the placebo condition compared to the rest of the group tended to show a bigger decrease in performance and productivity after receiving a drug.

In terms of "productivity," for example -- the level of progress per item moved in or out of the knapsack -- the participants in the top 25% under a placebo regularly ended up in the bottom 25% under methylphenidate.

By contrast, participants who had a lower performance in a placebo condition only very occasionally exhibited a slight improvement after taking a drug.

Professor Peter Bossaerts, Leverhulme International Professor of Neuroeonomics at the University of Cambridge, believes more research needs to be conducted to find out what effects the drugs are having on users without ADHD.

"Our results suggest that these drugs don't actually make you 'smarter'," said Bossaerts. "Because of the dopamine the drugs induce, we expected to see increased motivation, and they do motivate one to try harder. However, we discovered that this exertion caused more erratic thinking -- in ways that we could make precise because the knapsack task had been widely studied in computer science.

"Performance did not generally increase, so questions remain about how the drugs are affecting people's minds and their decision making."

Dr Elizabeth Bowman researcher at the Centre for Brain, Mind and Markets at the University of Melbourne and lead author of the study said the results show we have yet to establish the effectiveness of pharmaceutical enhancers on our performance, when used by neurotypical people to perform everyday complex tasks.

"Our research shows drugs that are expected to improve cognitive performance in patients may actually be leading to healthy users working harder while producing a lower quality of work in a longer amount of time," said Bowman.

https://www.sciencedaily.com/releases/2023/06/230614220559.htm

Altered gut bacteria may be early sign of Alzheimer's disease

Gut microbes of people with pre-symptomatic Alzheimer's differ from those of healthy people

June 14, 2023

Science Daily/Washington University School of Medicine

Alzheimer's disease causes changes to the brain that begin two decades or more before symptoms appear. A study reveals that the bacteria that live in the gut also change before Alzheimer's symptoms arise, a discovery that could lead to diagnostics or treatments for Alzheimer's disease that target the gut microbiome.

People in the earliest stage of Alzheimer's disease -- after brain changes have begun but before cognitive symptoms become apparent -- harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

The findings, published June 14 in Science Translational Medicine, open up the possibility of analyzing the gut bacterial community to identify people at higher risk of developing dementia, and of designing microbiome-altering preventive treatments to stave off cognitive decline.

"We don't yet know whether the gut is influencing the brain or the brain is influencing the gut, but this association is valuable to know in either case," said co-corresponding author Gautam Dantas, PhD, the Conan Professor of Laboratory and Genomic Medicine. "It could be that the changes in the gut microbiome are just a readout of pathological changes in the brain. The other alternative is that the gut microbiome is contributing to Alzheimer's disease, in which case altering the gut microbiome with probiotics or fecal transfers might help change the course of the disease."

The idea of studying the connection between the gut microbiome and Alzheimer's disease came together at a youth soccer game, where Dantas and Beau M. Ances, MD, PhD, the Daniel J. Brennan Professor of Neurology, chatted while their children played. Ances treats and studies people with Alzheimer's disease; Dantas is an expert on the gut microbiome.

Scientists already knew that the gut microbiomes of people with symptomatic Alzheimer's differ from the microbiomes of healthy people of the same age. But, Ances told Dantas, nobody had yet looked at the gut microbiomes of people in the critical pre-symptomatic phase.

"By the time people have cognitive symptoms, there are significant changes that are often irreversible," said Ances, the other co-corresponding author. "But if you can diagnosis someone very early in the disease process, that would be the optimal time to effectively intervene with a therapy."

During the early stage of Alzheimer's disease, which can last two decades or more, affected people accumulate clumps of the proteins amyloid beta and tau in their brains, but do not exhibit signs of neurodegeneration or cognitive decline.

Dantas, Ances and first author Aura L. Ferreiro, PhD, then a graduate student in Dantas' lab and now a postdoctoral researcher, evaluated participants who volunteer for studies at the Charles F. and Joanne Knight Alzheimer Disease Research Center at Washington University. All participants were cognitively normal. As part of this study, participants provided stool, blood and cerebrospinal fluid samples; kept food diaries; and underwent PET and MRI brain scans.

To distinguish participants already in the early stage of Alzheimer's disease from those who were healthy, the researchers looked for signs of amyloid beta and tau accumulation through brain scans and cerebrospinal fluid. Of the 164 participants, about a third (49) had signs of early Alzheimer's.

An analysis revealed that healthy people and people with preclinical Alzheimer's disease have markedly different gut bacteria -- in terms of the species of bacteria present and the biological processes in which those bacteria are involved -- despite eating basically the same diet. These differences correlated with amyloid and tau levels, which rise before cognitive symptoms appear, but did not correlate with neurodegeneration, which becomes evident about the time cognitive skills start to decline. These differences potentially could be used to screen for early Alzheimer's disease, the researchers said.

"The nice thing about using the gut microbiome as a screening tool is its simplicity and ease," Ances said. "One day individuals may be able to provide a stool sample and find out if they are at increased risk for developing Alzheimer's disease. It would be much easier and less invasive and more accessible for a large proportion of the population, especially underrepresented groups, compared to brain scans or spinal taps."

The researchers have launched a five-year follow-up study designed to figure out whether the differences in the gut microbiome are a cause or a result of the brain changes seen in early Alzheimer's disease.

"If there is a causative link, most likely the link would be inflammatory," said Dantas, who is also a professor of pathology & immunology, of biomedical engineering, of molecular microbiology and of pediatrics. "Bacteria are these amazing chemical factories, and some of their metabolites affect inflammation in the gut or even get into the bloodstream, where they can influence the immune system all over the body. All of this is speculative at this point, but if it turns out that there is a causal link, we can start thinking about whether promoting 'good' bacteria or getting rid of 'bad' bacteria could slow down or even stop the development of symptomatic Alzheimer's disease."

https://www.sciencedaily.com/releases/2023/06/230614220554.htm

Conflict in marriage less harmful for kids when dad keeps it constructive

June 14, 2023

Science Daily/University of Illinois College of Agricultural, Consumer and Environmental Sciences

Conflict is unavoidable in all marriages. When it erupts in families with children, stressed or angry parents may take their pain out on the kids, projecting their anger or withdrawing emotionally or physically. In the worst cases, children's socioemotional development can suffer. But the way parents, especially fathers, deal with marital conflict can make a difference to kids, according to a new study from researchers at the University of Illinois Urbana-Champaign.

"In the past, marital conflict has always been considered a negative thing in reference to various aspects of child development. But what's more important than having conflict is how people deal with it. Our study looked at whether constructive conflict resolution could buffer some of the negative influence of marital conflict on parenting practices," said lead author Qiujie Gong, a doctoral student in the Department of Human Development and Family Studies (HDFS) in the College of Agricultural, Consumer and Environmental Sciences at Illinois.

Some studies have shown father-child relationships may be more impacted by conflict than mother-child relationships, and can lead to negative development for kids. That's why the authors chose to focus on fathers in their study.

"We wanted to pay more attention to fathers, because while mothers have always been considered the main caregiver, fathers can also significantly influence children's development," Gong said.

The authors, including HDFS professors Karen Kramer and Kelly Tu, accessed a longitudinal dataset from the U.S. Department of Education tracing children's experiences from 9 months to kindergarten. Recognizing the importance of the preschool years for learning socioemotional skills, they analyzed the subset of data for families with 4-year-olds and, controlling for mother's parenting styles, honed in on fathers' responses to survey questions about marital conflict and resolution strategies. Building links in a chain, they connected fathers' reports of conflict to their parenting practices, then to the socioemotional impacts of those practices on children.

"Beyond looking separately at mothers, fathers, and conflict, as previous studies have done, we put it all together in one model, not only to see the family as an interconnected system but also to not forget the father: How his perceptions of conflict and approaches to resolution affect child socioemotional development," said Kramer. "That's the uniqueness of this study."

Analyzing a diverse sample of 3,955 heterosexual families with resident fathers, the authors found when fathers reported more frequent marital conflict, it increased their parenting stress and decreased their warmth toward their child. According to the analysis, those factors then decreased the child's socioemotional skills reported by mothers in the surveys.

Gong emphasizes preschool-age children are at a crucial stage for developing socioemotional skills. These early experiences set the stage for later peer relationships, mental health, and more, so parents of small children should consider how their interactions may spill over to their kids, she says.

Next, Gong factored in how fathers resolved conflict.

"We found fathers who reported using more constructive conflict resolution -- like open communication and reaching compromise, as opposed to hitting, criticizing, or throwing things -- showed more involvement and warmth toward their kids, compared to their counterparts," she said.

Not surprisingly, children benefited from these warmer interactions with their dads.

"Fathers using constructive conflict resolution led to more parental involvement, which led to more positive child development," Kramer said. "Destructive conflict has the opposite effect on kids."

In the end, Gong says parents shouldn't shy away from conflict. Instead, what's more important is to find constructive resolution strategies that minimize stress and maintain a father's ability to interact warmly with his children.

"If we could have more clinical or educational programs that teach parents how to openly communicate with each other, how to listen to each other, and maintain good relationships with family members, it might be effective in promoting healthier family and child development," Gong said. "It's also important to not only consider the amount of parenting, but the quality of parenting. Even if fathers have a lot of involvement, if their warmth is super low, that might not be beneficial for the child."

Kramer adds that although the study focused exclusively on married couples, fathers in other family arrangements can still learn from the study.

"These lessons don't only apply to married couples. In fact, I would say they are even more important when you are not living together, or you're separated or divorced," she said. "You might have even more conflict in those cases, so the process of solving it might be even more important to the development of the child."

https://www.sciencedaily.com/releases/2023/06/230614220533.htm

What's an underrated way to study decisions? Think out loud

Researchers developed an online protocol for recording audio of people thinking aloud when trying to overcome trick questions

June 13, 2023

Science Daily/Stevens Institute of Technology

A philosopher-scientist and other researchers have developed an online protocol for recording audio as people narrate all of their thoughts while answering a series of trick questions. The work may not only help scientist reveal how people solve reasoning problems, but help optimize analysts' reports and briefings that inform high-level decisions.

Think fast: if you're running a race and overtake the person in second place, what position are you in? Many people instinctively respond that you're in first place. However, upon reflection, some people realize the correct answer is that you're now in second place: the former number-two runner slipped into third as you overtook them.

Trick questions of this kind are invaluable to cognitive scientists because they shed light on the cognitive quirks that shape our decision-making. "These aren't just trick questions," explained Nick Byrd, a philosopher-scientist and Intelligence Community Fellow who led the research at Stevens Institute of Technology. "They're opportunities to reveal whether we are thinking reflectively -- sometimes we are lured into accepting faulty responses that feel right."

In their work, Byrd's team worked with research startup Phonic, Inc., to develop an online protocol for recording audio as people narrate all of their thoughts while answering a series of trick questions. The work, reported in a special issue of the Journal of Intelligence, may not only help scientist reveal how people solve reasoning problems, but help optimize analysts' reports and briefings that inform high-level decisions.

"The mind is often a black box, and figuring out what's going on inside is challenging," Byrd explained. "Brain imaging is useful, but we can also learn a great deal simply by asking people to say whatever they're thinking."

However, think-out-loud experiments come at a cost: Recording people thinking out loud is much more complex and time-consuming than surveys. "It took three of us three months to complete an in-person think-aloud study -- and just one of us three hours to complete an online survey with the same number of subjects," Byrd said.

The new tool will significantly decrease the amount of time for completing think-out-loud experiments, lifting the lid on the black box for how humans overcome trick questions.

The paper shows that both online and in-person think-aloud testing can offer valuable insights into subjects' cognitive world. Many researchers focus on whether subjects fall for the trick or give correct answers, assuming that arriving at correct responses involved careful reflection and falling for the tricks did not. In the think-aloud recordings, however, Byrd's team found that in as many as 31% of cases, the opposite was true. "Sometimes people were tricked despite thinking reflectively, and sometimes people were correct without reflecting," Byrd said.

Presented with the race-position question, for instance, one subject gave the correct answer almost immediately -- then explained that it was easy for them, since they'd run track in high school. "It turns out that with enough relevant experience you can answer quickly without falling for the lure," Byrd said. "That might sound like a trivial insight, but higher education's publish-or-perish environment discourages scientists from using resource-intensive methods like think-aloud protocols to detect and quantify such measurement error."

Having shown that online surveys can streamline think-aloud audio collection, Byrd and colleagues now hope to use AI tools to streamline the analysis, making it possible to quickly record and interpret think-aloud data. That added efficiency would enable more researchers to conduct larger studies, study more diverse and representative groups of people, and obtain greater confidence in their results.

"One complaint about psychological science is its focus on student research participants in countries like the United States, who aren't necessarily representative of the whole of humanity," Byrd said. "Our online method will enable researchers to reach anyone with a smartphone and an internet connection, which includes most of the world's population."

The stakes can be high in decision-making: the U.S. Intelligence Community pays close attention to techniques that overcome faulty thinking. "If you're making important decisions, our think-aloud recordings show that people were much more likely to overcome mistakes if they questioned their initial impulse and considered some reasons," Byrd said. "So, helping scientists reveal how people solve reasoning problems may improve not only our decision science, but also our decision-making."

https://www.sciencedaily.com/releases/2023/06/230613190808.htm

Entrepreneurs' brains: Researchers reveal increased cognitive flexibility

A pioneering and multidisciplinary study involving serial entrepreneurs and managers found evidence of increased neuronal connectivity in the brains of entrepreneurs, which may contribute to distinct cognitive attributes

June 13, 2023

Science Daily/University of Liege

In a pioneering study involving serial entrepreneurs and managers, a multidisciplinary research team led by HEC -- School of Management at the University of Liège and Liège University Hospital (CHU Liège), combining entrepreneurship researchers and brain specialists, found evidence of increased neuronal connectivity in the brains of entrepreneurs, which may contribute to distinct cognitive attributes.

Using resting-state functional magnetic resonance imaging (rs-fMRI), the study showed that serial entrepreneurs have higher connectivity between the right insula (associated with cognitive flexibility) and the anterior prefrontal cortex (a key region for exploratory choices), compared to their fellow managers. These results, published in the journal Entrepreneurship Theory and Practice, suggest that serial entrepreneurs possess greater cognitive flexibility, enabling them to alternate effectively between exploration and exploitation, a balance that is crucial to their success.

Unlike the traditional fMRI approach based on tasks submitted to the subject, the rs-fMRI on which this study is based observes the brain at rest, in the absence of cognitive tasks or presentation of stimuli, which constitutes an innovative approach to improving understanding of the entrepreneurial mind. Forty people, entrepreneurs and managers, took part in the study.

"This study represents an important advance in our understanding of the entrepreneurial mind. It highlights the potential of neuroscience and how this approach complements the traditional tools used to study entrepreneurial cognition. By highlighting the difference in cognitive flexibility, it also offers a new perspective to inform the design of training or professional development programmes aimed at improving the cognitive flexibility and entrepreneurial spirit of individuals within various organisations," explains Frédéric Ooms, researcher and Assistant Professor in management and entrepreneurship (HEC -- ULiège School of Management), first author of the publication, based on the results of his PhD thesis on entrepreneurial cognitive flexibility presented in April 2023.

"In a world of rapid and unpredictable change, organisations need to cultivate an entrepreneurial mindset and foster cognitive flexibility within their teams, qualities recognised by the OECD as a 21st century challenge," points out Professor Bernard Surlemont, Professor of Entrepreneurship at ULiège (HEC Liège).

https://www.sciencedaily.com/releases/2023/06/230613110035.htm

Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk

The findings could help in identifying new interventions that reduce the brain's stress activity without the negative health effects of alcohol

June 12, 2023

Science Daily/Massachusetts General Hospital

A new study led by investigators from Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, offers an explanation for why light-to-moderate alcohol consumption may be associated with lower risk of heart disease. For the first time, researchers found that alcohol, in light to moderate quantities, was associated with long-term reductions in stress signaling in the brain. This impact on the brain's stress systems appeared to significantly account for the reductions in cardiovascular events seen in light to moderate drinkers participating in the study. Findings are published in the Journal of the American College of Cardiology.

"We are not advocating the use of alcohol to reduce the risk of heart attacks or strokes because of other concerning effects of alcohol on health," says senior author and cardiologist Ahmed Tawakol, MD, co-director of the Cardiovascular Imaging Research Center at Massachusetts General Hospital. "We wanted to understand how light to moderate drinking reduces cardiovascular disease, as demonstrated by multiple other studies. And if we could find the mechanism, the goal would be to find other approaches that could replicate or induce alcohol's protective cardiac effects without the adverse impacts of alcohol."

Previous epidemiological studies have suggested that light to moderate alcohol consumption (1 drink per day for women and 1 to 2 drinks per day for men) is associated with a lower risk of cardiovascular disease. But it was unknown whether alcohol was inducing cardiovascular benefits, or whether light/moderate drinkers' health behaviors, socioeconomic status, or other factors protected their hearts.

The study, led by K Mezue and M Osborne, included more than 50,000 individuals enrolled in the Mass General Brigham Biobank. The first part of the study evaluated the relationship between light/moderate alcohol consumption and major adverse cardiovascular events after adjusting for a range of genetic, clinical, lifestyle, and socioeconomic confounders. The researchers found that light/moderate alcohol consumption was associated with a substantial reduction in the risk of cardiovascular disease events, even after accounting for those other factors.

Next, they studied a subset of 754 individuals who had undergone previous PET/CT brain imaging (primarily for cancer surveillance) to determine the effect of light/moderate alcohol consumption on resting stress-related neural network activity.

The brain imaging showed reduced stress signaling in the amygdala, the brain region associated with stress responses, in individuals who were light to moderate drinkers compared to those who abstained from alcohol or who drank little. And when the investigators looked at these individuals' history of cardiovascular events, they found fewer heart attacks and strokes in light to moderate drinkers. "We found that the brain changes in light to moderate drinkers explained a significant portion of the protective cardiac effects," says Tawakol.

It's long been known that alcohol reduces the amygdala's reactivity to threatening stimuli while individuals are drinking. The current study is the first to indicate that light to moderate alcohol consumption has longer-term neurobiological effects in dampening activity in the amygdala, which may have a significant downstream impact on the cardiovascular system.

"When the amygdala is too alert and vigilant, the sympathetic nervous system is heightened, which drives up blood pressure and increases heart rate, and triggers the release of inflammatory cells," explains Tawakol. "If the stress is chronic, the result is hypertension, increased inflammation, and a substantial risk of obesity, diabetes, and cardiovascular disease."

Finally, the investigators examined whether light/moderate alcohol would be even more effective at reducing heart attacks and strokes in people who are prone to a chronically higher stress response, such as those with a history of significant anxiety. They found that, within the 50,000-patient sample, light to moderate drinking was associated with nearly double the cardiac-protective effect in individuals with a history of anxiety compared with others.

Yet while light/moderate drinkers lowered their risk for cardiovascular disease, the study also showed that any amount of alcohol increases the risk of cancer. And at higher amounts of alcohol consumption -- more than 14 drinks a week -- heart attack risk started to increase while overall brain activity started to decrease (which may be associated with adverse cognitive health).

The authors concluded that research should focus on finding new interventions that reduce the brain's stress activity without the deleterious effects of alcohol. The research team is currently studying the effect of exercise, stress-reduction interventions such as meditation, and pharmacological therapies on stress-associated neural networks and how they might induce cardiovascular benefits.

Co-authors include Kenechukwu Mezue and Michael T. Osborne.

This study was supported by the National Institutes of Health.

https://www.sciencedaily.com/releases/2023/06/230612200347.htm

New study links contraceptive pills and depression

June 12, 2023

Science Daily/Uppsala University

Women who used combined contraceptive pills were at greater risk of developing depression than women who did not, according to a new study. Contraceptive pills increased women's risk by 73 per cent during the first two years of use.

In a global perspective, depression is the leading cause of ill health and disability. More than 264 million people are affected and at least 25 per cent of all women and 15 per cent of all men experience a depression that requires treatment at some point during their life.

The possibility that contraceptive pills might have negative effects on mental health and even lead to depression has long been discussed. Although many women choose to stop using contraceptive pills because of the influence on their mood, until now the picture emerging from research has not been straightforward. This study is one of the largest and widest-ranging to date, following more than a quarter of a million women from UK Biobank from birth to menopause.

The researchers collected data about women's use of contraceptive pills, the time at which they were first diagnosed with depression and when they first experienced symptoms of depression without receiving a diagnosis. The method of contraception studied was combined contraceptive pills, which contain progestogen, a compound resembling the hormone progesterone, and oestrogen. Progestogen prevents ovulation and thickens the cervical mucus to prevent sperms from entering the uterus, while oestrogen thins the uterine lining to hinder the implantation of a fertilised egg.

"Although contraception has many advantages for women, both medical practitioners and patients should be informed about the side-effects identified in this and previous research," says Therese Johansson of the Department of Immunology, Genetics and Pathology at Uppsala University, one of the researchers leading the study.

According to the study, women who began to use contraceptive pills as teenagers had a 130 per cent higher incidence of symptoms of depression, while the corresponding increase among adult users was 92 per cent.

"The powerful influence of contraceptive pills on teenagers can be ascribed to the hormonal changes caused by puberty. As women in that age group have already experienced substantial hormonal changes, they can be more receptive not only to hormonal changes but also to other life experiences," Johansson says.

The researchers were also able to see that the increased incidence of depression declined when the women continued to use contraceptive pills after the first two years. However, teenage users of contraceptive pills still had an increased incidence of depression even after stopping using the pill, which was not observed in adult users of contraceptive pills.

"It is important to emphasise that most women tolerate external hormones well, without experiencing negative effects on their mood, so combined contraceptive pills are an excellent option for many women. Contraceptive pills enable women to avoid unplanned pregnancies and they can also prevent illnesses that affect women, including ovarian cancer and uterine cancer. However, certain women may have an increased risk of depression after starting to use contraceptive pills."

The findings of the study point to a need for healthcare professionals to be more aware of possible links between different systems in the body, such as depression and the use of contraceptive pills. The researchers conclude that it is important for care providers to inform women who are considering using contraceptive pills of the potential risk of depression as a side-effect of the medicine.

"Since we only investigated combined contraceptive pills in this study, we cannot draw conclusions about other contraceptive options, such as mini pills, contraceptive patches, hormonal spirals, vaginal rings or contraceptive rods. In a future study, we plan to examine different formulations and methods of administration. Our ambition in comparing different contraceptive methods is to give women even more information to help them take well-informed decisions about their contraceptive options," Johansson says.

https://www.sciencedaily.com/releases/2023/06/230612114717.htm

Loneliness, insomnia linked to work with AI systems

fter-work drinking also associated with AI work

June 12, 2023

Science Daily/American Psychological Association

Employees who frequently interact with artificial intelligence systems are more likely to experience loneliness that can lead to insomnia and increased after-work drinking, according to research published by the American Psychological Association.

Researchers conducted four experiments in the U.S., Taiwan, Indonesia and Malaysia. Findings were consistent across cultures. The research was published online in the Journal of Applied Psychology.

In a prior career, lead researcher Pok Man Tang, PhD, worked in an investment bank where he used AI systems, which led to his interest in researching the timely issue.

"The rapid advancement in AI systems is sparking a new industrial revolution that is reshaping the workplace with many benefits but also some uncharted dangers, including potentially damaging mental and physical impacts for employees," said Tang, an assistant professor of management at the University of Georgia. "Humans are social animals, and isolating work with AI systems may have damaging spillover effects into employees' personal lives."

At the same time, working with AI systems may have some benefits. The researchers found that employees who frequently used AI systems were more likely to offer help to fellow employees, but that response may have been triggered by their loneliness and need for social contact.

Furthermore, the studies found that participants with higher levels of attachment anxiety -- the tendency to feel insecure and worried about social connections -- responded more strongly to working on AI systems with both positive reactions, such as helping others, and negative ones, such as loneliness and insomnia.

In one experiment, 166 engineers at a Taiwanese biomedical company who worked with AI systems were surveyed over three weeks about their feelings of loneliness, attachment anxiety and sense of belonging. Coworkers rated individual participants on their helpful behaviors, and family members reported on participants' insomnia and after-work alcohol consumption. Employees who interacted more frequently with AI systems were more likely to experience loneliness, insomnia and increased after-work alcohol consumption, but also showed some helping behaviors toward fellow employees.

In another experiment with 126 real estate consultants in an Indonesian property management company, half were instructed not to use AI systems for three consecutive days while the other half were told to work with AI systems as much as possible. The findings for the latter group were similar to the previous experiment, except there was no association between the frequency of AI use and after-work alcohol consumption.

There were similar findings from an online experiment with 214 full-time working adults in the U.S. and another with 294 employees at a Malaysian tech company.

The research findings are correlational and don't prove that work with AI systems causes loneliness or the other responses, just that there is an association among them.

Tang said that moving forward, developers of AI technology should consider equipping AI systems with social features, such as a human voice, to emulate human-like interactions. Employers also could limit the frequency of work with AI systems and offer opportunities for employees to socialize.

Team decision-making and other tasks where social connections are important could be done by people, while AI systems could focus more on tedious and repetitive tasks, Tang added.

"Mindfulness programs and other positive interventions also might help relieve loneliness," Tang said. "AI will keep expanding so we need to act now to lessen the potentially damaging effects for people who work with these systems."

https://www.sciencedaily.com/releases/2023/06/230612114659.htm

New research identifies cells linking chronic psychological stress to inflammatory bowel disease

June 8, 2023

Science Daily/University of Pennsylvania School of Medicine

For the first time, cells involved with the communication between stress responses in the brain and inflammation in the gastrointestinal (GI) tract have been identified in animal models, according to findings from the Perelman School of Medicine at the University of Pennsylvania, published recently in Cell. Glial cells, which support neurons, communicate stress signals from the central nervous system (CNS) to the semi-autonomous nervous system within the gastrointestinal (GI) tract, called the enteric nervous system (ENS). These psychological stress signals can cause inflammation and exacerbate symptoms of inflammatory bowel disease (IBD).

An estimated 1.6 million Americans currently have IBD, which refers to two conditions -- Crohn's disease and ulcerative colitis -- characterized by inflammation of the GI tract, and can cause symptoms like persistent diarrhea, abdominal pain, and bloody stools. Prolonged inflammation can also lead to permanent damage to the GI tract. Current treatments consist of anti-inflammatory drugs, immune suppressants, dietary changes, and steroids.

"Clinicians have long observed that chronic stress can worsen IBD symptoms, but until now, no biological connection has been identified to explain how the digestive system knows when someone is stressed," said senior author Christoph Thaiss, PhD, an assistant professor of Microbiology.

In the study, researchers found that, like humans, mice with IBD developed severe symptoms when stressed. They traced the initial stress response signals to the adrenal cortex, which releases glucocorticoids -- steroid hormones that activate the physiological responses to stress throughout the body. The researchers found that neurons and glia in the ENS responded to chronically elevated glucocorticoid levels, suggesting that they are the link between stress perception by the brain and intestinal inflammation.

While glucocorticoids typically have an anti-inflammatory effect in the body, the researchers found that when glia in the ENS were exposed to the steroid hormones for a prolonged period, such as during chronic stress, they attract white blood cells to the GI tract that increase inflammation. The researchers also found that when exposed to chronic stress, the neurons in the ENS in the GI tract stop functioning as they normally do, which can lead to impaired bowel movements and exacerbated IBD symptoms.

Thaiss and collaborators verified the connection between psychological stress and IBD symptoms in humans using the UK Biobank and a patient cohort from the IBD Immunology Initiative at Penn Medicine. They found that the in patients with an IBD diagnosis, the level of reported stress correlated with an increased severity of IBD symptoms.

"This finding highlights the importance of psychological evaluations in patients being treated for IBD, as well as to inform treatment protocols," said Maayan Levy, PhD, an assistant professor of Microbiology and co-senior author of the study. "One of the most common treatments for IBD flare-ups is steroids, and our research indicates that in patients with IBD who experience chronic stress, the efficiency of this treatment could be impaired."

Researchers underscore the opportunity for more research into the biology of enteric glial cells, and the role they play in many regulatory systems within the body, including the communication between the nervous system and the immune system.

https://www.sciencedaily.com/releases/2023/06/230608195659.htm