Past your bedtime? Inconsistency may increase risk to cardiovascular health

March 24, 2020

Science Daily/University of Notre Dame

Researchers found that individuals going to bed even 30 minutes later than their usual bedtime presented a significantly higher resting heart rate that lasted into the following day.

Despite increasing awareness of how critical sleep is to our health, getting a good night's rest remains increasingly difficult in a world that's always "on" -- responding to emails at all hours, news cycles that change with every tweet and staring endlessly into the blue light of cell phone, tablet and computers screens.

Scientists have stressed the importance of healthy sleep habits, recommending at least seven hours each night, and have linked lack of sleep to an increased risk in numerous health conditions, including diabetes, stroke and cardiovascular disease.

Now a new study shows whether or not you go to bed on time could also have an effect on your health. Researchers at the University of Notre Dame studied the correlation between bedtime regularity and resting heart rate (RHR) and found that individuals going to bed even 30 minutes later than their usual bedtime presented a significantly higher resting heart rate that lasted into the following day.

"We already know an increase in resting heart rate means an increased risk to cardiovascular health," said Nitesh Chawla, the Frank M. Freimann professor of Computer Science and Engineering at Notre Dame, director of the Center for Network and Data Science and a lead author of the study. "Through our study, we found that even if you get seven hours of sleep a night, if you're not going to bed at the same time each night, not only does your resting heart rate increase while you sleep, it carries over into the next day."

Chawla and his team analyzed data collected via Fitbit from 557 college students over the course of four years. They recorded 255,736 sleep sessions -- measuring bedtimes, sleep and resting heart rate. Significant increases in RHR were observed when individuals went to bed anywhere between one and 30 minutes later than their normal bedtime. Normal bedtime was defined as the one-hour interval surrounding a person's median bedtime. The later they went to bed, the higher the increase in RHR. Rates remained elevated into the following day.

Surprisingly, going to bed earlier than one's standard bedtime also showed signs of increasing RHR, though it depended on just how early. Going to bed 30 minutes earlier than usual appeared to have little effect, while going to bed more than a half hour earlier significantly increased RHR. In cases of earlier bedtimes, however, RHR leveled out during the sleep session. Circadian rhythms, medications and lifestyle factors all come into play when it comes to healthy sleep habits, but Chawla said it's vital to consider consistency as well.

"For some, it may be a matter of maintaining their regular 'work week' bedtime through the weekend," said Chawla. "For shift workers and those who travel frequently, getting to bed at the same time each night is a challenge. Establishing a healthy bedtime routine -- as best you can -- is obviously step number one. But sticking to it is just as important."

https://www.sciencedaily.com/releases/2020/03/200324131818.htm

Music as medicine? 30 minutes a day shows benefits after heart attack

Daily music sessions found to reduce anxiety, pain and subsequent heart problems

March 18, 2020

Science Daily/American College of Cardiology

Listening to music can be enjoyable, but is it also good for your heart? Patients who suffered episodes of chest pain soon after a heart attack, known as early post-infarction angina, had significantly lower levels of anxiety and pain if they listened to music for 30 minutes a day, according to a study presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

Nearly 700,000 people survive a heart attack in the U.S. each year, and it is estimated that roughly 1 in 9 heart attack survivors experience subsequent episodes of chest pain and anxiety within the first 48 hours. The new research suggests music, combined with standard therapies such as medications, could be a simple, accessible measure that patients can do at home to potentially reduce these symptoms and help prevent subsequent cardiac events.

"There have been very few studies analyzing the effects of music on heart conditions," said Predrag Mitrovic, MD, PhD, professor of cardiology at the University of Belgrade School of Medicine and the study's lead author. "Based on our findings, we believe music therapy can help all patients after a heart attack, not only patients with early post-infarction angina. It's also very easy and inexpensive to implement."

The researchers recruited 350 patients diagnosed with heart attack and early post-infarction angina at a medical center in Serbia. Half were randomly assigned to receive standard treatment while half were assigned to regular music sessions in addition to standard treatment. For most patients, standard treatment included a variety of medications such as nitrates, aspirin, clot-preventing drugs, beta blockers, statins, calcium channel blockers, blood pressure-lowering medications and the angina-reducing drug ranolazine.

Patients receiving music therapy first underwent a test to determine which musical genre their body was likely to respond to positively. Participants listened to nine 30-second samples of music they found soothing, while researchers assessed each participant's body for automatic, involuntary responses to the music samples based on dilation or narrowing of the pupils. Researchers then fine-tuned the selection by working with the patient to determine the optimal music tempo and tonality.

Participants were asked to listen to their designated musical selection for 30 minutes each day whenever it was convenient for them to sit, ideally while resting with their eyes closed. Patients continued with these daily listening sessions for seven years, documenting their sessions in a log. They returned to the medical center for follow-up assessments every three months for the first year and annually thereafter.

At the end of seven years, music therapy was found to be more effective than standard treatment alone in terms of reducing anxiety, pain sensation and pain distress. The patients with music therapy, on average,

had anxiety scores one-third lower than those on standard treatment and reported lower angina symptoms by about one-quarter. These patients also had significantly lower rates of certain heart conditions, including an 18% reduction in the rate of heart failure; 23% lower rate of subsequent heart attack; 20% lower rate of needing coronary artery bypass graft surgery; and 16% lower rate of cardiac death.

Mitrovic said the music may work by helping to counteract the activity of the sympathetic nervous system, the part of the nervous system that drives the "fight-or-flight" response when a person faces a stressful situation. Because it increases heart rate and blood pressure, a sympathetic response can put added strain on the cardiovascular system.

"Unrelieved anxiety can produce an increase in sympathetic nervous system activity, leading to an increase in cardiac workload," Mitrovic said. He suggested regular sessions of listening to music could interrupt that cascade of events by reducing the anxiety associated with angina after a heart attack.

The researchers plan to further analyze the data to determine whether music therapy may show benefits for certain subgroups of patients, such as those in a certain age range or those with other health conditions like diabetes.

https://www.sciencedaily.com/releases/2020/03/200318104453.htm

Getting too little -- or too much -- sleep may be bad for the heart

Clocking seven or eight hours of shut eye a night seems to be sweet spot for heart health

March 18, 2020

Science Daily/American College of Cardiology

Whether you like to burn the midnight oil to check emails or binge watch your favorite series, toss and turn or sleep until mid-morning, it seems the amount of sleep you get matters when it comes to your future vascular and heart health. Compared with people who slept for longer or shorter periods of time, those who reported sleeping seven or eight hours a night had significantly less evidence of stiffness in their arteries, indicating a lower chance of developing heart disease or suffering a stroke, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).

Even after accounting for other known risk factors for heart disease or stroke, people who slept less than six hours or more than eight hours a night had significantly greater odds of having plaque buildup in the walls of their carotid arteries -- a 54% and 39% increase, respectively -- compared with those who got seven or eight hours of shut eye. The study adds to mounting evidence that sleep patterns, similar to diet and exercise, may play a defining role in someone's cardiovascular risk.

"The message, based on our findings, is 'sleep well, but not too well.' Getting too little sleep appears bad for your health but too much seems to be harmful as well," said Evangelos Oikonomou, MD, consultant cardiologist and the study's lead author. "Unlike other heart disease risk factors such as age or genetics, sleep habits can be adjusted, and even after taking into consideration the impact of established risk factors for atherosclerosis and cardiovascular diseases -- for example age, gender, obesity, smoking, hypertension, diabetes, high blood pressure and even a history of coronary artery disease -- both short and long sleeping duration may act as additional risk factors."

For this analysis, researchers assessed sleep patterns in 1,752 people living in the Corinthia region of Greece using a standard questionnaire that was fielded by a trained cardiologist, primary care provider or nurse. Participants were then divided into one of four groups based on self-reported sleep duration: normal (seven to eight hours a night), short sleep duration (six to seven hours a night), very short sleep duration (less than six hours a night) or long sleep duration (greater than eight hours a night). Participants represented a broad spectrum of the general public, including healthy people as well as those with cardiovascular risk factors and established heart disease, and most were from rural areas with less than 1,000-2,000 inhabitants. They ranged in age from 40 to 98 years, with a mean age of 64 years old.

At the time of the study, each participant also underwent ultrasound imaging to measure the thickness of the inner part of the arterial wall. Thickening of the arterial walls reflects plaque buildup and is associated with an increased risk of stroke and other cardiovascular events. Intima media thickness of >1.5 mm or protrusion >50% compared to nearby segments of the artery wall was defined as atherosclerotic plaque.

Researchers uncovered a U-shaped pattern between sleep duration and early indicators of atherosclerosis, which underscores the need for a balanced sleep pattern, Oikonomou said. Intima media thickness and plaque build-up in the artery walls was greater in both the shorter and longer sleep duration groups as compared to normal sleep duration.

"We don't fully understand the relationship between sleep and cardiovascular health. It could be that sympathetic nervous system withdrawal or a slowing [of this system] that occurs during sleep may act as a recovery phase for [usual] vascular and cardiac strain," Oikonomou said. "Moreover, short sleep duration may be associated with increased cardiovascular risk factors -- for example, unhealthy diet, stress, being overweight or greater alcohol consumption -- whereas longer sleep duration may be associated with a less active lifestyle pattern and lower physical activity."

Researchers said that adopting a balanced sleep pattern of six to eight hours nightly may be just what the doctor ordered.

"It seems that this amount of sleep may act as an additive cardioprotective factor among people living in modern western societies, and there can be other health benefits to getting sufficient and quality sleep," Oikonomou added.

The amount of sleep someone needs depends on several factors, especially one's age. In the U.S., most guidelines recommend that adults sleep between seven and nine hours each night. Yet, one out of every three American adults do not get enough sleep, according to the Centers for Disease Control and Prevention. Poor sleep has also been linked to a higher risk of obesity, diabetes, high blood pressure, heart disease, poor mental health and even dying early.

This study is limited in that it relies on self-reported sleep patterns and is cross sectional in nature, so the relationship between sleep patterns and atherosclerotic activity is based on a single point in time. Further research is needed, especially to look at whether too much sleep is harmful, which hasn't been studied as well as getting too little.

https://www.sciencedaily.com/releases/2020/03/200318104451.htm

Heavy stress and lifestyle can predict how long we live

March 11, 2020

Science Daily/National Institute for Health and Welfare

Life expectancy is influenced not only by the traditional lifestyle-related risk factors but also by factors related to a person's quality of life, such as heavy stress. The biggest causes for shortened life expectancy for 30-year-old men are smoking and diabetes. Smoking takes 6.6 years and diabetes 6.5 years out of their life expectancy. Being under heavy stress shortens their life expectancy by 2.8 years.

These results are based on a study in which researchers from the Finnish Institute for Health and Welfare calculated the effects of multiple risk factors, including lifestyle-related ones, to the life expectancy of men and women.

The study also revealed that a lack of exercise strongly reduced the life expectancy of 30-year-old men -- by 2.4 years. On the other hand, things such as the consumption of plenty of fruits and vegetables could increase life expectancy: eating fruit by 1.4 years and eating vegetables by 0.9 years.

The same factors impacted the life expectancy of both men and women. For 30-year-old women, e.g. smoking shortened the life expectancy by 5.5 years, diabetes by 5.3 years, and heavy stress by 2.3 years.

The effects to the life expectancy of older people were similar but smaller than in younger age groups.

The golden middle seemed to have the most positive effect in some factors related to lifestyle. The experience of stress increased the life expectancy if the person felt the amount of stress they had was approximately the same as what other people typically experienced. Having more or less stress than that, on the other hand, reduced their life expectancy.

A new calculation method in use for a large group of risk factors for the first time

The study was based on data collected from men and women aged 25 to 74 in the Finnish National FINRISK Study 1987-2007 through questionnaires and measurements. The rate of mortality was followed until the end of 2014.

The researchers calculated the life expectancies by changing the values of each risk factor at a time and keeping the values of other factors constant. Only the BMI, blood pressure, and cholesterol levels were allowed to be changed when the values related to lifestyle factors were changed.

"Before, life expectancy has usually been assessed based on only a few sociodemographic background factor groups, such as age, sex, and education. In this study, we wanted to assess the impact of several different factors to a person's life expectancy, so we could compare their effects," says Research Manager Tommi Härkänen.

Differences between the life expectancies of men and women largely due to risk factors that can be changed

"What was interesting about the study was how small the difference in the life expectancy of 30-year men and women was based on the same risk factor values -- only 1.6 years. According to the statistics from Statistics Finland, the difference between the sexes has been over five years for all 30-year-olds, which comes down to women having healthier lifestyles than men," says Research Professor Seppo Koskinen.

In this study, the differences in the life expectancies of people with different levels of education were fairly small when the other risk factor values were the same. However, earlier studies have discovered large differences between the life expectancies of groups of people with different levels of education.

The lifestyle choices that increase mortality, such as smoking, heavy alcohol use, unhealthy diet, and lack of exercise, are most common in the population groups whose social position is the weakest.

The life expectancy of the whole population could be improved significantly through helping men and people with a lower level of education, in particular, make better lifestyle choices.

https://www.sciencedaily.com/releases/2020/03/200311100857.htm

Gratitude interventions don't help with depression, anxiety

Being grateful has benefits, but not for these issues

March 9, 2020

Science Daily/Ohio State University

Go ahead and be grateful for the good things in your life. Just don't think that a gratitude intervention will help you feel less depressed or anxious.

In a new study, researchers at The Ohio State University analyzed results from 27 separate studies that examined the effectiveness of gratitude interventions on reducing symptoms of anxiety and depression.

The results showed that such interventions had limited benefits at best.

"For years now, we have heard in the media and elsewhere about how finding ways to increase gratitude can help make us happier and healthier in so many ways," said David Cregg, lead author of the study and a doctoral student in psychology at Ohio State.

"But when it comes to one supposed benefit of these interventions -- helping with symptoms of anxiety and depression -- they really seem to have limited value."

Cregg conducted the study with Jennifer Cheavens, associate professor of psychology at Ohio State. Their results were published online recently in the Journal of Happiness Studies.

There are two commonly recommended gratitude interventions, Cheavens said. One is the "Three Good Things" exercise: At the end of the day, a person thinks of three things that went well for them that day, then writes them down and reflects on them.

Another is a "gratitude visit," when a person writes a letter thanking someone who has made a difference in their life and then reads the letter to that person.

The 27 studies involved in this analysis often had participants do one of these exercises or something similar. The studies included 3,675 participants.

In many studies, participants who did the gratitude interventions were compared with people who performed a similar activity that was unrelated to gratitude. For example, instead of writing about what they were grateful about, a college student sample might write about their class schedule.

The gratitude intervention was not much better at relieving anxiety and depression than the seemingly unrelated activity.

"There was a difference, but it was a small difference," Cheavens said. "It would not be something you would recommend as a treatment."

As an alternative, Cheavens and Cregg recommend people pursue treatments that have been shown to be effective with anxiety and depression, such as cognitive behavioral therapy.

The results suggest that it isn't helpful to tell people with symptoms of depression or anxiety to simply be more grateful for the good things they have, Cheavens said.

"Based on our results, telling people who are feeling depressed and anxious to be more grateful likely won't result in the kind of reductions in depression and anxiety we would want to see," she said.

"It might be that these sort of interventions, on their own, aren't powerful enough or that people have difficulty enacting them fully when they are feeling depressed and anxious."

The results don't mean that there are no benefits to being grateful or to using gratitude interventions, the researchers said. In fact, some studies show that such interventions are effective at improving relationships.

"It is good to be more grateful -- it has intrinsic virtue and there's evidence that people who have gratitude as a general trait have a lower incidence of mental health problems and better relationships," Cregg said.

"The problem is when we try to turn gratefulness into a self-help tool. Gratitude can't fix everything."

https://www.sciencedaily.com/releases/2020/03/200309130010.htm

Spending on experiences versus possessions advances more immediate happiness

March 9, 2020

Science Daily/University of Texas at Austin

Consumers are happier when they spend their money on experiential purchases versus material ones, according to new research.

Certain purchases are better than others at sparking people's in-the-moment happiness, according to new research from the McCombs School of Business at The University of Texas at Austin.

Lead author Amit Kumar, assistant professor of marketing, and his research team found that consumers are happier when they spend on experiential purchases versus material ones. The paper, "Spending on Doing Promotes More Moment-to-Moment Happiness than Spending on Having," is published in the May 2020 issue of the Journal of Experimental Social Psychology.

"One issue that hasn't really been examined much is what happens in the here and now -- are we happier spending our money on an experience or on a material item?" Kumar said. "The basic finding from a lot of experiments is that people derive more happiness from their experiences than from their possessions."

Kumar and his co-authors, Matthew Killingsworth from the University of Pennsylvania, and Thomas Gilovich from Cornell University, recruited 2,635 adults who were randomly assigned to a material or experiential group. The participants were sent random texts during the day to monitor their emotions and their purchasing behavior. Material purchasers bought things such as jewelry, clothing or furniture, while experiential shoppers attended sporting events, dined at restaurants, or engaged in other experiences. The results: Happiness was higher for participants who consumed experiential purchases versus material ones in every category, regardless of the cost of the item.

"It would be unfair to compare a shirt to a trip, but when we account for price, we still see this result where experiences are associated with more happiness," Kumar said.

To address possible differences in types of consumers, the researchers conducted a second study in which they asked more than 5,000 participants to first rate their happiness and then report whether they had used, enjoyed, or consumed either a material or experiential purchase within the past hour. If they responded "yes," participants were asked a series of questions and details about their purchase.

"We still observed the same effect," Kumar said. "When the very same person was consuming an experience, that was associated with more happiness."

The researchers concluded that people are happier with experiential purchases over material ones irrespective of when you measure happiness: before, during or after consumption. Experiences also provoke more satisfaction even though people typically spend more time using their material possessions. The researchers said a possible explanation is the endurance of experiences in people's memories, while the perceived value of material goods weakens over time.

"If you want to be happier, it might be wise to shift some of your consumption away from material goods and a bit more toward experiences," Kumar said. "That would likely lead to greater well-being."

https://www.sciencedaily.com/releases/2020/03/200309130020.htm

Study reveals positive connection between nature experiences and happiness

Analysis of 31,500 photographs across 185 countries showed that images of fun activities and vacations are more likely to contain elements of nature

March 10, 2020

Science Daily/National University of Singapore

An AI analysis of photographs posted on social media revealed a positive association between nature and happiness globally.

The economic and ecological impact of nature on humans have long been established with prevalent environmental issues such as climate change and over-exploitation of natural resources being the first to cross one's mind. On the other hand, much less attention has been paid to the cultural and social values nature brings to humans. Even though natural wonders such as the Great Barrier Reef and the Swiss Alps have been named some of the top holiday destinations, the intangible benefits people gain from experiencing nature are still difficult to quantify, and such studies typically require resource-intensive surveys and interviews.

In order to evaluate the benefits of nature experiences more efficiently and effectively, a team of researchers from the National University of Singapore (NUS) turned to social media and artificial intelligence (AI) in a study published in Scientific Reports on 5 March 2020.

Led by Associate Professor Roman Carrasco and Dr Chang Chia-chen from the Department of Biological Sciences at NUS Faculty of Science, the research team analysed over 31,500 photographs across 185 countries on social media with the help of an automated image recognition technology.

"Integrating social media data and AI opens up a unique opportunity for us to carry out unprecedented large-scale global studies such as this to better understand our interactions with nature in our daily lives," said Dr Chang, Research Fellow at the Department of Biological Sciences at NUS Faculty of Science and first author of the study.

The team's analysis of the photographs uploaded on social media revealed that photographs tagged as #fun, #vacations and #honeymoons are more likely to contain elements of nature such as plants, water and natural landscape as compared to photographs tagged #daily or #routines. This finding, which is consistent across different countries, provides global evidence of biophilia hypothesis -- human's innate tendency to seek connection with nature -- and implies a positive association between nature and fond memories in memorable events like honeymoons.

The team also found that the amount of nature experiences in a country is linked to the life satisfaction of its residents. Countries which have more elements of nature in photographs tagged as #fun such as Costa Rica and Finland, for instance, possess higher llfe national satisfaction scores according to scores reported in the World Happiness Report 2019. Collectively, the findings suggest the importance of nature in contributing to emotional happiness, relaxation and life satisfaction in communities worldwide.

Assoc Prof Carrasco said, "Our study brings to light the cultural and social values that nature brings to humans. It further emphasises the importance of preserving our natural environment for the loss of nature may mean more than losing quantifiable economic and ecological benefits; it could also mean losing the background to our fondest memories."

"Our next step is therefore to establish how nature experiences may benefit human well-being such as how it improves our satisfaction in life, hence enabling the development of constructive solutions to better environmental conservation," he added.

https://www.sciencedaily.com/releases/2020/03/200310094227.htm

Third-hand smoke is no joke, can convey hazardous chemicals

March 5, 2020

Science Daily/Yale University

People can carry hazardous compounds from cigarette smoke that cling to their bodies and clothes and then release those compounds into non-smoking environments -- exposing people nearby to cigarettes' adverse effects, a new study shows.

For the last decade, third-hand smoke has been described as the residual contamination from cigarette smoking that adheres to walls and other surfaces in places where smoking has previously occurred. For example, hotels and rental car companies have implemented smoking restrictions to limit this contaminating odor from their rooms and cars.

A team of researchers led by Yale's Drew Gentner shows for the first time that this third-hand smoke can travel in large quantities into indoor, non-smoking environments by way of humans. The research suggests that even if someone is in a room where no one has smoked, that person could still be exposed to many of the hazardous chemical compounds that make up cigarette smoke, depending on who else had entered the room or previously visited it. The results were published March 4 in Science Advances.

"In real-world conditions, we see concentrated emissions of hazardous gases coming from groups of people who were previously exposed to tobacco smoke as they enter a non-smoking location with strict regulations against indoor smoking," said Gentner, associate professor of chemical & environmental engineering. "People are substantial carriers of third-hand smoke contaminants to other environments. So, the idea that someone is protected from the potential health effects of cigarette smoke because they're not directly exposed to second-hand smoke is not the case."

The researchers brought highly sensitive analytical instrumentation into a movie theater to track thousands of compounds, present as either gases or particles, over the course of a week. A diverse range of volatile organic compounds found in tobacco smoke spiked dramatically when certain audiences arrived for the movies. These increases were minor for G-rated movies, while audiences for R-rated movies -- which included moviegoers more likely to smoke or to be exposed to smoke -- consistently released much larger quantities of these compounds into the theater. The relative proportions of these emitted compounds confirmed that they were from slightly aged cigarette smoke.

"Despite regulations preventing people from smoking indoors, near entryways, and near air intakes, hazardous chemicals from cigarette smoke are still making their way indoors," said Roger Sheu, a Ph.D. student in Gentner's lab and lead author of the study.

The amount of these hazardous and reactive gases wasn't trivial, the researchers said. The gas emissions were equal to that of being exposed to 1-10 cigarettes of secondhand smoke in a one-hour period. These emissions and air concentrations peaked upon audience arrival and decreased over time, but not completely, even when the audiences left. In many cases, the movie-goers left a persistent contamination observable the following days in the unoccupied theater. The researchers said that is because the chemicals don't remain entirely in the air, but are also adsorbed onto various surfaces and furnishings, just as it does with third-hand smoke contamination in places where smoking has occurred.

The researchers also found a predominance of nitrogen-containing compounds from cigarettes, which would have migrated from people to other indoor surfaces.

"In particular, we noticed that nicotine was the most prominent compound by far," said co-author Jenna Ditto, a Ph.D. student in Gentner's lab.

The researchers said these results on human transport of third-hand smoke now help to explain why previous studies had found notable quantities of nicotine on surfaces in numerous non-smoking environments.

The researchers emphasized that avoiding movie theaters is not the solution to avoiding third-hand smoke. In fact, the theater used for the study is modern, large, and well-ventilated, which reduced the effect of the emissions on concentrations of hazardous compounds in the room. In less well-ventilated spaces -- such as public transit, bars, offices, and homes -- similar third-hand smoke emissions would likely result in considerably higher concentrations of many of these compounds.

https://www.sciencedaily.com/releases/2020/03/200305002859.htm

Microbiome species interactions reveal how bacteria collaborate to cheat death

Antibiotics set up a multi-faceted experiment in your gastrointestinal system

March 5, 2020

Science Daily/Carnegie Institution for Science

When a doctor prescribes antibiotics, it sets up a multi-faceted experiment in your gastrointestinal system. What can this teach us about the molecular principles of species interactions in nature? New work set out to answer this challenging question and discovered a new form of antibiotic tolerance.

Antibiotics can make easy work of infections. But how do they affect the complex ecosystems of friendly bacteria that make up our microbiome?

"When a doctor prescribes antibiotics, it sets up a multi-faceted experiment in your gastrointestinal system," explains Carnegie's Will Ludington "What can this teach us about the molecular principles of species interactions in nature?"

New work led by Ludington and Stanford University's K.C. Huang set out to answer this challenging question and discovered a new form of antibiotic tolerance. Their findings, which have important health implications, are published by eLife.

This is one of several research fronts on which Ludington uses the fruit fly microbiome to understand interactions between species in a bacterial community. It poses an ideal environment for probing both natural bacterial populations and the human microbiome.

The human microbiome is an ecosystem of hundreds to thousands of microbial species living within our guts. It affects our health and even our longevity. But it's difficult to elucidate the myriad ways that the different species that comprise our microbiome interact with and influence each other, even under normal conditions. Once antibiotics are introduced, little is understood about how these vital communities are impacted on a biochemical level.

This is why the fruit fly makes such an excellent model. Unlike the human microbiome, it consists of only a handful of bacterial species.

"We really wanted to understand how an antibiotic's targeting of specific physiological processes impacts the metabolic interactions and sharing of resources that occurs between bacterial species within a community," said lead author Andrés Aranda-Díaz of Stanford. "This is especially important because in nature bacteria live in diverse communities."

The simplicity of the fruit fly microbiome makes it the perfect vehicle for revealing how this multi-species biochemical interplay is altered by the introduction of antibiotics.

"We found that interactions between species in the gut microbiome ecosystem influence the effectiveness of antibiotics at killing off an individual species within this community, as well as the entire community's metabolism," said Huang.

The researchers demonstrated that when a type of bacterium from the fruit fly microbiome, called Lactobacillus -- which are also found in yogurt -- is grown together with a vinegar-producing fly bacterium called Acetobacter, it is less susceptible to death by antibiotics.

This is a newfound category of a phenomenon called antibiotic tolerance, meaning that cells die much more slowly when found together than they would on their own. Tolerance can be dangerous, because this delay increases the risk that full-on resistance to the antibiotic could evolve.

"Normally, tolerance occurs when a cell slows its metabolism in response to antibiotic exposure," explained Ludington. "But in this case, the tolerance is actually associated with increased metabolism."

It turns out that the Acetobacters consume the lactic acid that is excreted as a waste product by neighboring Lactobacillus, providing a fitness advantage to both species and triggering the tolerance the team discovered.

"We don't know exactly how it happens yet, but we think the two bacterial species both 'know' when the other type of cell is there and respond appropriately," said Benjamin Obadia of UC Berkeley. "These mechanisms are probably evolved from living together, and we wouldn't have seen them if we studied the two species in isolation."

The team's work shows that the microbiome can be an important tool for understanding the relationships within communities of bacteria in the natural world on a biochemical level.

"It also illustrates that gut microbiome health should be considered whenever antibiotics are prescribed," added Ludington.

Studying the principles governing species-species interactions are key to understanding so much about ecosystems large and small and the microbiome is a critical tool for exploring these questions.

Another recently published collaboration between Ludington, Huang, and a different Stanford researcher -- biologist Lucy O'Brien -- developed new technology to visualize the guts of living fruit flies. Called Bellymount, it allowed them to observe individual bacterial cells in the gut of a living fruit fly for the first time.

"By observing the microbiome in real time, we were able to measure its dynamics," said Ludington of their paper, which appeared in PLOS Biology.

The research team found that specific regions of the gut have high microbiome stability and others have continuous turnover. This indicates that there are structures in the fruit fly gut that maintain colonization and opens the door to the possibility that fruit flies may have evolved these structures to keep their microbiomes.

"Now we have the power to actually eavesdrop on the 'conversations' occurring between microbiome bacteria, and the gut cells in their surrounding environment," said Huang

This work was supported by the NIH, the U.S. NSF, the Allen Center for Systems Modeling of Infection, Chan Zuckerberg, the Howard Hughes Medical Institute, and Stanford University's Bio-X.

https://www.sciencedaily.com/releases/2020/03/200305132019.htm

Air pollution is one of the world's most dangerous health risks

March 5, 2020

Science Daily/Max-Planck-Gesellschaft

Researchers calculate that the effects of air pollution shorten the lives of people around the world by an average of almost three years.

Polluted air is a public health hazard that cannot be evaded. It is widely known that long-term exposure to air pollution enhances the risks of cardiovascular and respiratory diseases. Scientists from the Max Planck Institute for Chemistry and the University Medical Center Mainz now calculated in a new study that the global, public loss of life expectancy caused by air pollution is higher than many other risk factors such as smoking, infectious diseases or violence.

Air pollution caused 8.8 million premature deaths worldwide in 2015. This corresponds to an average reduction in life expectancy per capita of 2.9 years. In comparison, tobacco smoking reduces the life expectancy by an average of 2.2 years (7.2 million deaths), HIV / AIDS by 0.7 years (1 million deaths), parasitic and vector-borne diseases such as malaria -- by 0.6 years (600,000 deaths). "Air pollution exceeds malaria as a cause of premature death by a factor of 19; it exceeds violence by a factor of 17 and HIV / AIDS by a factor of 9. Given the huge impact on public health and the global population, one could say that our results indicate an air pollution pandemic," said Jos Lelieveld, director at Max Planck Institute for Chemistry and first author of the study.

This study is the first to examine the global impact of air pollution on human health compared to other risk factors worldwide. "Our comparison of different global risk factors shows that ambient air pollution is a leading cause of premature mortality and loss of life expectancy, in particular through cardiovascular diseases," says Thomas Münzel, director of the Cardiology Center at the University Medical Center in Mainz and co-author of the paper.

Relationship between pollution and disease

The scientists examined the connection between exposure to pollutants and the occurrence of diseases. In order to calculate the worldwide exposure to pollutants, which primarily include fine particles and ozone, the researchers used an atmospheric chemical mode. They then combined the exposure data with the Global Exposure -- Mortality Model that derives from many epidemiological cohort studies. Using these tools and data, scientists investigated the effects of different pollution sources, distinguishing between natural (wildfires, aeolian dust) and anthropogenic emissions, including fossil fuel use. Based on their results they could estimate the disease-specific excess mortality and loss of life expectancy in all countries world-wide.

The study results show that the mortality caused by ambient air pollution is highest in East Asia (35 percent) and South Asia (32 percent), followed by Africa (11 percent), Europe (9 percent) and North- and South America (6 percent). Lowest mortality rates are found in Australia (1,5 percent) associated with the strictest air quality standards of all countries. "We understand more and more that fine particles primarily favor vascular damage and thus diseases such as heart attack, stroke, cardiac arrhythmia and heart failure. It is of outmost importance that air pollution is adopted as a cardiovascular risk factor and that it is distinctly mentioned in the ESC/AHA guidelines of prevention, acute and coronary syndromes and heart failure," continued Münzel.

Avoidable deaths

According to the findings of the study, almost two thirds of the deaths caused by air pollution, namely around 5.5 million a year are avoidable, and the majority of polluted air comes from the use of fossil fuels. The researchers estimate that the average life expectancy world-wide would increase by more than a year if the emissions from the use of fossil fuels were eliminated.

The team from the University Medical Center Mainz and Max Planck Institute for Chemistry published a similar paper last year focusing on the consequences of air pollution in Europe. According to the earlier study, nearly 800,000 Europeans die prematurely every year due to illnesses caused by air pollution. Polluted air shortens the lifespan of Europeans by more than two years.

https://www.sciencedaily.com/releases/2020/03/200305135048.htm

In US, changing self-concept can lower well-being

Americans value freedom, but not the freedom to change who they are

March 3, 2020

Science Daily/University of Georgia

American culture values the freedom to change and reinvent one's self. A new study, however, reveals that Americans who do change tend to report a lower sense of well-being.

University of Georgia psychologists compared individual self-concepts between Americans and Japanese counterparts and uncovered this essential contradiction about the heroic myth of American individualism.

The findings were published in the journal Social Psychological and Personality Science.

"In Western and particularly American culture there is a notion that we have a lot of freedom, and that you can reinvent yourself and that's a positive thing," said Brian Haas, associate professor in the Franklin College of Arts and Sciences department of psychology and lead author on the new study. "But when you apply it to one's self-concept and reinventing one's self, are they better off? Are they happier than people who do not change? We found that it's not the case."

The researchers sourced publicly available longitudinal self-reported personality data from the United States and Japan, and found that in the United States, any type of self-concept changes occurring over the course of several years tended to be associated with a marked decrease in well-being. Conversely Japanese respondents did not show a similar link between self-concept changes and decreased well-being. Self-concept refers to how individuals think about their identity.

"One way to think about this is in political debates, where one of the worst things you can call somebody out on in the United States is being a flip-flopper," Haas said. "Changing your mind, and not being consistent, tends to be thought of as a very negative characteristic in the United States political culture. We found that when people change their identity and likely change their minds, there are many profound negative consequences in our culture."

These notions contrast sharply with cultures such as Japan that tend to have an interdependent identity within a relatively collective culture.

"Changes are perceived as being adaptable in an interdependent context. Social relationships are stronger, concrete, and don't change so quickly. And one way to ensure harmony in those strong social relationships is to be adaptable and flexible so you can make sure that the social relationship remains positive," Haas said.

Individual liberty and self-reinvention may be promoted as a good thing in the U.S., but American people who change tend to be worse off than those that remain consistent.

"In the United States, people who are being inconsistent, experience lower well-being, report that they are less happy, have less meaning in life and have poorer relationships with their family members."

Self-reported emotions and emotional experience in Japan, their sense of value and meaning in life, and also the strength of relationships within families suggest that more stable Japanese culture can withstand changes in individual self-concept.

Even Americans who were changing in a socially desirable direction -- becoming, for example, more conscientious, or more extroverted -- were not experiencing positive consequences in terms of their well-being.

"It's all negative -- any type of change in any direction in the U.S. tended to be linked to negative well-being," Haas said.

Individualism is strongly characterized by behavior in social scenarios, with freedom to choose friends, romantic partners, and the freedom to leave our hometown and family.

"That sense of freedom might mean we don't need to keep those relationships in check, and that's likely what is contributing to this effect. Americans do not need to be adaptable to be able keep their social relationships consistent and positive, because we can just start new relationships or opt out of them easily, we have the freedom to be able to do so," said Michelle vanDellen, associate professor and co-author of the study.

"In the United States, we have a strong tendency to hold up on a pillar those that remain consistent and don't change their identity or minds. It's really something we hold as a high value here," Haas said.

https://www.sciencedaily.com/releases/2020/03/200303175315.htm

The world faces an air pollution 'pandemic'

People's lives are shortened by an average of nearly three years from different sources of air pollution

March 2, 2020

Science Daily/European Society of Cardiology

Air pollution is responsible for shortening people's lives worldwide on a scale far greater than wars and other forms of violence, parasitic and insect-born diseases such as malaria, HIV/AIDS and smoking, according to a new study.

Professors Jos Lelieveld and Thomas Münzel, of the Max Planck Institute for Chemistry and the Department of Cardiology of the University Medical Centre Mainz in Mainz, Germany, who led the research, say the findings suggest the world is facing an air pollution "pandemic."

Using a new method of modelling the effects of various sources of air pollution on death rates, the researchers estimated that globally air pollution caused an extra 8.8 million premature deaths a year in 2015. This represents an average shortening of life expectancy of nearly three years for all persons worldwide.

In comparison, tobacco smoking shortens life expectancy by an average of 2.2 years (7.2 million deaths), HIV/AIDS by 0.7 years (1 million deaths), diseases like malaria that are carried by parasites or insects such as mosquitoes, ticks and fleas by 0.6 years (600,000 deaths), and all forms of violence (including deaths in wars) by 0.3 years (530,000 deaths). 

The researchers looked at the effect of air pollution on six categories of disease: lower respiratory tract infection, chronic obstructive pulmonary disease, lung cancer, heart disease, cerebrovascular disease leading to stroke, and other, non-communicable diseases, which include conditions such as high blood pressure and diabetes. They found that cardiovascular diseases (heart disease and cerebrovascular disease combined) are responsible for the greatest proportion of shortened lives from air pollution: 43% of the loss in life expectancy worldwide.

They also found that air pollution had a greater effect on shortening lives in older people, with the exception of deaths in children aged under five in low income countries, such as Africa and South Asia. Globally, about 75% of deaths attributed to air pollution occur in people aged over 60 years.

This is the first study to show the effects of air pollution on deaths according to age, type of disease and also its effect on life expectancy at the level of individual countries and regions.

Professor Jos Lelieveld, who is also from the Cyprus Institute Nicosia, Cyprus, said: "It is remarkable that both the number of deaths and the loss in life expectancy from air pollution rival the effect of tobacco smoking and are much higher than other causes of death. Air pollution exceeds malaria as a global cause of premature death by a factor of 19; it exceeds violence by a factor of 16, HIV/AIDS by a factor of 9, alcohol by a factor of 45, and drug abuse by a factor of 60."

Prof Münzel said: "Since the impact of air pollution on public health overall is much larger than expected, and is a worldwide phenomenon, we believe our results show there is an 'air pollution pandemic'. Policy-makers and the medical community should be paying much more attention to this. Both air pollution and smoking are preventable, but over the past decades much less attention has been paid to air pollution than to smoking, especially among cardiologists.

"In this paper we distinguished between avoidable, human-made air pollution and pollution from natural sources such as desert dust and wildfire emissions, which cannot be avoided. We show that about two-thirds of premature deaths are attributable to human-made air pollution, mainly from fossil fuel use; this goes up to 80% in high-income countries. Five and a half million deaths worldwide a year are potentially avoidable.

"It is important that policy-makers and the medical community realise that air pollution is an important risk factor for heart and blood vessel disease. It should be included as risk factor, along with smoking, diabetes and high blood pressure and cholesterol, in the guidelines of the European Society of Cardiology and the American Heart Association on the prevention of acute and chronic heart syndromes and heart failure."

The researchers estimate that if air pollution was reduced by removing fossil fuel emissions, the average life expectancy worldwide would increase by just over a year, and by nearly two years if all human-made emissions were removed.

However, there are large differences between regions due to the diversity in emissions. In East Asia, which has the highest loss of life expectancy due to avoidable air pollution, three of the average of four years of lost life expectancy could be prevented by the removal of human-made emissions; whereas in Africa, where population growth is rapid and pollution from dust predominates, only 0.7 of 3.1 years lost could be prevented. In Europe, there is an average of 2.2 years of lost life expectancy, 1.7 of which could be prevented, and in North America there is an average of 1.4 years of lost life expectancy, of which 1.1 could be prevented, mostly by phasing out fossil fuels.

Prof Lelieveld said: "In Africa, air pollution represents a health risk that is comparable to HIV/AIDS and malaria. However, in most of the rest of the world air pollution is a much greater health risk. When we looked at how pollution played a role in several diseases, its effect on cardiovascular disease was by far the largest -- very similar to the effect of smoking. Air pollution causes damage to the blood vessels through increased oxidative stress, which then leads to increases in blood pressure, diabetes, stroke, heart attacks and heart failure."

The researchers used exposure data from a model that simulates atmospheric chemical processes and the way they interact with land, sea and chemicals emitted from natural and human-made sources such as energy generation, industry, traffic and agriculture. They applied these to a new model of global exposure and death rates and to data from the Global Burden of Disease, which included information on population density, geographical locations, ages, risk factors for several diseases and causes of death. They estimated the death rates and loss of life expectancy from different causes of air pollution compared to other causes of premature death for countries and regions around the world.

Limitations of the study include the fact there is uncertainty surrounding the estimates, so the size of the effect of air pollution on deaths could be larger or smaller. Nevertheless, such uncertainty also applies to other health risk factors, including smoking. More research is needed to understand fully the mechanisms involved in the associations seen between air pollution and a variety of diseases.

https://www.sciencedaily.com/releases/2020/03/200302200734.htm

COVID-19 infections in U.S. may be much higher, new estimates show

But even moderate interventions can help reduce spread, according to study

March 9, 2020

Science Daily/Cedars-Sinai Medical Center

By March 1, 2020, between 1,043 and 9,484 people in the U.S. may have already been infected by the COVID-19 coronavirus, far more than the number that had been publicly reported, according to a new Cedars-Sinai study.

"This suggests that the opportunity window to contain the epidemic of COVID-19 in its early stage is closing," the researchers stated in their paper, which is posted online on a forum where physicians and researchers share information.

The range of possible patients is significantly higher than the number of confirmed and presumptive U.S. cases reported by the federal Centers for Disease Control and Prevention, which stood at 164 as of March 7. Some news media on March 8 were reporting more than 500 total cases. [Editor's note: as of its March 9 update, the CDC put the total number of COVID-19 cases in the U.S. at 423, including both confirmed and presumptive positive cases.]

Cedars-Sinai investigators, who led the study, said they chose "very conservative" methods to estimate the number of coronavirus cases. "This makes our current estimation likely to be an underestimation of the true number of infected individuals in the U.S.," they wrote.

Shlomo Melmed, MB, ChB, executive vice president of Academic Affairs and dean of the medical faculty at Cedars-Sinai, added: "Cedars-Sinai is committed to the global efforts to combat COVID-19 and we believe that early dissemination of this study and the free sharing of the code that underlies the model will help in those efforts."

To arrive at infection estimates for their new study, the researchers modeled only COVID-19 coronavirus cases "imported" directly to the U.S. from the area of Wuhan, China, before Jan. 23, when the Chinese government locked down the city, and they assumed the lockdown stopped all outbound traffic. Potential cases arriving in the U.S. from other parts of China, or other heavily affected countries such as South Korea, Italy or Iran, were not included in the estimate.

The scale of the COVID-19 epidemic in the U.S. was calculated based on: air traffic data between Wuhan and the U.S., totals of confirmed cases publicly released by the CDC and transmission dynamics as estimated from previous research. The study took into account the identification and quarantine of individual domestic cases in the U.S. Among other considerations, the research team assumed the imported cases were no longer spreading infection.

Based on all these assumptions and methods, the investigators estimated the total number of people in the U.S. infected with coronavirus as of March 1 to be between 1,043 and 9,484. The first figure assumed current preventive procedures -- such as quarantines and screening international travelers at airports -- had reduced as much as 25% of the transmissibility in unidentified cases. The second figure assumed no intervention procedures had been undertaken to reduce the transmissibility.

The disparity between the lowest and highest estimates has important implications for controlling the COVID-19 epidemic, said Dermot P. McGovern, MD, PhD, professor of Medicine and Biomedical Sciences at Cedars-Sinai and senior author of the new study.

"Our model suggests that even moderately effective population interventions to reduce transmission can have a profound impact on the scale of the epidemic," McGovern explained. "This finding supports the role of public health interventions in controlling this disease."

But slowing transmission is not an easy task, given that most COVID-19 cases appear to be mild or even asymptomatic, the researchers noted, which can make it difficult to identify infected individuals who may be spreading the virus.

Despite these obstacles, McGovern said, it may still be possible to mitigate the COVID-19 outbreak through steps already suggested by public health experts.These include promoting social distancing and personal hygiene and restricting large-scale gatherings for occasions such as sporting events.

Additionally, performing mass screening for infected individuals, while expensive and logistically challenging, also would potentially help to control the epidemic, said McGovern, who also is director of Translational Research in the Inflammatory Bowel and Immunobiology Research Institute at Cedars-Sinai.

Dalin Li, PhD, the new study's first author and co-corresponding author with McGovern, said the research team is releasing the just-completed study data online before the full study has been accepted in a journal due to the urgency of the COVID-19 outbreak.

"We are making the results public before peer review as it will be important for timely and informed public health decision-making. We are also making the model available to the research community so that others can build upon it." said Li, a research scientist in the Inflammatory Bowel and Immunobiology Research Institute.

The other co-authors of the study were Jonathan Braun, MD, PhD, professor of Medicine, and research operations associate Gregory Botwin from the Inflammatory Bowel and Immunobiology Research Institute at Cedars-Sinai; and Jun Lv, Weihua Cao and Liming Li, all from Peking University Health Science Center in Beijing.

Funding: Research reported in this publication was supported by the National Institutes of Health, the Helmsley Charitable Trust and the F. Widjaja Foundation.

https://www.sciencedaily.com/releases/2020/03/200309110456.htm

Can't sleep? Prebiotics could help

Dietary compounds found to influence gut metabolites, buffering stress

March 3, 2020

Science Daily/University of Colorado at Boulder

New research shows that animals on a prebiotic diet sleep better and are buffered from the physiological impacts of stress. The undigestible dietary compounds, found in fibrous foods and some dairy products, serve as nourishment for beneficial bacteria and influence metabolites that, in turn, impact the brain.

Specific fibers known as prebiotics can improve sleep and boost stress resilience by influencing gut bacteria and the potent biologically active molecules, or metabolites, they produce, new University of Colorado Boulder research shows.

The research could ultimately lead to new approaches to treating sleep problems, which affect 70 million Americans.

"The biggest takeaway here is that this type of fiber is not just there to bulk up the stool and pass through the digestive system," said Robert Thompson, a postdoctoral researcher in the Department of Integrative Physiology and lead author of the study, published today in the journal Scientific Reports. "It is feeding the bugs that live in our gut and creating a symbiotic relationship with us that has powerful effects on our brain and behavior."

Food for our bugs

Most people are familiar with probiotics, friendly bacteria present in fermented foods like yogurt and sauerkraut. More recently, scientists have taken an interest in prebiotics -- dietary compounds that humans cannot digest but serve as nourishment for our microbiome, or the trillions of bacteria residing within us. While not all fibers are prebiotics, many fibrous foods like leeks, artichokes, onions and certain whole grains are rich in them.

For the study, the researchers started adolescent male rats on either standard chow or chow infused with prebiotics and tracked an array of physiological measures before and after the rats were stressed.

As reported in the researchers' previous study, those on the prebiotic diet spent more time in restorative non-rapid-eye-movement (NREM) sleep. After stress, they also spent more time in rapid-eye-movement (REM) sleep, which is believed to be critical for recovery from stress.

While rats eating standard chow saw an unhealthy flattening of the body's natural temperature fluctuations and a drop in healthy diversity of their gut microbiome after stress, those fed prebiotics were buffered from these effects.

The new study sheds light on how prebiotics can help bust stress.

"We know that this combination of dietary fibers helps promote stress robustness and good sleep and protects the gut microbiome from disruption. With this new study, we wanted to try to identify the signal," said senior author and Integrative Physiology Professor Monika Fleshner, director of the Stress Physiology Laboratory.

Using a technology called mass spectrometry to analyze the rats' fecal samples, the researchers measured metabolites, or bioactive small molecules produced by bacteria as food is broken down.

They found rats on the prebiotic diet had a substantially different "metabolome," or make-up of metabolites. Theirs was higher in dozens of them, including fatty acids, sugars and steroids which may, via gut-brain signaling pathways, influence behavior. The rats' metabolome also looked different after stress.

For instance, the rats on the standard chow diet saw dramatic spikes in allopregnanolone precursor and Ketone Steroid, potentially sleep-disrupting metabolites, while those on the prebiotic diet saw no such spike.

"Our results reveal novel signals that come from gut microbes that may modulate stress physiology and sleep," said Fleshner.

In search of a better sleeping pill

While prebiotic dietary fiber is certainly healthy, it's uncertain whether just loading up on foods rich in it can promote sleep. The rats were fed very high doses of four specific prebiotics, including: galactooligosaccharides, which are present in lentils and cabbage; polydextrose (PDX) an FDA-approved food additive often used as a sweetener; lactoferrin, found in breast milk; and milk fat globular protein, abundant in dairy products.

"You'd probably have to eat a whole lot of lentils and cabbage to see any effect," said Thompson.

Prebiotic supplements already abound on natural food store shelves. But Fleshner said it's too soon to say whether a supplement or drug containing such compounds would be safe and effective for everyone. Depending on what their microbial make-up is, different people might respond differently.

"These are powerful molecules with real neuroactive effects and people need to exercise some caution," she said.

Human studies are already in the works at CU Boulder.

Ultimately, Fleshner believes what they are learning in her lab could lead to a new class of options for people who can't sleep but don't like taking narcotics.

"Armed with this information, we might be able to develop a targeted therapeutic that boosts the molecules that buffer against stress and tamps down the ones that seem to disrupt sleep," she said. "It's exciting to think about."

https://www.sciencedaily.com/releases/2020/03/200303155658.htm

How Does Mental Health Affect Your Sleep?

Contributed By: Rose MacDowell, Sleepopolis

Expert Verified By: Dr. Nicole Moshfegh, Psy.D.

The term mental health describes emotional, cognitive, and social well-being. Mental health is important at every stage of life, from childhood and adolescence through adulthood. Mental health affects not just how we feel, but how we think and behave. Our psychological condition determines how we handle stress, relate to others, and make choices.

There are more than 200 types of mental illness, which is defined by the American Psychiatric Association as “a health condition involving changes in emotion, thinking, and behavior.” Mental illness is based in the brain and can have a significant impact on relationships and quality of life.

Note: The content on Sleepopolis is meant to be informative in nature, but it shouldn’t take the place of medical advice and supervision from a trained professional. If you feel you may be suffering from any sleep disorder or medical condition, please see your healthcare provider immediately.

Mental Illness: Causes and Symptoms

Mental health problems can affect self-esteem, happiness, and basic functions, such as eating and sleeping. (1) Social and financial success is strongly influenced by psychological wellness, including self-awareness and our ability to exercise self-control.

Many factors contribute to mental health issues, including:

• Genes and brain chemistry

• Family history of mental health problems

• Life experiences, such as trauma or abuse

Mental health issues run the gamut from minor difficulty with daily living to full-blown psychosis. Treatment can have a significant impact on the course and outlook of psychological issues, making early detection crucial.

Mental illness can appear in early childhood or not until adulthood. (2) Some psychological issues may not emerge until later in life and can be influenced by certain drugs and medical conditions. There are numerous warning signs of mental health issues. These vary depending on the nature of the condition, and may include:

• Eating or sleeping too much or too little

• Withdrawing from relationships and usual activities

• Having low or no energy

• Feeling numb

• Experiencing unexplained aches and pains

• Feeling helpless or hopeless

FAQ

Q: What is the most common mental illness?A: Depression, a mood disorder that affects 300 million people worldwide, is the single most common mental illness. Anxiety disorders are more prevalent overall. 

Psychological difficulties increase the risk of troubled relationships with family and friends. (3) Interpersonal conflict can be caused by irritability and mood swings, or feelings such as fear and anger. Other cognitive signs associated with mental health issues include worry, confusion, memory loss, and intrusive thoughts.

More serious mental disorders may cause hallucinations, including hearing voices or believing things that are not true. Suicidal behavior or thoughts of harming another person are also common signs of psychological issues. A person suffering from mental illness may experience paranoia, imagined physical ailments, or the need to abuse drugs or alcohol.

Types of Mental Health Disorders

Each type of mood disorder is characterized by unique signs and symptoms and may co-occur with other disorders. For example, anxiety might occur along with substance abuse, physical complaints, or a sleep disorder like insomnia.

The following are some of the most common mental health disorders:

Anxiety Disorders. People with anxiety disorders respond to certain objects or situations with fear and dread. Anxiety disorders can include panic disorders, generalized anxiety disorder, and phobias. (4) Symptoms of anxiety include:

• Fatigue

• Feelings of restlessness or irritability

• Difficulty focusing or learning new concepts

• Chronic pain or muscle tension

• Trouble controlling feelings of worry

• Problems sleeping, including the inability to sleep, unsatisfying sleep, or excessive sleeping

Psychiatric Disorders in Children. Common psychiatric disorders in children include attention deficit hyperactivity disorder (ADHD) a neurodevelopmental disorder that usually persists into adulthood. Symptoms include impulsiveness, trouble focusing on tasks or conversations, restlessness, and feeling easily frustrated. Oppositional defiant disorder is part of a spectrum known as disruptive, impulse-control, and conduct disorders. Symptoms of oppositional defiant disorder include hostility toward and lack of cooperation with teachers, parents, and other authority figures. (5)

Eating Disorders. Eating disorders involve extreme emotions, attitudes, and behaviors related to weight and food. Common eating disorders include anorexia, bulimia, and binge eating.

Substance Use Disorders. Mental health problems and substance abuse disorders often occur together. (6) Substance abuse can be a cause or a result of psychiatric issues, and may be an attempt by some patients to self-medicate or reduce symptoms.

Mood Disorders. Almost one in ten people aged eighteen or older have a mood disorder. Mood disorders involve persistent feelings of sadness, or feelings that fluctuate between extreme happiness and extreme sadness. Mood disorders include:

• Depression. Approximately 17.3 million people in the US — 7.1% of adults — suffered from one or more major depressive episodes in the last year. Depression is characterized by sadness and lack of usual enjoyment that continue for two weeks or longer. Grief and sadness related to a change in life circumstances are different from depression, which doesn’t improve in response to external events

• Bipolar disorder. Bipolar disorder affects approximately six million adults in the US, and impacts men and women equally. The disorder is characterized by severe fluctuations in mood, behavior, and thought patterns. Fluctuations can last from a few hours to several months, and may be affected seasonal and light changes

Personality Disorders. People with personality disorders have inflexible personality traits that are distressing to the sufferer and may cause problems in work, school, or social relationships. (7) These disorders are highly resistant to treatment, and include the following:

• Antisocial personality disorder, or APD. People with antisocial personality disorder exploit, manipulate, and disregard the feelings of others. APD describes the behavior of sociopaths and psychopaths. Psychopaths do not have a conscience, whereas sociopaths have a conscience that is severely disordered

• Narcissistic personality disorder, or NPD. Approximately 1% of people are afflicted with NPD. The disorder is associated with lack of empathy, feelings of superiority, and a need for admiration. Narcissists tend to be easily hurt and are unable to tolerate criticism. Treatment is generally ineffective because people with NPD don’t believe they have a mental health issue

• Borderline personality disorder, or BPD. People with borderline personality disorder have trouble regulating their emotions. They tend to act impulsively, resulting in career and relationship difficulties. Of the 1.4% of the population with BPD, 75% are women, though this number may represent misdiagnosis in many men with the disorder

Psychotic Disorders. Psychotic disorders are characterized by abnormal perceptions such as hallucinations and delusions. Hallucinations are false perceptions that involve hearing or seeing things that don’t exist. Delusions are false beliefs, such as being pursued by authorities or people wishing to do the sufferer harm. The most common psychotic disorder is schizophrenia, which typically appears in the mid to late twenties. Possible causes of schizophrenia include genetic and environmental factors, disordered brain circuitry, trauma, and drug abuse.

Psychosis

Psychosis describes mental conditions that involve loss of contact with reality.

Mental Health and Sleep

One common sign of mental health difficulty is trouble sleeping. (8) The sleep disorder most closely associated with psychiatric disturbances is chronic insomnia. Some common mental illnesses and their effect on sleep include the following:

Depression. Clinical depression often presents with persistent insomnia, or the inability to sleep. (9) Hypersomnia, or excessive drowsiness, can be a sign of depression, as well. Sleep disorders are associated so strongly with depression that some medical practitioners advise caution in diagnosing depression in patients without symptoms of a sleep disorder. Up to 75% of people diagnosed with depression also suffer from insomnia.

Bipolar Disorder. Bipolar disorder is strongly associated with the inability to fall asleep, stay asleep, fall back to sleep, or all three. People in the manic phase of bipolar disorder often have difficulty sleeping, whereas those in the depressive phase may sleep much more than usual. Studies show that sleep deprivation can aggravate the struggles with emotional regulation that are common in people who are bipolar. (10) For many sufferers, trouble sleeping can be an indication of an approaching manic phase.

Anxiety Disorder. Anxiety is a principal cause of chronic insomnia. Even common anxiety related to work and life circumstances may trigger insomnia. A primary cause of chronic insomnia is conditioned anxiety related to sleep and the bedtime routine. Anxiety’s impact on the body includes hyperactivity of the central nervous system and excessive release of stress hormones, such as adrenaline and cortisol. Studies show a strong association between a history of insomnia and anxiety disorder, panic disorder, and social anxiety disorder. (11)

Borderline Personality Disorder. BPD sufferers with insomnia typically experience the daytime consequences of sleep loss, including sleepiness, difficulty concentrating, and irritability. Symptoms of BPD can be worsened by insomnia, leading to a vicious cycle of sleeplessness and behavioral issues.

Personality Disorders. Some personality disorders may be associated with disturbed sleep patterns. (12) One study revealed that people with circadian rhythm disorder are more likely to have a personality disorder than people with normal sleep and wake cycles.

Psychotic Disorders. Psychotic disorders such as schizophrenia can have a profound impact on sleep. Sleep disturbances are often an early sign of schizophrenia and can precede psychiatric symptoms by months or years. Schizophrenia patients are more likely to suffer from other sleep disorders, as well, including:

• Obstructive sleep apnea

• Restless legs syndrome

• Periodic limb movement disorder

• Circadian rhythm dysfunction

FAQ

Q: What is circadian rhythm dysfunction?A: Circadian rhythm dysfunction is caused by a loss of synchronization between sleep-wake cycles and natural light and darkness signals. Symptoms include the inability to fall or stay asleep, cognitive dysfunction, and trouble maintaining a traditional sleep schedule.

Does Depression Cause Insomnia, or Vice Versa?

It was once thought that insomnia symptoms resulted from psychiatric disorders and depression, not the other way around. Now the evidence isn’t so clear. Sleep problems may not just be the result of emotional disturbances, they may increase the likelihood of suffering from them, as well.

Medications to treat psychiatric disturbances may also cause insomnia. Psychotropic medications can have stimulating effects that contribute to interrupted sleep. Restless leg syndrome and periodic limb movements may be triggered or exacerbated by antidepressants and other drugs used to treat mood disorders.

An analysis of major studies revealed that volunteers who suffered from insomnia symptoms were twice as likely to be diagnosed with depression as those without sleep difficulties. Why? Though the connection between mood disorders and insomnia isn’t entirely understood, it is well-known that hormones and neurotransmitters are affected by poor sleep. Sleep is a restorative activity that reduces stress in the body and areas of the brain, especially the axis between the hypothalamus and adrenal and pituitary glands. Excess secretion of cortisol — also known as “the stress hormone” — may play a role, as well.

Lack of sleep and the resulting physiological stress may predispose insomnia sufferers to major mood disturbances, making early treatment of sleep disorders essential, especially in people with a family history of mental health issues. (13)

Depression and Other Sleep Disorders

Insomnia is not the only sleep disorder associated with depression and anxiety. (14) Sleep apnea is a common cause of depression, as is hypersomnia. Sleep apnea is characterized by blockage of the airway and repeated awakenings during the night. Chronic sleep apnea can result in weight gain, increased risk of heart attack and stroke, and memory problems.

Hypersomnia is associated with excessive time spent sleeping and daytime sleepiness. The disorder can be caused by medical conditions, certain drugs, and immune system dysfunction. Though most people need between seven and nine hours of sleep each night, the need for significantly more can indicate a mood disorder. Like sleep apnea, hypersomnia is related to a greater likelihood of heart attack and stroke.

Hypersomnia

A sleep disorder associated with excessive sleeping. Hypersomnia includes narcolepsy, an autoimmune disease that can cause extreme sleepiness and muscle weakness.

Psychiatric Medications and Sleep

Medications to treat psychological disturbances can have a positive or negative impact on sleep. (15) Most antidepressant medications influence the neurotransmitters dopamine, serotonin, and norepinephrine, all of which help to regulate sleep and wake cycles. Some can have stimulating effects that contribute to insomnia.

Restless legs syndrome and periodic limb movements can be triggered or exacerbated by antidepressants and other drugs used to treat mood disorders. (16) These medications can be helpful in patients without movement-related sleep disorders who suffer from hypersomnia.

Other medications such as older tricyclic drugs can help establish healthy sleep patterns in depressed patients with insomnia. Once a depressed patient starts taking medication, insomnia may be the last symptom to improve. Newer antidepressants such as selective serotonin reuptake inhibitors can suppress the REM stage of sleep, as well as the vivid dreaming that occurs during REM sleep.

Antipsychotic medications can help with insomnia, a common issue for schizophrenia sufferers. Some of these drugs can also cause daytime sleepiness, which may be preferable to insomnia. (17) Hypnotic medications are often prescribed along with antipsychotics, and may initially help with insomnia due to their sedative effects. However, many patients become tolerant of hypnotics or develop a rebound response, which can limit their usefulness for insomnia over the long-term.

Suicidal Behavior and Sleep

Suicidal behavior is a common feature of certain psychiatric conditions, including bipolar disorder and depression. Suicidal thoughts and actions can also occur in the absence of a psychiatric condition. Suicide is the second leading cause of death in people between 15 and 24. Suicide is more likely to be completed by people with access to guns.

Signs of suicidal thoughts and behavior may include the following:

• Speaking about suicide or the desire to die

• Feeling or talking about feeling hopeless

• Researching ways to commit suicide

• Appearing anxious or depressed

• Excessive use of alcohol, or use of drugs

• Exhibiting unusual behavior, such as rage, mood swings, or agitation

Suicidal behavior is often caused by psychiatric conditions, but may also be triggered by difficult life events, stress, loss of a loved one, or past trauma such as emotional, physical, or sexual abuse. Suicidal behavior is also more common in people suffering from post-traumatic stress disorder or chronic pain.

Recent research reveals that suicidal behavior and lack of sufficient sleep are related in adolescents and adults. (18) People who completed their suicidal actions were more likely to have suffered from insomnia, hypersomnia, or another sleep disturbance. Though further research is needed to better understand this link, existing studies reveal a strong association between mental health and sleep.

FAQ

Q: What is suicidal ideation?A: Suicidal ideation involves thinking about, planning, or considering suicide.

Last Word From Sleepopolis

Mental health is critically important to happiness and well-being. Research reveals a connection between mental illness and disturbed sleep, an association that may exist months or years before psychiatric symptoms appear.

Medications and other mental health treatments can help regulate sleep patterns, but may also cause or worsen insomnia, hypersomnia, and other sleep difficulties. Adjustment of medications or separate treatment of sleep issues can help establish healthy sleep patterns and improve quality of life for people suffering from mental health disorders.

References

1. Amy C. Watson, Self-Stigma in People With Mental Illness, Schizophrenia Bulletin, January 25, 2007

2. William Copeland Ph.D., Cumulative Prevalence of Psychiatric Disorders by Young Adulthood: A Prospective Cohort Analysis From the Great Smoky Mountains Study, Journal of the American Academy of Child & Adolescent Psychiatry, March 2011

3. Alan R. Teo, Social Relationships and Depression: Ten-Year Follow-Up from a Nationally Representative Study, Plos One, April 30, 2013

4. Peter J. Norton, Transdiagnostic models of anxiety disorder: Theoretical and empirical underpinnings, Clinical Psychology Review, August 2017

5. Martin B. Keller, MD, The Disruptive Behavioral Disorder in Children and Adolescents: Comorbidity and Clinical Course, Journal of the American Academy of Child & Adolescent Psychiatry, March 1992

6. Robert E Drake, et al. A systematic review of psychosocial research on psychosocial interventions for people with co-occurring severe mental and substance use disorders, Journal of Substance Abuse Treatment, January 2008

7. Tyrer P, Mulder R, Crawford M, Newton-Howes G, Simonsen E, Ndetei D, Koldobsky N, Fossati A, Mbatia J, Barrett B., Personality disorder: a new global perspective, World Psychiatry, February 2010

8. Krahn LE., Psychiatric disorders associated with disturbed sleep, Seminars in Neurology, March 25, 2005

9. Chiara Baglioni et al., Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies, Journal of Affective Disorders, December 2011

10. Harvey AG, Talbot LS, Gershon A, Sleep Disturbance in Bipolar Disorder Across the Lifespan, Clinical Psychology, New York State Psychiatric Institute, April 8, 2012

11. Heidemarie Blumenthal, et al., The Links Between Social Anxiety Disorder, Insomnia Symptoms, and Alcohol Use Disorders: Findings From a Large Sample of Adolescents in the United States, Behavior Therapy, January 2019

12. Yaron Dagan, High prevalence of personality disorders among Circadian Rhythm Sleep Disorders (CRSD) patients, Journal of Psychosomatic Research, October 1996

13. Liu X, Buysse DJ, Gentzler AL, Kiss E, Mayer L, Kapornai K, Vetró A, Kovacs M., Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression, Sleep, January 30, 2007

14. Nutt D, Wilson S, Paterson L., Sleep disorders as core symptoms of depression, Dialogues in Clinical Neuroscience, September 2008

15. DeMartinis NA, Winokur A., Effects of psychiatric medications on sleep and sleep disorders, CNS and Neurological Disorders Drug Targets, February 6, 2007

16. Staner L., Sleep disturbances, psychiatric disorders, and psychotropic drugs, Dialogues in Clincal Neuroscience, December 7, 2005

17. Waite F, Myers E, Harvey AG, Espie CA, Startup H, Sheaves B, Freeman D., Treating Sleep Problems in Patients with Schizophrenia, Behavioural and Cognitive Psychotherapy, May 2016

18. Goldstein TR, Bridge JA, Brent DA., Sleep Disturbance Preceding Completed Suicide in Adolescents, Journal of Consulting and Clinical Psychology, February 17, 2010

Original article: https://sleepopolis.com/education/how-does-mental-health-affect-your-sleep/

• Bio

Rose MacDowell

Rose is the Chief Research Officer at Sleepopolis, which allows her to indulge her twin passions for dense scientific studies and writing about health and wellness. An incurable night owl, she loves discovering the latest information about sleep and how to get (lots) more of it. She is a published novelist who has written everything from an article about cheese factories to clock-in instructions for assembly line workers in Belgium. One of her favorite parts of her job is connecting with the best sleep experts in the industry and utilizing their wealth of knowledge in the pieces she writes. She enjoys creating engaging articles that make a difference in people’s lives. Her writing has been reviewed by The Boston Globe, Cosmopolitan, and the Associated Press, and received a starred review in Publishers Weekly. When she isn’t musing about sleep, she’s usually at the gym, eating extremely spicy food, or wishing she were snowboarding in her native Colorado. Active though she is, she considers staying in bed until noon on Sundays to be important research.

Let there be 'circadian' light

New study describes science behind best lights to affect sleep, mood and learning

February 20, 2020

Science Daily/University of Washington Health Sciences/UW Medicine

Researchers said the wavelengths at sunrise and sunset have the biggest impact to brain centers that regulate our circadian clock and our mood and alertness.

Their study, "A color vision circuit for non-image-forming vision in the primate retina," published in Current Biology Feb. 20, identifies a cell in the retina, which plays an important role in signaling our brain centers that regulate circadian rhythms, boost alertness, help memory and cognitive function, and elevate mood.

These effects have been attributed to a pigment in the eye called melanopsin, which is sensitive to blue light, but researchers say cone photoreceptors are a thousand times more sensitive to light than melanopsin. The cone photoreceptor inputs to the circadian circuity respond to short wavelength blue light, but they also respond strongly to long wavelength oranges and yellows and contrasting light -- the colors at sunrise and sunset. What makes good lighting, researchers discovered, is lighting capable of stimulating the cone photoreceptor inputs to specific neurons in the eye that regulate circadian rhythms.

Lead author Sara Patterson, a graduate student in neuroscience at the University of Washington School of Medicine, said how we set our internal clocks to the external light-dark cycle has been studied a lot. But how the changes in the color of light affect our brain has not.

"Color vision used for something other than color perception was the most exciting part for me," she said.

In the study, Patterson and colleagues identified a cell known as an inhibitory interneuron or amacrine cell in the retina, which signals to photosensitive ganglion cells that affect our circadian brain centers. The researchers said these amacrine cells provide "the missing component of an evolutionary ancient color vision circuit capable of setting the circadian clock by encoding the spectral content of light."

Patterson said so little is known about rare retinal circuitry that it was possible to find a new blue cone cell. She said there is a lot more to be discovered about how blue cone cells are projecting to other areas of the brain.

While sunrise lights, blue lights and seasonal affective disorder (SAD) lights have all tried to capture benefits of natural light, they haven't been that effective because they are missing key science data, said corresponding author Jay Neitz, professor of ophthalmology at the UW School of Medicine, a scientist at the UW Medicine Eye Institute, and a well-known color vision researcher. He said the science behind SAD lights, for example, is to make lights hundreds of times brighter than normal lights to stimulate melanopsin.

"This research all started because of our interest in the health benefits of having natural light that occurs at the right time of day that helps regulate our circadian clock and our mood and alertness," Neitz said.

The University of Washington has licensed technology based on this discovery to TUO (https://www.thetuolife.com/), a lighting technology company that will be selling white LED lightbulbs that will incorporate undetectable sunrise and sunset wavelengths for commercial use.

The work was supported by the National Eye Institute and Research to Prevent Blindness. Other collaborators include James A. Kuchenbecker, research scientist/biomedical engineer with the Department of Ophthalmology at the University of Washington School of Medicine; James R. Anderson, research scientist/software architect with the John A. Moran Eye Center at the University of Utah School of Medicine, and Maureen Neitz, professor of ophthalmology at the University of Washington School of Medicine.

https://www.sciencedaily.com/releases/2020/02/200220141731.htm

Air pollution's tiny particles may trigger nonfatal heart attacks

February 14, 2020

Science Daily/Yale School of Public Health

Yale-affiliated scientist finds that even a few hours' exposure to ambient ultrafine particles common in air pollution may potentially trigger a nonfatal heart attack.

Myocardial infarction is a major form of cardiovascular disease worldwide. Ultrafine particles (UFP) are 100 nanometers or smaller in size. In urban areas, automobile emissions are the primary source of UFP.

The study in the journal Environmental Health Perspectives is believed to be the first epidemiological investigation of the effects of UFP exposure and heart attacks using the number of particles and the particle length and surface area concentrations at hourly intervals of exposure.

"This study confirms something that has long been suspected -- air pollution's tiny particles can play a role in serious heart disease. This is particularly true within the first few hours of exposure," said Kai Chen, Ph.D., assistant professor at Yale School of Public Health and the study's first author. "Elevated levels of UFP are a serious public health concern."

UFP constitute a health risk due to their small size, large surface areas per unit of mass, and their ability to penetrate the cells and get into the blood system. "We were the first to demonstrate the effects of UFP on the health of asthmatics in an epidemiological study in the 1990s," said Annette Peters, director of the Institute of Epidemiology at Helmholtz Center Munich and a co-author of this paper. "Since then approximately 200 additional studies have been published. However, epidemiological evidence remains inconsistent and insufficient to infer a causal relationship."

The lack of consistent findings across epidemiological studies may be in part because of the different size ranges and exposure metrics examined to characterize ambient UFP exposure. Chen and his co-authors were interested in whether transient UFP exposure could trigger heart attacks and whether alternative metrics such as particle length and surface area concentrations could improve the investigation of UFP-related health effects.

With colleagues from Helmholtz Center Munich, Augsburg University Hospital and Nördlingen Hospital, Chen examined data from a registry of all nonfatal MI cases in Augsburg, Germany. The study looked at more than 5, 898 nonfatal heart attack patients between 2005 and 2015. The individual heart attacks were compared against air pollution UFP data on the hour of the heart attack and adjusted for a range of additional factors, such as the day of the week, long-term time trend and socioeconomic status.

"This represents an important step toward understanding the appropriate indicator of ultrafine particles exposure in determining the short-term health effects, as the effects of particle length and surface concentrations were stronger than the ones of particle number concentration and remained similar after adjustment for other air pollutants," said Chen. "Our future analyses will examine the combined hourly exposures to both air pollution and extreme temperature. We will also identify vulnerable subpopulations regarding pre-existing diseases and medication intake."

https://www.sciencedaily.com/releases/2020/02/200214134717.htm

Reconnecting with nature key for the health of people and the planet

February 13, 2020

Science Daily/University of Plymouth

Researchers are the first to investigate -- within a single study -- the contribution of both nature contact and connection to human health, well-being and pro-environmental behaviors.

Individuals who visit natural spaces weekly, and feel psychologically connected to them, report better physical and mental wellbeing, new research has shown.

Alongside the benefits to public health, those who make weekly nature visits, or feel connected to nature, are also more likely to behave in ways which promote environmental health, such as recycling and conservation activities.

The findings of the study, published in the Journal of Environmental Psychology, indicate that reconnecting with nature could be key to achieving synergistic improvements to human and planetary health.

The study was conducted by researchers at the University of Plymouth, Natural England, the University of Exeter and University of Derby, and is the first to investigate -- within a single study -- the contribution of both nature contact and connection to human health, wellbeing and pro-environmental behaviours.

The findings are based on responses to the Monitor of Engagement with the Natural Environment (MENE) survey, commissioned by Natural England as part of DEFRA's social science research programme. The team looked at people's engagement with nature though access to greenspace, nature visits and the extent to which they felt psychologically connected to the natural world.

Lead author Leanne Martin, of the University of Plymouth, said: "In the context of increasing urbanisation, it is important to understand how engagement with our planet's natural resources relate to human health and behaviour. Our results suggest that physically and psychologically reconnecting with nature can be beneficial for human health and wellbeing, and at the same time encourages individuals to act in ways which protect the health of the planet."

Marian Spain, Chief Executive of Natural England added: "It's a top priority for Natural England to unlock the potential of the natural environment to help address the challenges we are facing as a society: poor physical health and mental wellbeing; the climate change crisis and the devastating loss of wildlife.

"These findings give vital new insights of the need to not just increase contact with nature, but about the sorts of experience that really help people build an emotional connection, which is key to unlocking health benefits as well as inspiring people to taking action to help their environment. We look forward to using the research as we work with our many partners to support more people from all walks of life to benefit from thriving nature."

https://www.sciencedaily.com/releases/2020/02/200213090912.htm

Sound of music: How melodic alarms could reduce morning grogginess

The sounds that wake you up could be affecting how groggy and clumsy you are in the morning

February 3, 2020

Science Daily/RMIT University

New research suggests melodic alarms could improve alertness, with harsh alarm tones linked to increased levels of morning grogginess.

Beep beep beep or Beach Boys? The sounds you wake up to could be affecting how groggy and clumsy you are in the morning, according to new research.

A study by RMIT University suggests melodic alarms could improve alertness levels, with harsh alarm tones linked to increased levels of morning grogginess.

The surprising finding, published in PLoS One, could have important implications for anyone who needs to perform at their peak soon after waking, such as shift workers and emergency first responders.

Lead author, RMIT doctoral researcher Stuart McFarlane, said morning grogginess -- or sleep inertia -- was a serious problem in our 24-hour world.

"If you don't wake properly, your work performance can be degraded for periods up to four hours, and that has been linked to major accidents," McFarlane said.

"You would assume that a startling 'beep beep beep' alarm would improve alertness, but our data revealed that melodic alarms may be the key element. This was unexpected.

"Although more research is needed to better understand the precise combination of melody and rhythm that might work best, considering that most people use alarms to wake up, the sound you choose may have important ramifications.

"This is particularly important for people who might work in dangerous situations shortly after waking, like firefighters or pilots, but also for anyone who has to be rapidly alert, such as someone driving to hospital in an emergency."

The research involved 50 participants, using a specially designed online survey that enable them to remotely contribute to the study from the comfort of their own home.

Each person logged what type of sound they used to wake up, and then rated their grogginess and alertness levels against standardised sleep inertia criteria.

Co-author Associate Professor Adrian Dyer, from RMIT's School of Media and Communication and Digital Ethnography Research Centre, said the research could help contribute to the design of more efficient interventions for people to use on their own devices to wake up properly.

"This study is important, as even NASA astronauts report that sleep inertia affects their performance on the International Space Station," Dyer said.

"We think that a harsh 'beep beep beep' might work to disrupt or confuse our brain activity when waking, while a more melodic sound like the Beach Boys 'Good Vibrations' or The Cure's 'Close to Me' may help us transition to a waking state in a more effective way.

"If we can continue to improve our understanding of the connection between sounds and waking state, there could be potential for applications in many fields, particularly with recent advancements in sleep technology and artificial intelligence."

https://www.sciencedaily.com/releases/2020/02/200203104505.htm

Could resetting our internal clocks help control diabetes?

January 31, 2020

Science Daily/Université de Genève

The circadian clock system allows the organisms to adjust to periodical changes of geophysical time. Today, increasing evidence show that disturbances in our internal clocks stemming from frequent time zone changes, irregular working schedules or ageing, have a significant impact on the development of metabolic diseases including type-2 diabetes. Using a molecule extracted from lemon peel, researchers have succeeded in 'repairing' the disrupted cellular clocks.

The circadian clock system (from Latin "circa diem," about a day) allows the organisms to anticipate periodical changes of geophysical time, and to adjust to these changes. Nearly all the cells in our body comprise molecular clocks that regulate and synchronize metabolic functions to a 24-hour cycle of day-night changes. Today, increasing evidence show that disturbances in our internal clocks stemming from frequent time zone changes, irregular working schedules or ageing, have a significant impact on the development of metabolic diseases in human beings, including type-2 diabetes. Such disturbances seem to prevent the proper functioning of the cells in the pancreatic islet that secrete insulin and glucagon, the hormones that regulate blood sugar levels. By comparing the pancreatic cells of type 2 diabetic human donors with those of healthy people, researchers at the University of Geneva (UNIGE) and at the University Hospitals of Geneva (HUG), Switzerland, were able to demonstrate, for the first time, that the pancreatic islet cells derived from the Type 2 Diabetic human donors bear compromised circadian oscillators. The disruption of the circadian clocks was concomitant with the perturbation of hormone secretion. Moreover, using clock modulator molecule dubbed Nobiletin, extracted from lemon peel, the researchers succeeded in "repairing" the disrupted cellular clocks and in partial restoring of the islet cell function. These results, published in the Proceedings of the National Academy of Sciences of the United States, provide a first insight into innovative approach for diabetes care.

Two years ago, the team led by Charna Dibner, Principle Investigator in the Departments of Medicine and of Cell Physiology and Metabolism, and Diabetes Centre at UNIGE Faculty of Medicine, and at HUG, has already shown that in rodents the perturbation of pancreatic cellular clocks led to disrupted insulin and glucagon secretion, thus promoting the onset of diabetes. But what is the situation in human beings? "We had also previously observed that if the clocks of human pancreatic cells were artificially disrupted in the cellular culture in vitro, secretion of the key islet hormones -- insulin and glucagon -- was compromised," says Volodymyr Petrenko, a researcher in Dr. Dibner's lab and the first author of these publications. Hence our next step, that we report here, was to unravel whether the circadian rhythms were perturbed in human pancreatic islets in type 2 diabetes, and, if so, how would this perturbation affect the islet function."

Using combined bioluminescence-fluorescence time-lapse microscopy, a technology that allows tracking the molecular clock activity in living cells very precisely over time, the scientists compared the behaviour of pancreatic cell of type-2 diabetic donors and those of healthy subjects throughout the day. "The verdict is indisputable," says Charna Dibner. The biological rhythms of the islet cells in type-2 diabetes exhibit both reduced amplitudes of circadian oscillations and poor synchronization capacity. "As a result, hormone secretion is no longer coordinated. Moreover, the defects in temporal coordination of insulin and glucagon secretion observed in patients with type-2 diabetes were comparable to those measured in healthy islet cells with artificially-disrupted circadian clock."

It's all in the timing!

Circadian clocks represent the daily cycles governing the various cellular functions. There are several interlocking levels of synchronization of these clocks, the main one being light, which in particular regulates the central clock located in the cerebral hypothalamus. Like a conductor in the orchestra, it regulates peripheral clocks present in organs and cells. The latter are therefore partly centrally regulated, but function differently in each organ, and even in each cell, depending on their functions. "Pancreatic cells are also subject to the rhythm of fasting and food intake, and to a tight hormonal regulation," says Charna Dibner. "Coordinating all levels of regulation therefore allows the optimization of metabolic functions. Clocks deregulation in pancreatic islet leads to a compromised function: they are not anymore anticipating food-derived signals. Indeed, if you eat the same food but at night rather than during the day, you may gain weight much faster, due to a suboptimal response of your metabolism."

Setting the right time again

Step two of their research: the Geneva scientists used Nobiletin, a small clock modulator molecule -- a natural ingredient of lemon peel whose impact on circadian clocks has been recently discovered -- in order to resynchronize the clocks. "By acting on one of the core-clock components, it resets efficiently the amplitude of the oscillations in the human islets" says Volodymyr Petrenko. "And as soon as we got the clocks back in sync, we also observed an improvement in insulin secretion."

"This is the first proof of principle that repairing compromised circadian clocks may help improving the function of the pancreatic islet hormone secretion," says Charna Dibner. "We will continue by exploring this repair mechanism in vivo, first in animal models. Our society experiences epidemic growth in metabolic diseases, concomitant with shifted working and eating schedules, and lack of sleep. By re-synchronizing the perturbed molecular clocks, either by personalized eating and exercise schedules or with the help of clock modulator molecules, we hope to ultimately be able to provide an innovative solution to an epidemical metabolic problem affecting an ever-increasing proportion of the world's population."

https://www.sciencedaily.com/releases/2020/01/200131074205.htm