Brain injury researchers find retrieval practice improves memory in youth with TBI

December 3, 2014

Science Daily/Kessler Foundation

Brain injury researchers have identified retrieval practice as a useful strategy for improving memory among children and adolescents with traumatic brain injury, researchers have found. Difficulties with memory and learning are common after TBI in childhood. To improve academic achievement and long-term outcomes such as employment, effective neurorehabilitative strategies need to be identified, they note.

Difficulties with memory and learning are common after TBI in childhood. To improve academic achievement and long-term outcomes such as employment, effective neurorehabilitative strategies need to be identified.

The researchers studied 15 patients with TBI and impaired memory, aged 8 to 16 years. They compared results of three memory strategies: massed restudy (cramming), spaced restudy (restudying of material at timed intervals), and retrieval practice (quizzing during the learning stage). Participants were tested on verbal-paired associates and face-name pairs.

"We found that retrieval practice resulted in better recall," said Dr. Coyne. "Overall, retrieval practice was the best learning strategy for each of the participants, indicating that this method can improve learning and memory in this age group with TBI. There's a need for randomized controlled trials to confirm this finding, and look at the impact of retrieval practice on academic achievement."

http://www.sciencedaily.com/releases/2014/12/141203161136.htm

Copper on the brain at rest

November 26, 2014

Science Daily/DOE/Lawrence Berkeley National Laboratory

Proper copper levels are essential to the health of the brain at rest, new research shows. The brain consumes 20-percent of the oxygen taken in through respiration. This high demand for oxygen and oxidative metabolism has resulted in the brain harboring the body's highest levels of copper, as well as iron and zinc. Over the past few years, researchers have developed a series of fluorescent probes for molecular imaging of copper in the brain.

In recent years it has been established that copper plays an essential role in the health of the human brain. Improper copper oxidation has been linked to several neurological disorders including Alzheimer's, Parkinson's, Menkes' and Wilson's. Copper has also been identified as a critical ingredient in the enzymes that activate the brain's neurotransmitters in response to stimuli. Now a new study by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) has shown that proper copper levels are also essential to the health of the brain at rest.

"The results of our study show that there are significant and similar preventive effects of PE and CT," the authors conclude. "Our finding suggests that delaying the intervention does not increase the risk of chronic PTSD…Thus, a delayed intervention is an acceptable option when early clinical interventions cannot be provided (e.g., during wars, disasters, or continuous hostilities)."

The results of this study suggest that the mismanagement of copper in the brain that has been linked to Wilson's, Alzheimer's and other neurological disorders can also contribute to misregulation of signaling in cell−to-cell communications.

"Our results hold therapeutic implications in that whether a patient needs copper supplements or copper chelators depends on how much copper is present and where in the brain it is located," Chang says. "These findings also highlight the continuing need to develop molecular imaging probes as pilot screening tools to help uncover unique and unexplored metal biology in living systems."

http://www.sciencedaily.com/releases/2014/11/141126124411.htm

Sleep disorders found to be highly prevalent in firefighters

November 13, 2014

Science Daily/Brigham and Women's Hospital

In a national sample of almost 7,000 firefighters, researchers examined the prevalence of common sleep disorders and their association with adverse health and safety outcomes and found that sleep disorders are highly prevalent, and associated with substantially increased risk of motor vehicle crashes and cardio-metabolic diseases among firefighters.

"Our findings demonstrate the impact of common sleep disorders on firefighter health and safety, and their connection to the two leading causes of death among firefighters," said Barger. "Unfortunately, more than 80 percent of firefighters who screened positive for a common sleep disorder were undiagnosed and untreated."

Researchers found that a total of 37.2 percent of firefighters screened positive for sleep disorders including obstructive sleep apnea, insomnia, shift work disorder and restless leg syndrome. Firefighters with a sleep disorder were more likely to report a motor vehicle crash and were more likely to report falling asleep while driving than those who did not screen positive. Additionally, firefighters with sleep disorders were more likely to report having cardiovascular disease, diabetes, depression and anxiety, and to report poorer health status, compared with those who did not screen positive.

http://www.sciencedaily.com/releases/2014/11/141113085220.htm

Predicting U.S. Army suicides after hospital discharge

November 12, 2014

Science Daily/Harvard Medical School

Some Army suicides can be predicted with enough accuracy to justify implementing preventive interventions in patients at high risk, experts say. The study looked at 53,769 regular Army soldiers during the 12-month period following their discharge from a psychiatric facility during 2004 to 2009. Hundreds of potential predictors of post-hospital suicide were abstracted from the extensive Army and Department of Defense administrative files that contain data on all soldiers.

"The high concentration of suicide risk in the 5 percent of highest-risk hospitalizations is striking," said lead author Ronald Kessler, McNeil Family Professor of Health Care Policy at Harvard Medical School. "The fact that nearly half of all highest-risk hospitalizations were followed by at least one adverse outcome -- either suicide, unintentional injury death, suicide attempt or rehospitalization -- argues strongly for developing expanded post-hospital preventive intervention services for these highest-risk soldiers."

http://www.sciencedaily.com/releases/2014/11/141112203216.htm

Soldiers at increased risk for suicide within a year of psychiatric in-patient treatment

November 12, 2014

Uniformed Services University of the Health Sciences (USU)

Soldiers hospitalized with a psychiatric disorder have a significantly elevated risk for suicide in the year following hospital discharge, according to research. Although this has long been known in the civilian sector, it has never before been studied in the military population.

The study used data from the Army Study to Assess Risk and Resilience in Service members (Army STARRS), the largest study of mental health risk and resilience ever conducted among U.S. Army personnel. Robert J. Ursano, MD, chair of the Department of Psychiatry at the Uniformed Services University, Murray B. Stein, MD, MPH, professor of Psychiatry and Family and Preventive Medicine at the University of California, San Diego, both co-principal investigators for Army STARRS, and a team of Army STARRS researchers looked at data from the 12 months following a hospital discharge for more than 40,000 regular Army soldiers (excluding National Guard and Reserve) who served on active duty from 2004 through 2009.

The Army's suicide rate began increasing in 2004, exceeded the rate among U.S. civilians (adjusted to match the sex and age distribution of the Army), in 2009, and has remained high through 2014. This study of administrative data shows that 40,820 soldiers (0.8% of all regular Army soldiers who served from 2004-2009) were hospitalized with a psychiatric disorder. Suicides occurring in this group during the year after a hospital discharge accounted for 12% of all Army suicides during this period.

Researchers also found that it was possible to identify smaller, higher-risk groups within this at-risk population. Analyzing soldiers' characteristics and experiences prior to and during hospitalization, researchers identified the 5% of soldiers with the highest predicted risk of suicide after leaving the hospital. This top 5% accounted for 52.9% of the post-hospital suicides. Soldiers in this top 5% also accounted for a greater proportion of accident deaths, suicide attempts, and re-hospitalizations, compared to other previously hospitalized soldiers.

http://www.sciencedaily.com/releases/2014/11/141112161040.htm

Mental health providers not well prepared to care for military veterans

November 12, 2014

Science Daily/RAND Corporation

Policymakers have expanded military veterans' access to community-based health providers as a way to meet demands, given capacity constraints in the VA health system. But a new study finds that most community-based mental health providers are not well prepared to take care of the special needs of military veterans and their families.

"Our findings suggest that community-based mental health providers are not as well prepared as they need to be to address the needs of veterans and their families," said Terri Tanielian, the study's lead author and a senior social research analyst at RAND, a nonprofit research organization. "There is a need for increased training among community-based providers in high quality treatment techniques for PTSD and other disorders that are more common among veterans."

"Veterans and their family members face unique challenges, and addressing their needs requires understanding military culture as well as their mental health challenges," said retired Navy Vice Adm. Norb Ryan, president of the Military Officers Association of America. "It's crucial that our civilian mental health providers acquire the training and perspective they need to guide their practice in the care of our military and veteran population."

The study recommends that organizations that maintain registries or provider networks include information about mental health practitioners' ability to properly treat the special needs of military and veteran populations.

http://www.sciencedaily.com/releases/2014/11/141112102638.htm

Federal legislation ignores PTSD toll on civilians

November 11, 2014

Science Daily/Drexel University

Federal laws explicitly addressing post-traumatic stress disorder (PTSD) have overwhelmingly focused on the needs of military personnel and veterans, according to a new analysis. The study is the first to examine how public policy has been used to address psychological trauma and PTSD in the US, providing a glimpse of how lawmakers think about these issues.

"Although trauma and PTSD are serious issues affecting military populations, the raw number of people affected by PTSD includes substantially more civilians simply because the civilian population is so much larger," said Purtle.

"It's almost as if lawmakers didn't want to suggest that PTSD was also a disorder among civilians," Purtle said. "This gives a sense of how elected officials at the federal level might think about the dimensions of this problem, and shows that it doesn't match up with what's known about who gets PTSD."

The emphasis on military personnel in legislation addressing PTSD may reflect the history of the disorder, which first became known through cases in military members and veterans following combat experiences. The federal government's role in providing medical care for veterans could also contribute to the legislation's heightened emphasis on military PTSD in contrast to civilian PTSD.

http://www.sciencedaily.com/releases/2014/11/141111124053.htm

Pregnant women with PTSD more likely to give birth prematurely

- November 6, 2014

Science Daily/Stanford University Medical Center

Pregnant women with post-traumatic stress disorder are at increased risk of giving birth prematurely, a new study has found. The study, which examined more than 16,000 births to female veterans, is the largest ever to evaluate connections between PTSD and preterm birth.

Having PTSD in the year before delivery increased a woman's risk of spontaneous premature delivery by 35 percent, the research showed. The results will be published online Nov. 6 in Obstetrics & Gynecology.

"This study gives us a convincing epidemiological basis to say that, yes, PTSD is a risk factor for preterm delivery," said the study's senior author, Ciaran Phibbs, PhD, associate professor of pediatrics and an investigator at the March of Dimes Prematurity Research Center at Stanford University. "Mothers with PTSD should be treated as having high-risk pregnancies."

Spontaneous preterm births, in which the mother goes into labor and delivers more than three weeks early, account for about six deliveries per 100 in the general population. This means that the risk imposed by PTSD translates into a total of about two additional premature babies for every 100 births. In total, about 12 babies per 100 arrive prematurely; some are born early because of medical problems for the mother or baby, rather than because of spontaneous labor.

The effect of stress

 In other words, although pregnant women with PTSD may have other health problems or behave in risky ways, it's the PTSD that counts for triggering labor early.

"The mechanism is biologic," Phibbs said. "Stress is setting off biologic pathways that are inducing preterm labor. It's not the other psychiatric conditions or risky behaviors that are driving it."

However, if a woman had been diagnosed with PTSD in the past but had not experienced the disorder in the year before giving birth, her risk of delivering early was no higher than it was for women without PTSD. "This makes us hopeful that if you treat a mom who has active PTSD early in her pregnancy, her stress level could be reduced, and the risk of giving birth prematurely might go down," said Phibbs, adding that the idea needs to be tested.

Although PTSD is more common in military veterans than the general population, a fairly substantial number of civilian women also experience PTSD, Phibbs noted. "It's not unique to the VA or to combat," he said, noting that half of the women in the study who had PTSD had never been deployed to a combat zone. "This is relevant to all of obstetrics."

The VA has already incorporated the study's findings into care for pregnant women by instructing each VA medical center to treat pregnancies among women with recent PTSD as high-risk. And Phibbs' team is now investigating whether PTSD may also contribute to the risk of the mother or baby being diagnosed with a condition that causes doctors to recommend early delivery for health reasons.

http://www.sciencedaily.com/releases/2014/11/141106173639.htm

Millennials prefer healthy habits, less likely to choose opioids to manage pain

Survey finds millennials regret opioid use, lack knowledge on proper disposal

August 30, 2017

Science Daily/American Society of Anesthesiologists

Often spending their days hunched over phones, tablets or computers and their free time at spin class or playing sports, millennials are the next generation poised to experience chronic pain. Even at their young age, millennials say acute and chronic pain are already interfering with their quality of life.

Their preferred method to manage pain? Lifestyle changes such as exercising, eating right, quitting smoking and losing weight, according to a nationwide survey commissioned by the American Society of Anesthesiologists (ASA) in conjunction with September's Pain Awareness Month.

The survey also found millennials were half as likely as baby boomers to have turned to opioids to manage pain, and 1 in 5 millennials regret that they used the highly addictive painkillers.

But while the results reflect a positive trend, they also reveal a knowledge gap. The survey found many millennials were:

• ·      More likely to obtain opioids inappropriately. One in 10 millennials obtained opioids through another household member's prescription, compared to 3 percent of Gen Xers, 1 percent of baby boomers and none of the silent generation.
• ·      More likely to think it's OK to take an opioid without a prescription. Nearly 30 percent of millennials thought it was OK to take an opioid without a prescription, compared to 20 percent of Gen Xers, 12 percent of baby boomers and 3 percent of the silent generation.
• ·      AND less likely to dispose of leftover opioids safely. In fact, 1 in 5 millennials said they "did not know" the best way to safely dispose of opioids, and only 37 percent were aware that a collection center at a local police station, hospital pharmacy or drug store was the best method of disposal.

"It's encouraging that millennials see the value of opting for safer and often more effective methods of managing pain," said ASA President Jeffrey Plagenhoef, M.D. "But clearly they are in need of further education when it comes to opioids and chronic pain because using the drugs initially to treat pain can turn into a lifelong struggle with addiction."

Learning how to manage pain safely and effectively is vital: 75 percent of millennials say they have had acute pain (which comes on suddenly and lasts less than three months) and nearly 60 percent have experienced chronic pain (which lasts longer than three months). The source of that pain is reflective of millennials' lifestyle, including technology use (leading to eye strain, neck aches, hand or finger pain, wrist or arm pain), migraines and sports injuries.

According to the survey, millennials (ages 18-36) and members of Generation X (ages 37-52) are most likely to report pain interfered with their work responsibilities, parenting abilities and participation in family activities.

It's important to address pain before it interferes with quality of life by seeing the right specialist for pain management. Whatever the age, people in severe pain who don't find relief through lifestyle changes should see a physician who specializes in pain management, such as a physician anesthesiologist. These specialists have received four years of medical school and additional training in a medical specialty, followed by an additional year of training to become an expert in treating pain. They have the expertise to best help you manage your pain.

But engaging in lifestyle changes before chronic pain can gain a further foothold is preferable. When possible, prevention is best. "Chronic pain does not have to be an automatic response to aging," said Dr. Plagenhoef. "Healthy lifestyle changes such as exercising, proper nutrition and maintaining a healthy weight can keep millennials from dealing with some of the chronic pain their parents and grandparents are experiencing."

To help all generations effectively manage their pain, ASA offers the following tips:

• ·      Take a break from devices and gaming: Aches from smartphone, tablet, gaming and other digital device overuse is common. To avoid it, use devices at eye level instead of looking down for long periods of time, which puts strain on your neck and back. Use the talk to text feature to limit finger and wrist strain. Sit up straight while gaming and get off the couch and stretch occasionally. To avoid digital eye strain, look away from the screen every 20 seconds and position yourself so there is an appropriate distance between your eyes and the screen.
• ·      Don't be a weekend warrior. Whether you plan to hit the basketball court after many years away or do CrossFit weekly, ease into it. Warm up your muscles and stretch to avoid pain and injury. If you think you've been injured after exercise or playing sports see a pain management specialist right away to evaluate the pain.
• ·      Remember to move. Whether you're in the library studying or at a desk job, get up and move at least once an hour, if not more. Sitting and being sedentary can lead to aches and pains, especially lower back pain. Stretch your legs and back by standing and walking on a regular basis rather than sitting for long periods of time.
• ·      Get healthy. Take charge of your health now and engage in healthy lifestyle changes before chronic pain sets in. Participate in low-impact aerobic and strength training exercises regularly. Maintain a healthy weight and eat a balanced diet. Don't smoke, or if you do, talk to a physician about programs available to help you quit.
• ·      Take and dispose of opioids the right way. If a physician prescribes opioids, ask many questions about taking them appropriately. Don't continue taking opioids when your pain subsides. If you have leftover opioids, dispose of them at a collection center at a local police station, hospital pharmacy, or drugstore. This will ensure others who have not been prescribed the opioids do not have access to them.

The 10-question ORC International CARAVAN® Omnibus Survey was conducted online August 7-9, 2017 among 1,011 U.S. adults 18 years or older: 34 percent were millennials, 25 percent were Gen Xers, 35 percent were baby boomers (ages 53-71) and 6 percent were from the silent generation (ages 72-92). The demographically representative sample included 504 men and 507 women.

https://www.sciencedaily.com/releases/2017/08/170830124926.htm

Pain, emotions and the placebo effect

August 29, 2017

Science Daily/University of Luxembourg

In a pioneering study, researchers used fMRI technology to show that a person’s ability to reinterpret negative events and to control feelings influences how strongly a placebo will work to reduce pain

"Brain scans showed researchers that specific regions in the brain react when a person receives a placebo and as a result experiences less pain," explains Dr Marian van der Meulen, neuropsychologist at the University of Luxembourg. "The regions in the brain that process pain become less active, which demonstrates that the placebo effect is real. But the psychological mechanism is still very little understood, and it is unclear why some people show a much stronger placebo response than others. We suspected that the way we can regulate our emotions plays a role and set out to investigate this."

Why is it important to better understand the placebo effect?

"It's important to understand that the placebo effect is not only an imagined improvement when we believe we receive a medication.

The placebo effect had traditionally a negative reputation. During the last decade however, researchers have investigated the placebo effect itself. They have shown that placebos can trigger real biological changes in the body, including the brain, and that the placebo effect plays a role every time we receive a medical treatment. The placebo effect not only happens when administering a bogus treatment, but is a part of every medical procedure. It is triggered by the presence of a white coat and other signs of medical authority, verbal suggestions of improvement and previous experiences with a treatment. Clinicians or psychiatrists may be able to improve the outcome of a medical intervention by optimising the contribution of the placebo effect."

How was the study carried out, and key findings

"The study was conducted in collaboration with the ZithaKlinik and uses fMRI (functional magnetic resonance imaging) of the brain to show a relationship between the regions in the brain that respond to a placebo and the ability to regulate emotions.

First, we assessed participants' ability for 'cognitive reappraisal', which means how well they can reinterpret negative emotions. Participants looked at images that create negative emotions. Their task was to come up with ideas or interpretations that made them feel more positive about an image and we measured how well they managed to do this. At the ZithaKlinik, participants were then put in the MRI scanner and they received painful heat stimuli on their arms. They were then told that they received a powerful pain-relieving cream, which in reality was just a simple skin moisturiser.

All participants reported less pain: the placebo effect was working. Interestingly, those with a higher capacity to control their negative feelings showed the largest responses to the placebo cream in the brain. Their activity in those brain regions that process pain was most reduced. This suggests that your ability to regulate emotions affects how strong your response to a placebo will be."

Which role does brain imaging play?

"When a brain area is more active, it consumes more oxygen and more blood will flow to this area. fMRI measures this change in blood flow and detects which areas of the brain are involved in a certain mental process. In our research we were able to detect decreases in activation in pain-processing regions but also increases in an area involved in emotion regulation.

This is the first study using functional brain imaging that was conducted in Luxembourg. Our next research project will use fMRI to assess, amongst others, the placebo effect in elderly people. We know that older people perceive and report pain differently than young people, yet why this is the case remains poorly understood. With improved understanding, clinicians and caretakers may be able to better diagnose and treat pain conditions in elderly people."

https://www.sciencedaily.com/releases/2017/08/170829131224.htm

Chronic lack of sleep increases risk-seeking

August 28, 2017

Science Daily/University of Zurich

Sleepiness, reduced concentration and performance -- more and more people are suffering from the consequences of a chronic lack of sleep. Researchers have now demonstrated a further consequence: the people affected are subject to more intensive risk-seeking behavior without even noticing.

Young adults have a natural sleep requirement of about 9 hours a day on average, older adults 7.5 hours. Many people in western societies, however, get considerably less sleep. According to studies, about one-third of the persons surveyed in several industrial countries reported too little sleep. If a young adult sleeps less than 8 hours a night, increased attention deficits occur, which can lead to considerable negative consequences. In sleep clinics there is an increasing number of healthy people who are suffering from the negative consequences of insufficient sleep.

Not enough sleep leads to riskier decision-making

Researchers at the University of Zurich and the University Hospital Zurich have now identified a further critical consequence of a chronic lack of sleep: increased risk-seeking. The sleep and neuroeconomics scientists studied the risk behavior of 14 healthy male students aged from 18 to 28 years. If the students slept only 5 hours a night for a week, they displayed clearly riskier behavior in comparison with a normal sleep duration of about 8 hours. Twice a day, they had to choose between obtaining a specified amount of money paid out with a given probability or playing it safe with a lower amount of money paid out for sure. The riskier the decision, the higher the possible prize -- but also the risk of getting nothing.

Riskier behavior remains unnoticed

While a single sleepless night had no effect on risk-seeking, 11 of 14 of the subjects behaved significantly and increasingly riskier as the week of a reduced sleep duration went on. An additional finding is particularly alarming: The students assess their risk-taking behavior to be the same as under regular sleep conditions. "We therefore do not notice ourselves that we are acting riskier when suffering from a lack of sleep," emphasizes Christian Baumann, professor of neurology and the head of the Clinical Research Priority Programs (CRPP) "Sleep and Health" at UZH. According to the authors of the study, we should therefore all strive for a sufficient sleep duration -- especially political and economic leaders who make wide-reaching decisions daily. "The good news is," Baumann says, "that, in the high-powered world of managers, getting enough sleep is increasingly being seen as desirable."

Lack of recovery in important regions of the brain

For the first time, the researchers have proven that a low depth of sleep in the right prefrontal cortex is directly connected with higher risk-seeking behavior. This part of the cerebral cortex has already been associated with risk-taking behavior in earlier studies. "We assume that behavioral changes occur for anatomical-functional reasons to some extent as a result of the right prefrontal cortex not being able to recover properly due to a chronic lack of sleep," Baumann concludes.

https://www.sciencedaily.com/releases/2017/08/170828102725.htm

Yoga and meditation improve mind-body health and stress resilience

New research finds that practicing yoga and meditation has positive effects on mind-body health and stress resilience

August 22, 2017

Science Daily/Frontiers

A new research article investigates the effects of yoga and meditation on people by looking at physiological and immunological markers of stress and inflammation. By studying the participants of an intensive three-month yoga and meditation retreat, the researchers found that the practices positively impacted physiological and immunological markers of stress and inflammation, and in addition improved subjective wellbeing.

Many people report positive health effects from practicing yoga and meditation, and experience both mental and physical benefits from these practices. However, we still have much to learn about how exactly these practices affect mind-body health. A new research article published in Frontiers in Human Neuroscience investigates the effects of yoga and meditation on brain derived neurotrophic factor (BDNF), the activity on the hypothalamic pituitary adrenal (HPA) effects and inflammatory markers. By studying the participants of an intensive 3-month yoga and meditation retreat, the researchers found that the practices positively impacted BDNF signaling, the cortisol awakening response (CAR) and immunological markers, and in addition improved subjective wellbeing.

In this study, the retreat participants were assessed before and after participating in a 3-month yoga and meditation retreat that involved daily meditation and Isha yoga, accompanied by a vegetarian diet. The yogic practices consisted of physical postures, controlled breathing practices, and seated meditations during which the participants focused on mantra repetition, breath, emptying the mind and bodily sensation. The researchers measured psychometric measures, brain derived neurotrophic factor (BDNF), circadian salivary cortisol levels, as well as pro- and anti-inflammatory cytokines. They also collected data on psychometric variables including mindfulness, absorption, depression and anxiety, and investigated the relationship between psychological improvements and biological changes.

The data showed that participation in the retreat was associated with decreases in both self-reported anxiety and depression as well as increases in mindfulness. The research team observed increases in the plasma levels of BDNF, a neuromodulator that plays an important role in learning, memory and the regulation of complex processes such as inflammation, immunity, mood regulation, stress response and metabolism. They also observed increases in the magnitude of the cortisol awakening response (CAR) which is part of the hypothalamic pituitary adrenal axis (HPA), suggesting improved stress resilience. Moreover, there was a decrease in inflammatory processes caused by an increase of the anti-inflammatory cytokine Interleukin-10 and a reduction of the pro-inflammatory cytokine Interleukin-12 after the retreat. "It is likely that at least some of the significant improvements in both HPA axis functioning as exemplified by the CAR as well as neuroimmunologic functioning as exemplified by increases in BDNF levels and alterations in cytokines were due to the intensive meditation practice involved in this retreat," says corresponding author Dr Baruch Rael Cahn (University of Southern California, USA).

The research team hypothesize that the pattern of biological findings observed in their study is linked to enhanced resilience and wellbeing. "The observed increased BDNF signaling possibly related to enhanced neurogenesis and/or neuroplasticity, increased CAR likely related to enhanced alertness and readiness for mind-body engagement, and increased anti- and pro-inflammatory cytokines possibly indicating enhanced immunological readiness," explains Dr Cahn. "An intriguing possible link between the effects on BDNF and the CAR is hippocampal functional integrity, since increased BDNF levels due to physical exercise has previously been shown to relate with hippocampal neurogenesis and likely relate to its positive effects on well-being and depression."

In the light of previous studies of the positive effects of meditation on mental fitness, autonomic homeostasis and inflammatory status, the researchers think that their findings are related to the meditative practices that the retreat participants engaged in. However, they suggest that some of the observed changes may also be related to the physical aspects of the retreat -- yoga practice and diet -- and that the observed change patterns are a reflection of wellbeing and mind-body integration. The next step will be to conduct further research in order to clarify the extent to which the positive changes on mind-body wellness and stress resilience are related to the yoga and meditation practices respectively, and to account for other possible contextual factors such as social dynamics, diet and the impact of the teacher. "To our knowledge, our study is the first to examine a broad range of pro- and anti-inflammatory markers in a healthy population before and after a yoga-meditation intervention. Our findings justify further studies of yoga and meditation retreats assessing for the replicability, specificity and long-term implications of these findings," concludes Dr Cahn.

https://www.sciencedaily.com/releases/2017/08/170822104855.htm

Higher coffee consumption associated with lower risk of early death

August 27, 2017

Science Daily/European Society of Cardiology

Higher coffee consumption is associated with a lower risk of early death, according to new research. The observational study in nearly 20 000 participants suggests that coffee can be part of a healthy diet in healthy people.

"Coffee is one of the most widely consumed beverages around the world," said Dr Adela Navarro, a cardiologist at Hospital de Navarra, Pamplona, Spain. "Previous studies have suggested that drinking coffee might be inversely associated with all-cause mortality but this has not been investigated in a Mediterranean country."

The purpose of this study was to examine the association between coffee consumption and the risk of mortality in a middle-aged Mediterranean cohort. The study was conducted within the framework of the Seguimiento Universidad de Navarra (SUN) Project, a long-term prospective cohort study in more than 22 500 Spanish university graduates which started in 1999.

This analysis included 19,896 participants of the SUN Project, whose average age at enrollment was 37.7 years old. On entering the study, participants completed a previously validated semi-quantitative food frequency questionnaire to collect information on coffee consumption, lifestyle and sociodemographic characteristics, anthropometric measurements, and previous health conditions.

Patients were followed-up for an average of ten years. Information on mortality was obtained from study participants and their families, postal authorities, and the National Death Index. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for incident mortality according to baseline total coffee consumption adjusted for potential confounders.

During the ten year period, 337 participants died. The researchers found that participants who consumed at least four cups of coffee per day had a 64% lower risk of all-cause mortality than those who never or almost never consumed coffee (adjusted HR, 0.36; 95% CI, 0.19-0.70). There was a 22% lower risk of all-cause mortality for each two additional cups of coffee per day (adjusted HR, 0.78; 95% CI, 0.66-0.92).

The researchers examined whether sex, age or adherence to the Mediterranean diet had any influence on the association between baseline coffee consumption and mortality. They observed a significant interaction between coffee consumption and age (p for interaction=0.0016). In those who were at least 45 years old, drinking two additional cups of coffee per day was associated with a 30% lower risk of mortality during follow-up (adjusted HR, 0.70; 95% CI, 0.58-0.85). The association was not significant among younger participants.

Dr Navarro said: "In the SUN project we found an inverse association between drinking coffee and the risk of all-cause mortality, particularly in people aged 45 years and above. This may be due to a stronger protective association among older participants."

She concluded: "Our findings suggest that drinking four cups of coffee each day can be part of a healthy diet in healthy people."

https://www.sciencedaily.com/releases/2017/08/170827101750.htm

Blue light emitted by screens damages our sleep

August 22, 2017

Science Daily/University of Haifa

The short-wavelength blue light, emitted by the screens we watch, damages the duration, and even more so, the quality of our sleep. The study also found that watching screens that emit red light does not cause damage, and sleep after exposure to it was similar to normal sleep.

Previous studies have already shown that watching screens before going to sleep damages our sleep. It has also been found that exposure to blue light with wave lengths of 450-500 nanometers suppresses the production of melatonin, a hormone secreted at night that is connected with normal body cycles and sleep. The new study, published in the journal Chronobiology International, was undertaken by researchers Prof. Abraham Haim, head of the Israeli center for interdisciplinary research in chronobiology at the University of Haifa; doctorate student Amit Shai Green of the Center for Interdisciplinary Chronobiological Research at the University of Haifa and the Sleep and Fatigue Center at Assuta Medical Center; Dr. Merav Cohen-Zion of the School of Behavioral Sciences at the Academic College of Tel Aviv-Yafo; and Prof. Yaron Dagan of the Research Institute for Applied Chronobiology at Tel Hai Academic College. The researchers sought to examine whether there is any difference in sleep patterns following exposure to blue screen light as compared to red light prior to sleep, and furthermore, to find which is more disruptive: wavelength or intensity?

The study participants were 19 healthy subjects aged 20-29 who were not aware of the purpose of the study. In the first part of the trial, the participants wore an actigraph for one week (an actigraph is a device that provides an objective measurement of the time when an individual falls asleep and wakes up). They also completed a sleep diary and a questionnaire about their sleeping habits and quality of sleep. In the second part of the trial, which took place at Assuta's Sleep Laboratory, the participants were exposed to computer screens from 9 p.m. to 11 p.m. -- the hours when the pineal gland begins to produce and excrete melatonin. The participants were exposed to four types of light: high-intensity blue light, low-intensity blue light, high-intensity red light, and low-intensity red light. Following exposure to light, they were connected to instruments that measure brain waves and can determine the stages of sleep a person undergoes during the course of the night, including awakenings not noticed by the participants themselves. In the morning, the participants completed various questionnaires relating to their feelings.

On average, exposure to blue light reduced the duration of sleep by approximately 16 minutes. In addition, exposure to blue light significantly reduced the production of melatonin, whereas exposure to red light showed a very similar level of melatonin production to the normal situation. The researchers explain that the impaired production of melatonin reflects substantial disruption of the natural mechanisms and the body's biological clock. Thus, for example, it was found that exposure to blue light prevents the body from activating the natural mechanism that reduces body temperature. "Naturally, when the body moves into sleep it begins to reduce its temperature, reaching the lowest point at around 4:00 a.m. When the body returns to its normal temperature, we wake up," Prof. Haim explains. "After exposure to red light, the body continued to behave naturally, but exposure to blue light led the body to maintain its normal temperature throughout the night -- further evidence of damage to our natural biological clock."

The most significant finding in terms of the disruption of sleep was that exposure to blue light drastically disrupts the continuity of sleep. Whereas after exposure to red light (at both intensities) people woke up an average of 4.5 times (unnoticed awakenings), following exposure to weak blue light 6.7 awakenings were recorded, rising to as many as 7.6 awakenings following exposure to strong blue light. Accordingly, it is hardly surprising that the participants reported in the questionnaires that the felt more tired and in a worse mood after exposure to blue light.

"Exposure to screens during the day in general, and at night in particular, is an integral part of our technologically advanced world and will only become more intense in the future. However, our study shows that it is not the screens themselves that damage our biological clock, and therefore our sleep, but the short-wave blue light that they emit. Fortunately various applications are available that filter the problematic blue light on the spectrum and replace it with weak red light, thereby reducing the damage to the suppression of melatonin," concludes Prof. Haim.

https://www.sciencedaily.com/releases/2017/08/170822103434.htm

Artificial light from digital devices lessens sleep quality

Melatonin skyrockets when blue light is blocked

July 28, 2017

Science Daily/University of Houston

Blue light emitted from digital devices could contribute to the high prevalence of reported sleep dysfunction, suggests new research.

There's no doubt we love our digital devices at all hours, including after the sun goes down. Who hasn't snuggled up with a smart phone, tablet or watched their flat screen TV from the comfort of bed? A new study by researchers at the University of Houston College of Optometry, published in Ophthalmic & Physiological Optics, found that blue light emitted from those devices could contribute to the high prevalence of reported sleep dysfunction.

Study participants, ages 17-42, wore short wavelength-blocking glasses three hours before bedtime for two weeks, while still performing their nightly digital routine. Results showed about a 58 percent increase in their nighttime melatonin levels, the chemical that signals your body that it's time to sleep. Those levels are even higher than increases from over-the-counter melatonin supplements, according to Dr. Lisa Ostrin, the UH College of Optometry assistant professor who lead the study.

"The most important takeaway is that blue light at night time really does decrease sleep quality. Sleep is very important for the regeneration of many functions in our body," Ostrin said.

Wearing activity and sleep monitors 24 hours a day, the 22 study participants also reported sleeping better, falling asleep faster, and even increased their sleep duration by 24 minutes a night, according to Ostrin.

The largest source of blue light is sunlight, but it's also found in most LED-based devices. Blue light boosts alertness and regulates our internal body clock, or circadian rhythm, that tells our bodies when to sleep. This artificial light activates photoreceptors called intrinsically photosensitive retinal ganglion cells (ipRGCs), which suppresses melatonin.

Ostrin recommends limiting screen time, applying screen filters, wearing computer glasses that block blue light, or use anti-reflective lenses to offset the effects of artificial light at nighttime. Some devices even include night mode settings that limit blue light exposure.

"By using blue blocking glasses we are decreasing input to the photoreceptors, so we can improve sleep and still continue to use our devices. That's nice, because we can still be productive at night," Ostrin said.

According to the most recent findings from the National Sleep Foundation's Sleep Health Index®, while three quarters of Americans are satisfied with their sleep over the past week, more than four in ten Americans reported that their daily activities were significantly impacted by poor or insufficient sleep at least once during the past seven days.

https://www.sciencedaily.com/releases/2017/07/170728121414.htm

Mind-body therapies immediately reduce unmanageable pain in hospital patients

July 25, 2017

Science Daily/University of Utah

After participating in a single, 15-minute session of certain mind-body therapies, patients reported an immediate decrease in pain levels similar to what one might expect from an opioid painkiller. This study is the first to compare the effects of mindfulness and hypnosis on acute pain in the hospital setting.

Mindfulness training and hypnotic suggestion significantly reduced acute pain experienced by hospital patients, according to a new study published in the Journal of General Internal Medicine.

After participating in a single, 15-minute session of one of these mind-body therapies, patients reported an immediate decrease in pain levels similar to what one might expect from an opioid painkiller. This study is the first to compare the effects of mindfulness and hypnosis on acute pain in the hospital setting.

The yearlong study's 244 participants were patients at the University of Utah Hospital in Salt Lake City who reported experiencing unmanageable pain as the result of illness, disease or surgical procedures. Willing patients were randomly assigned to receive a brief, scripted session in one of three interventions: mindfulness, hypnotic suggestion or pain coping education. Hospital social workers who completed basic training in each scripted method provided the interventions to patients.

While all three types of intervention reduced patients' anxiety and increased their feelings of relaxation, patients who participated in the hypnotic suggestion intervention experienced a 29 percent reduction in pain, and patients who participated in the mindfulness intervention experienced a 23 percent reduction in pain. By comparison, those who participated in the pain coping intervention experienced a 9 percent reduction. Patients receiving the two mind-body therapies also reported a significant decrease in their perceived need for opioid medication.

"About a third of the study participants receiving one of the two mind-body therapies achieved close to a 30 percent reduction in pain intensity," said Eric Garland, lead author of the study and director of the U's Center on Mindfulness and Integrative Health Intervention Development. "This clinically significant level of pain relief is roughly equivalent to the pain relief produced by 5 milligrams of oxycodone."

Garland's previous research has indicated that multi-week mindfulness training programs can be an effective way to reduce chronic pain symptoms and decrease prescription opioid misuse. This new study added a novel dimension to Garland's work by revealing the promise of brief mind-body therapies for people suffering from acute pain.

"It was really exciting and quite amazing to see such dramatic results from a single mind-body session," said Garland. "Given our nation's current opioid epidemic, the implications of this study are potentially huge. These brief mind-body therapies could be cost-effectively and feasibly integrated into standard medical care as useful adjuncts to pain management."

Garland and his interdisciplinary research team aim to continue studying mind-body therapies as non-opioid means of alleviating pain by conducting a national replication study in a sample of thousands of patients in multiple hospitals around the country.

https://www.sciencedaily.com/releases/2017/07/170725122228.htm

Elderly yoginis have greater cortical thickness

July 13, 2017

Science Daily/Frontiers

Scientists in Brazil have imaged elderly female yoga practitioners' brains and found they have greater cortical thickness in the left prefrontal cortex, in brain areas associated with cognitive functions like attention and memory. The results suggest that yoga could be a way to protect against cognitive decline in old age.

As we age, the structure and functionality of our brains change and this often leads to cognitive decline, including impaired attention or memory. One such change in the brain involves the cerebral cortex becoming thinner, which scientists have shown is correlated with cognitive decline. So, how can we slow or reverse these changes?

You might think medication would be required, but surprisingly, the answer could lie in contemplative practices like yoga. Yoga practitioners consciously maintain postures, and perform breathing exercises and meditation.

"In the same way as muscles, the brain develops through training," explains Elisa Kozasa of Hospital Israelita Albert Einstein in São Paulo, Brazil, a researcher involved in the study, which was recently published in Frontiers in Aging Neuroscience. "Like any contemplative practice, yoga has a cognitive component in which attention and concentration are important."

Previous studies have suggested that yoga can have greater health benefits than similar aerobic exercises, and yoga practitioners have shown improved awareness, attention and memory. Older adults with mild cognitive impairment have also shown improvements after a short yoga training program.

But can practicing yoga over several years significantly shape your brain and if so, could it offset some of the changes that happen in the aging brain? The research team wanted to see if elderly long-term yoga practitioners had any differences in terms of brain structure compared with healthy elderly people who had never practiced yoga.

They recruited 21 female yoga practitioners (also known as yoginis) who had practiced yoga at least twice a week for a minimum of 8 years, although the group had an average of nearly 15 years of yoga practice. The researchers compared the yoginis with another group of 21 healthy women, who had never practiced yoga, meditation or any other contemplative practices, but who were well-matched to the yoginis in terms of their age (all the participants were 60 or over) and levels of physical activity. For more consistent results, the researchers only recruited women, and the participants completed surveys to see if there were any other factors at work that could affect brain structure, such as depression or level of formal education.

The researchers scanned the participants' brains using magnetic resonance imaging to see if there were any differences in brain structure. "We found greater thickness in the left prefrontal cortex in the yoginis, in brain regions associated with cognitive functions such as attention and memory," says Rui Afonso, another researcher involved in the study. As the groups were well-matched in terms of other factors that can change brain structure, such as education and levels of depression, yoga practice appears to underlie the yoginis' different brain structure.

The results suggest that practicing yoga in the long-term can change the structure of your brain and could protect against cognitive decline in old age. However, the team plan to carry out more studies to see if these brain changes result in enhanced cognitive performance in elderly yoginis.

Another possibility is that people with these brain features are more likely to be attracted to yoga. "We have compared experienced yoginis with non-practitioners, so we do not know if the yoginis already had these differences before they started yoga," explains Afonso. "This can only be confirmed by studying people for a few years from the time they start yoga."

https://www.sciencedaily.com/releases/2017/07/170713154922.htm

Mindfulness Meditation Slows Progression of HIV

July 27, 2008

Science Daily/University of California, Los Angeles

CD4+ T lymphocytes, or simply CD4 T cells, are the "brains" of the immune system, coordinating its activity when the body comes under attack. They are also the cells that are attacked by HIV, the devastating virus that causes AIDS and has infected roughly 40 million people worldwide. The virus slowly eats away at CD4 T cells, weakening the immune system.

But the immune systems of HIV/AIDS patients face another enemy as well -- stress, which can accelerate CD4 T cell declines. Now, researchers at UCLA report that the practice of mindfulness meditation stopped the decline of CD4 T cells in HIV-positive patients suffering from stress, slowing the progression of the disease. The study was just released in the online edition of the journal Brain, Behavior, and Immunity.

Mindfulness meditation is the practice of bringing an open and receptive awareness of the present moment to experiences, avoiding thinking of the past or worrying about the future. It is thought to reduce stress and improve health outcomes in a variety of patient populations.

"This study provides the first indication that mindfulness meditation stress-management training can have a direct impact on slowing HIV disease progression," said lead study author David Creswell, a research scientist at the Cousins Center for Psychoneuroimmunology at UCLA. "The mindfulness program is a group-based and low-cost treatment, and if this initial finding is replicated in larger samples, it's possible that such training can be used as a powerful complementary treatment for HIV disease, alongside medications."

"Given the stress-reduction benefits of mindfulness meditation training, these findings indicate there can be health protective effects not just in people with HIV but in folks who suffer from daily stress," Creswell said.

http://www.sciencedaily.com/releases/2008/07/080724215644.htm

Dealing with Stress as a Treatment for Alcohol Abuse

October 28, 2007

Science Daily/University at Buffalo

An addictions researcher is initiating a study of "mindfulness-based stress reduction," a technique often used in behavioral medicine for stress reduction but not before as an adjunct in the treatment of alcohol use disorders.

A researcher at the University at Buffalo's Research Institute on Addictions (RIA) is initiating a study of "mindfulness-based stress reduction," a technique often used in behavioral medicine for stress reduction but not before as an adjunct in the treatment of alcohol use disorders.

"By adapting and applying mindfulness-based stress reduction or MBSR in alcoholism treatment, we hope to develop an increased ability to cope with stress and enhanced psychological well-being among alcohol-dependent individuals," said Gerard J. Connors, Ph.D. "For people who often deal with stress in their lives by turning to alcohol, this could be a very positive alternative."

Connors is a clinical psychologist and principal investigator on the study as well as the director of RIA. He also is a professor in the Department of Psychology in the UB College of Arts and Sciences and research professor in the Department of Psychiatry in the UB School of Medicine and Biomedical Sciences.

The four-year investigation on MBSR will be conducted with support from a $1.9 million grant from the National Institute on Alcohol Abuse and Alcoholism.

The MBSR intervention provides intensive training in mindfulness practices and their applications for daily living and coping with stress. MBSR emphasizes self-observation and self-responsibility, which is expected to facilitate the alcohol-dependent individual's management of the stressors that place the person at increased risk for drinking.

The project will be conducted in two phases, with the first component to include development of an eight-session treatment manual for conducting group-based MBSR with alcohol-dependent men and women. In phase two, a pilot clinical trial will be conducted to examine the effects of adding MBSR to outpatient treatment. 

The long-term goal is to decrease relapse to drinking following treatment, thereby providing significant health benefits to people being treated for alcohol dependence, with corresponding benefits for their families and the community-at-large.
http://www.sciencedaily.com/releases/2007/10/071026162329.htm

Mindfulness Meditation: A New Treatment for Fibromyalgia?

August 6, 2007

Science Daily/Psychotherapy and Psychosomatics

Fibromyalgia has emerged as a common, yet difficult to treat disorder. A group of investigators has proposed a new modality of treatment. Mindfulness-based stress reduction (MBSR) proposes a systematic program for reduction of suffering associated with a wide range of medical conditions.

Studies suggest improvements in general aspects of well-being, including quality of life (QoL), coping and positive affect, as well as decreased anxiety and depression. A quasi-experimental study examined effects of an 8-week MBSR intervention among 58 female patients with fibromyalgia (mean, 52 ± 8 years) who underwent MBSR or an active social support procedure.

Three-year follow-up analyses of MBSR participants indicated sustained benefits for these same measures (effect size, 0.50-0.65). Based upon a quasi-randomized trial and long-term observational follow-up, results indicate mindfulness intervention to be of potential long-term benefit for female fibromyalgia patients.

http://www.sciencedaily.com/releases/2007/08/070805134742.htm