Air pollution's connection to infant mortality
June 29, 2020
Science Daily/Stanford University
The study of sub-Saharan Africa finds that a relatively small increase in airborne particles significantly increase infant mortality rates. A cost-effective solution may lie in an exotic-sounding proposal.
Dust sweeping across the Southeast U.S. in recent days warns of a growing risk to infants and children in many parts of the world. A Stanford-led study focuses on this dust, which travels thousands of miles from the Sahara Desert, to paint a clearer picture than ever before of air pollution's impact on infant mortality in sub-Saharan Africa. The paper, published June 29 in Nature Sustainability, reveals how a changing climate might intensify or mitigate the problem, and points to seemingly exotic solutions to reducing dust pollution that could be more effective and affordable than current health interventions in improving child health.
"Africa and other developing regions have made remarkable strides overall in improving child health in recent decades, but key negative outcomes such as infant mortality remain stubbornly high in some places," said study senior author Marshall Burke, an associate professor of Earth system science in Stanford's School of Earth, Energy & Environmental Sciences. "We wanted to understand why that was, and whether there was a connection to air pollution, a known cause of poor health."
Understanding airborne danger
Children under 5 are particularly vulnerable to the tiny particles, or particulate, in air pollution that can have a range of negative health impacts, including lower birth weight and impaired growth in the first year of life. In developing regions, exposure to high levels of air pollution during childhood is estimated to reduce overall life expectancy by 4-5 years on average.
Quantifying the health impacts of air pollution -- a crucial step for understanding global health burdens and evaluating policy choices -- has been a challenge in the past. Researchers have struggled to adequately separate out the health effects of air pollution from the health effects of activities that generate the pollution. For example, a booming economy can produce air pollution but also spur developments, such as lower unemployment, that lead to better healthcare access and improved health outcomes.
To isolate the effects of air pollution exposure, the Stanford-led study focuses on dust carried thousands of miles from the Bodélé Depression in Chad -- the largest source of dust emissions in the world. This dust is a frequent presence in West Africa and, to a lesser extent, across other African regions. The researchers analyzed 15 years of household surveys from 30 countries across Sub-Saharan Africa covering nearly 1 million births. Combining birth data with satellite-detected changes in particulate levels driven by the Bodélé dust provided an increasingly clear picture of poor air quality's health impacts on children.
Sobering findings and surprising solutions
The researchers found that a roughly 25 percent increase in local annual mean particulate concentrations in West Africa causes an 18 percent increase in infant mortality. The results expand on a 2018 paper by the same researchers that found exposure to high particulate matter concentrations in sub-Saharan Africa accounted for about 400,000 infant deaths in 2015 alone.
The new study, combined with previous findings from other regions, makes clear that air pollution, even from natural sources, is a "critical determining factor for child health around the world," the researchers write. Emissions from natural sources could change dramatically in a changing climate, but it's unclear how. For example, the concentration of dust particulate matter across Sub-Saharan Africa is highly dependent on the amount of rainfall in the Bodélé Depression. Because future changes in rainfall over the Bodélé region due to climate change are highly uncertain, the researchers calculated a range of possibilities for sub-Saharan Africa that could result in anywhere from a 13-percent decline in infant mortality to a 12-percent increase just due to changes in rainfall over the desert. These impacts would be larger than any other published projections for climate change impact on health across Africa.
Safeguarding children against air pollution is nearly impossible in many developing regions because many homes have open windows or permeable roofs and walls, and infants and young children are unlikely to wear masks. Instead, the researchers suggest exploring the possibility of dampening sand with groundwater in the Bodélé region to stop it from going airborne -- an approach that has been successful at small scale in California.
The researchers estimate that deploying solar-powered irrigation systems in the desert area could avert 37,000 infant deaths per year in West Africa at a cost of $24 per life, making it competitive with many leading health interventions currently in use, including a range of vaccines and water and sanitation projects.
"Standard policy instruments can't be counted on to reduce all forms of air pollution," said study lead author Sam Heft-Neal, a research scholar at Stanford's Center on Food Security and the Environment. "While our calculation doesn't consider logistical constraints to project deployment, it highlights the possibility of a solution that targets natural pollution sources and yields enormous benefits at a modest cost."
https://www.sciencedaily.com/releases/2020/06/200629120215.htm
Living near major roads linked to risk of dementia, Parkinson's, Alzheimer's and MS
January 23, 2020
Science Daily/University of British Columbia
Living near major roads or highways is linked to higher incidence of dementia, Parkinson's disease, Alzheimer's disease and multiple sclerosis (MS), suggests new research published this week in the journal Environmental Health.
Researchers from the University of British Columbia analyzed data for 678,000 adults in Metro Vancouver. They found that living less than 50 metres from a major road or less than 150 metres from a highway is associated with a higher risk of developing dementia, Parkinson's, Alzheimer's and MS -- likely due to increased exposure to air pollution.
The researchers also found that living near green spaces, like parks, has protective effects against developing these neurological disorders.
"For the first time, we have confirmed a link between air pollution and traffic proximity with a higher risk of dementia, Parkinson's, Alzheimer's and MS at the population level," says Weiran Yuchi, the study's lead author and a PhD candidate in the UBC school of population and public health. "The good news is that green spaces appear to have some protective effects in reducing the risk of developing one or more of these disorders. More research is needed, but our findings do suggest that urban planning efforts to increase accessibility to green spaces and to reduce motor vehicle traffic would be beneficial for neurological health."
Neurological disorders -- a term that describes a range of disorders, including Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis and motor neuron diseases -- are increasingly recognized as one of the leading causes of death and disability worldwide. Little is known about the risk factors associated with neurological disorders, the majority of which are incurable and typically worsen over time.
For the study, researchers analyzed data for 678,000 adults between the ages of 45 and 84 who lived in Metro Vancouver from 1994 to 1998 and during a follow-up period from 1999 to 2003. They estimated individual exposures to road proximity, air pollution, noise and greenness at each person's residence using postal code data. During the follow-up period, the researchers identified 13,170 cases of non-Alzheimer's dementia, 4,201 cases of Parkinson's disease, 1,277 cases of Alzheimer's disease and 658 cases of MS.
For non-Alzheimer's dementia and Parkinson's disease specifically, living near major roads or a highway was associated with 14 per cent and seven per cent increased risk of both conditions, respectively. Due to relatively low numbers of Alzheimer's and MS cases in Metro Vancouver compared to non-Alzheimer's dementia and Parkinson's disease, the researchers did not identify associations between air pollution and increased risk of these two disorders. However, they are now analyzing Canada-wide data and are hopeful the larger dataset will provide more information on the effects of air pollution on Alzheimer's disease and MS.
When the researchers accounted for green space, they found the effect of air pollution on the neurological disorders was mitigated. The researchers suggest that this protective effect could be due to several factors.
"For people who are exposed to a higher level of green space, they are more likely to be physically active and may also have more social interactions," said Michael Brauer, the study's senior author and professor in the UBC school of population and public health. "There may even be benefits from just the visual aspects of vegetation."
Brauer added that the findings underscore the importance for city planners to ensure they incorporate greenery and parks when planning and developing residential neighbourhoods.
https://www.sciencedaily.com/releases/2020/01/200123152616.htm
Mix of stress and air pollution may lead to cognitive difficulties in children
January 16, 2020
Science Daily/Columbia University's Mailman School of Public Health
Children with elevated exposure to early life stress in the home and elevated prenatal exposure to air pollution exhibited heightened symptoms of attention and thought problems, according to researchers at Columbia University Mailman School of Public Health and Columbia Psychiatry. Early life stress is common in youth from disadvantaged backgrounds who also often live in areas with greater exposure to air pollution.
Air pollution has negative effects on physical health, and recent work has begun to also show negative effects on mental health. Life stress, particularly early in life, is one of the best-known contributors to mental health problems. The new study is one of the first to examine the combined effects of air pollution and early life stress on school-age children. Results appear in the Journal of Child Psychology and Psychiatry.
"Prenatal exposure to polycyclic aromatic hydrocarbons, a neurotoxicant common in air pollution, seems to magnify or sustain the effects of early life social and economic stress on mental health in children," says first author David Pagliaccio, PhD, assistant professor of clinical neurobiology in psychiatry at Columbia Psychiatry.
"Air pollutants are common in our environment, particularly in cities, and given socioeconomic inequities and environmental injustice, children growing up in disadvantaged circumstances are more likely to experience both life stress and exposure to neurotoxic chemicals," says senior author Amy Margolis, PhD, assistant professor of medical psychology in psychiatry at Columbia Psychiatry.
"These exposures have a combined effect on poor mental health outcomes and point to the importance of public health programs that try to lessen exposure to these critical risk factors, to improve not only physical, but psychological health," says Julie Herbstman, PhD, associate professor of environmental health science and director of the Columbia Center for Children's Environmental Health at Columbia Mailman School of Public Health.
Data were from the CCCEH Mothers and Newborns longitudinal birth cohort study in Northern Manhattan and the Bronx, which includes many participants who self-identify as African American or Dominican. Mothers wore an air monitoring backpack during the third trimester of pregnancy to measure exposure to air pollutants in their daily lives. When their children were 5 years old, mothers reported on stress in their lives, including neighborhood quality, material hardship, intimate partner violence, perceived stress, lack of social support, and general distress levels. Mothers then reported on their child's psychiatric symptoms at ages 5, 7, 9 and 11.
The combined effect of air pollution and early life stress was seen across several measures of thought and attention problems/ADHD at age 11. (Thought problems included obsessive thoughts and behaviors or thoughts that others find strange.) The effects were also linked to PAH-DNA adducts -- a dose-sensitive marker of air pollution exposure.
The researchers say PAH and early life stress may serve as a "double hit" on shared biological pathways connected to attention and thought problems. Stress likely leads to wide-ranging changes in, for example, epigenetic expression, cortisol, inflammation, and brain structure and function. The mechanism underlying the effects of PAH is still being interrogated; however, alterations in brain structure and function represent possible shared mechanistic pathways.
Earlier studies making use of the same longitudinal cohort data found that prenatal exposure to air pollution combines with material hardship to significantly increase ADHD symptoms in children. A separate study found a combination of air pollution and poverty lowered child IQ.
https://www.sciencedaily.com/releases/2020/01/200116155436.htm
Air pollution's tiny particles may trigger nonfatal heart attacks
February 14, 2020
Science Daily/Yale School of Public Health
Yale-affiliated scientist finds that even a few hours' exposure to ambient ultrafine particles common in air pollution may potentially trigger a nonfatal heart attack.
Myocardial infarction is a major form of cardiovascular disease worldwide. Ultrafine particles (UFP) are 100 nanometers or smaller in size. In urban areas, automobile emissions are the primary source of UFP.
The study in the journal Environmental Health Perspectives is believed to be the first epidemiological investigation of the effects of UFP exposure and heart attacks using the number of particles and the particle length and surface area concentrations at hourly intervals of exposure.
"This study confirms something that has long been suspected -- air pollution's tiny particles can play a role in serious heart disease. This is particularly true within the first few hours of exposure," said Kai Chen, Ph.D., assistant professor at Yale School of Public Health and the study's first author. "Elevated levels of UFP are a serious public health concern."
UFP constitute a health risk due to their small size, large surface areas per unit of mass, and their ability to penetrate the cells and get into the blood system. "We were the first to demonstrate the effects of UFP on the health of asthmatics in an epidemiological study in the 1990s," said Annette Peters, director of the Institute of Epidemiology at Helmholtz Center Munich and a co-author of this paper. "Since then approximately 200 additional studies have been published. However, epidemiological evidence remains inconsistent and insufficient to infer a causal relationship."
The lack of consistent findings across epidemiological studies may be in part because of the different size ranges and exposure metrics examined to characterize ambient UFP exposure. Chen and his co-authors were interested in whether transient UFP exposure could trigger heart attacks and whether alternative metrics such as particle length and surface area concentrations could improve the investigation of UFP-related health effects.
With colleagues from Helmholtz Center Munich, Augsburg University Hospital and Nördlingen Hospital, Chen examined data from a registry of all nonfatal MI cases in Augsburg, Germany. The study looked at more than 5, 898 nonfatal heart attack patients between 2005 and 2015. The individual heart attacks were compared against air pollution UFP data on the hour of the heart attack and adjusted for a range of additional factors, such as the day of the week, long-term time trend and socioeconomic status.
"This represents an important step toward understanding the appropriate indicator of ultrafine particles exposure in determining the short-term health effects, as the effects of particle length and surface concentrations were stronger than the ones of particle number concentration and remained similar after adjustment for other air pollutants," said Chen. "Our future analyses will examine the combined hourly exposures to both air pollution and extreme temperature. We will also identify vulnerable subpopulations regarding pre-existing diseases and medication intake."
https://www.sciencedaily.com/releases/2020/02/200214134717.htm
Studies link air pollution to mental health issues in children
September 25, 2019
Science Daily/Cincinnati Children's Hospital Medical Center
Three new studies by scientists at Cincinnati Children's Hospital Medical Center, in collaboration with researchers at the University of Cincinnati, highlight the relationship between air pollution and mental health in children.
A study to be published Sept. 25 in Environmental Health Perspectives found that short-term exposure to ambient air pollution was associated with exacerbations of psychiatric disorders in children one to two days later, as marked by increased utilization of the Cincinnati Children's emergency department for psychiatric issues. The study also found that children living in disadvantaged neighborhoods may be more susceptible to the effects of air pollution compared to other children, especially for disorders related to anxiety and suicidality.
The lead authors of this study are Cole Brokamp, PhD, and Patrick Ryan, PhD. They are researchers in the division of Biostatistics and Epidemiology at Cincinnati Children's.
"This study is the first to show an association between daily outdoor air pollution levels and increased symptoms of psychiatric disorders, like anxiety and suicidality, in children," says Dr. Brokamp. "More research is needed to confirm these findings, but it could lead to new prevention strategies for children experiencing symptoms related to a psychiatric disorder. The fact that children living in high poverty neighborhoods experienced greater health effects of air pollution could mean that pollutant and neighborhood stressors can have synergistic effects on psychiatric symptom severity and frequency."
Two other Cincinnati Children's studies were recently published that also link air pollution to children's mental health:
· A study published in Environmental Research found an association between recent high traffic related air pollution (TRAP) exposure and higher generalized anxiety. The study is believed to be the first to use neuroimaging to link TRAP exposure, metabolic disturbances in the brain, and generalized anxiety symptoms among otherwise healthy children. The study found higher myoinositol concentrations in the brain -- a marker of the brain's neuroinflammatory response to TRAP.
· The lead authors of this study are Kelly Brunst, PhD, a researcher in the department of Environmental Health at the University of Cincinnati, and Kim Cecil, PhD, a researcher at Cincinnati Children's.
· A study published in Environmental Research found that exposure to TRAP during early life and across childhood was significantly associated with self-reported depression and anxiety symptoms in 12 year olds. Similar findings have been reported in adults, but research showing clear connections between TRAP exposure and mental health in children has been limited.
The lead authors of the study are Kimberly Yolton, PhD, director of research in the division of General and Community Pediatrics at Cincinnati Children's, and Dr. Ryan.
"Collectively, these studies contribute to the growing body of evidence that exposure to air pollution during early life and childhood may contribute to depression, anxiety, and other mental health problems in adolescence," says Dr. Ryan. "More research is needed to replicate these findings and uncover underlying mechanisms for these associations."
https://www.sciencedaily.com/releases/2019/09/190925075731.htm
Is pollution linked to psychiatric disorders?
August 20, 2019
Science Daily/PLOS
Researchers are increasingly studying the effects of environmental insults on psychiatric and neurological conditions, motivated by emerging evidence from environmental events like the record-breaking smog that choked New Delhi two years ago. The results of a new study publishing August 20 in the open-access journal PLOS Biology by an international group of researchers using large data sets from the US and Denmark suggests a possible link between exposure to environmental pollution and an increase in the prevalence of psychiatric disorders.
The team found that poor air quality was associated with higher rates of bipolar disorder and major depression in both US and Danish populations. The trend appeared even stronger in Denmark, where exposure to polluted air during the first ten years of a person's life also predicted a more than two-fold increase in schizophrenia and personality disorders.
"Our study shows that living in polluted areas, especially early on in life, is predictive of mental disorders in both the United States and Denmark," said computational biologist Atif Khan, the first author of the new study. "The physical environment -- in particular air quality -- warrants more research to better understand how our environment is contributing to neurological and psychiatric disorders."
Although mental illnesses like schizophrenia develop due to a complex interplay of genetic predispositions and life experiences or exposures, genetics alone do not account entirely for variations in mental health and disease. Researchers have long suspected that genetic, neurochemical and environmental factors interact at different levels to affect the onset, severity and progression of these illnesses.
Growing evidence is beginning to provide insight into how components of air pollution can be toxic to the brain: Recent studies on rodents suggest that environmental agents like ambient small particulate matter (fine dust) travel to the brain through the nose and lungs, while animals exposed to pollution have also shown signs of cognitive impairment and depression-like behavioral symptoms. "We hypothesized that pollutants might affect our brains through neuroinflammatory pathways that have also been shown to cause depression-like signs in animal studies," said Andrey Rzhetsky, who led the new study.
To quantify air pollution exposure among individuals in the United States, the University of Chicago team relied on the US Environmental Protection Agency's measurements of 87 air quality measurements. For individuals in Denmark, they used a national pollution register that tracked a smaller number of pollutants with much higher spatial resolution.
The researchers then examined two population data sets, the first being a U.S. health insurance claims database that included 11 years of claims for 151 million individuals. The second dataset consisted of all 1.4 million individuals born in Denmark from 1979 through 2002 who were alive and residing in Denmark at their tenth birthday. Because Danes are assigned unique identification numbers that can link information from various national registries, the researchers were able to estimate exposure to air pollution at the individual level during the first ten years of their life. In the US study, exposure measurements were limited to the county level. "We strived to provide validation of association results in independent large datasets," said Rzhetsky.
The findings have not been without controversy. "This study on psychiatric disorders is counterintuitive and generated considerable resistance from reviewers," said Rzhetsky. Indeed, the divided opinions of the expert reviewers prompted PLOS Biology to commission a special companion article from Prof. John Ioannidis of Stanford University (Ioannidis is unconnected with the study, but assisted the journal with the editorial process).
"A causal association of air pollution with mental diseases is an intriguing possibility. Despite analyses involving large datasets, the available evidence has substantial shortcomings and a long series of potential biases may invalidate the observed associations," says Ioannidis in his commentary. "More analyses by multiple investigators, including contrarians, are necessary."
Rzhetsky also cautioned that the significant associations between air pollution and psychiatric disorders discovered in the study do not necessarily mean causation, and said that further research is needed to assess whether any neuroinflammatory impacts of air pollution share common pathways with other stress-induced conditions.
https://www.sciencedaily.com/releases/2019/08/190820141604.htm
Air pollution linked to childhood anxiety
Researchers investigate traffic-related air pollution and symptoms of childhood anxiety, through neuroimaging
May 21, 2019
Science Daily/University of Cincinnati Academic Health Center
A new study looks at the correlation between exposure to traffic-related air pollution (TRAP) and childhood anxiety, by looking at the altered neurochemistry in pre-adolescents.
Exposure to air pollution is a well-established global health problem associated with complications for people with asthma and respiratory disease, as well as heart conditions and an increased risk of stroke, and according to the World Health Organization, is responsible for millions of deaths annually. Emerging evidence now suggests that air pollution may also impact the metabolic and neurological development of children.
A new study from researchers at the University of Cincinnati and Cincinnati Children's Hospital Medical Center looks at the correlation between exposure to traffic-related air pollution (TRAP) and childhood anxiety, by looking at the altered neurochemistry in pre-adolescents.
"Recent evidence suggests the central nervous system is particularly vulnerable to air pollution, suggesting a role in the etiology of mental disorders, like anxiety or depression," says Kelly Brunst, PhD, assistant professor in the Department of Environmental Health at the College of Medicine, and lead author on the study.
"This is the first study to use neuroimaging to evaluate TRAP exposure, metabolite dysregulation in the brain and generalized anxiety symptoms among otherwise healthy children," says Brunst.
The study was published by the journal Environmental Research.
The researchers evaluated imaging of 145 children at an average age of 12 years, looking specifically at the levels of myo-inositol found in the brain through a specialized MRI technique, magnetic resonance spectroscopy. Myo-inositol is a naturally-occurring metabolite mainly found in specialized brain cells known as glial cells, that assists with maintaining cell volume and fluid balance in the brain, and serves as a regulator for hormones and insulin in the body. Increases in myo-inositol levels correlate with an increased population of glial cells, which often occurs in states of inflammation.
They found that, among those exposed to higher levels of recent TRAP, there were significant increases of myo-inositol in the brain, compared to those with lower TRAP exposure. They also observed increases in myo-inositol to be associated with more generalized anxiety symptoms. "In the higher, recent exposure group, we saw a 12% increase in anxiety symptoms," says Brunst.
Brunst noted however, that the observed increase in reported generalized anxiety symptoms in this cohort of typically developing children was relatively small and are not likely to result in a clinical diagnosis of an anxiety disorder. "However, I think it can speak to a bigger impact on population health ... that increased exposure to air pollution can trigger the brain's inflammatory response, as evident by the increases we saw in myo-inositol," says Brunst. "This may indicate that certain populations are at an increased risk for poorer anxiety outcomes."
https://www.sciencedaily.com/releases/2019/05/190521162421.htm